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Recent experiments on vesicles formed from block copolymers with liquid-crystalline side-chains reveal a rich variety of vesicle morphologies. The additional internal order ("structure") developed by these self-assembled block copolymer…

Soft Condensed Matter · Physics 2012-05-21 Xiangjun Xing , Homin Shin , Mark J. Bowick , Zhenwei Yao , Lin Jia , Min-Hui Li

The extraction of membrane tubes by molecular motors is known to play an important role for the transport properties of eukaryotic cells. By studying a generic class of models for the tube extraction, we discover a rich phase diagram. In…

Statistical Mechanics · Physics 2009-04-07 J. Tailleur , M. R. Evans , Y. Kafri

The detachment dynamics of a fluid membrane with an isotropic spontaneous curvature from a flat substrate are studied by using meshless membrane simulations. The membrane is detached from an open edge leading to vesicle formation. With…

Soft Condensed Matter · Physics 2019-11-11 Hiroshi Noguchi

Proteins form a very important class of polymers. In spite of major advances in the understanding of polymer science, the protein problem has remained largely unsolved. Here, we show that a polymer chain viewed as a tube not only captures…

Biological Physics · Physics 2007-05-23 J. R. Banavar , A. Flammini , D. Marenduzzo , A. Maritan , A. Trovato

Cellular membranes are a heterogeneous mix of lipids, proteins and small molecules. Special groupings of saturated lipids and cholesterol form a liquid-ordered phase, known as `lipid rafts,' serving as platforms for signaling, trafficking…

Quantitative Methods · Quantitative Biology 2015-05-13 Tristan S. Ursell , William S. Klug , Rob Phillips

Aggregation of like-charged polymers is widely observed in biological and soft matter systems. In many systems, bundles are formed when a short-range attraction of diverse physical origin like charge-bridging, hydrogen-bonding or…

Soft Condensed Matter · Physics 2016-06-22 Sandipan Dutta , P. Benetatos , Y. S. Jho

Membrane deformation inside living cells is crucial for the proper shaping of various intracellular organelles and is necessary during the fission/fusion processes that allow membrane recycling and transport (e.g. endocytosis). Proteins…

Biological Physics · Physics 2016-01-20 Urška Jelerčič , Nir S. Gov

Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for understanding tissue homeostasis and stable developmental processes. However, numerical simulations…

Tissues and Organs · Quantitative Biology 2023-03-08 Nen Saito , Shuji Ishihara

Our understanding of the mechanism by which topological defects are formed in symmetry breaking phase transitions has recently changed. We examine the non-equilibrium dynamics of defect formation for weakly-coupled global O(N) theories…

High Energy Physics - Theory · Physics 2010-11-01 A. J. Gill , R. J. Rivers

The diffusion of particles in confining walls forming a tube is discussed. Such a transport phenomenon is observed in biological cells and porous media. We consider the case in which the tube is winding with curvature and torsion, and the…

Mathematical Physics · Physics 2015-05-30 Naohisa Ogawa

The interaction between nano- or micro-sized particles and cell membranes is of crucial importance in many biological and biomedical applications such as drug and gene delivery to cells and tissues. During their cellular uptake, the…

Torques on interfaces can be described by a divergence-free tensor which is fully encoded in the geometry. This tensor consists of two terms, one originating in the couple of the stress, the other capturing an intrinsic contribution due to…

Soft Condensed Matter · Physics 2011-11-09 Martin Michael Mueller , Markus Deserno , Jemal Guven

Circulating tumor cells (CTCs) have crucial roles in the spread of tumors during metastasis. A decisive step is the extravasation of CTCs from the blood stream or lymph system, which depends on the ability of cells to attach to vessel…

The bioactivity of nanoparticles crucially depends on their ability to cross biomembranes. Recent simulations indicate the cooperative wrapping and internalization of spherical nanoparticles in tubular membrane structures. In this article,…

Soft Condensed Matter · Physics 2014-01-09 Michael Raatz , Reinhard Lipowsky , Thomas R. Weikl

We present a general theory for the equilibrium structure of cylindrical tubules and helical ribbons of chiral lipid membranes. This theory is based on a continuum elastic free energy that permits variations in the direction of molecular…

Condensed Matter · Physics 2009-10-28 J. V. Selinger , F. C. MacKintosh , J. M. Schnur

In living cells, membrane morphology is regulated by various proteins. Many membrane reshaping proteins contain a Bin/Amphiphysin/Rvs (BAR) domain, which consists of a banana-shaped rod. The BAR domain bends the biomembrane along the rod…

Soft Condensed Matter · Physics 2016-02-15 Hiroshi Noguchi

A concentration difference of particles across a membrane perforated by pores will induce a diffusive flux. If the diffusing objects are of the same length scale as the the pores, diffusion may not be simple, objects can move into the pore…

Soft Condensed Matter · Physics 2015-05-18 Robert S. Shaw , Norman H. Packard

We outline a concept of self-assembled soft matter devices based on micro-fluidics, which use surfactant bilayer membranes as their main building blocks, arrested in geometric structures provided by top-down lithography. Membranes form…

Soft Condensed Matter · Physics 2011-03-29 Shashi Thutupalli , Stephan Herminghaus , Ralf Seemann

We study composed map germs with respect to their local fibrations. Under most general conditions, inspired by the tameness condition that was introduced recently, we prove the existence of singular tube fibrations, and we determine the…

Algebraic Geometry · Mathematics 2024-01-25 Ying Chen , Cezar Joiţa , Mihai Tibăr

The essence of turbulent flow is the conveyance of energy through the formation, interaction, and destruction of eddies over a wide range of spatial scales--from the largest scales where energy is injected, down to the smallest scales where…