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Coarse-grained (CG) molecular simulations have become a standard tool to study molecular processes on time- and length-scales inaccessible to all-atom simulations. Parameterizing CG force fields to match all-atom simulations has mainly…

Computational Physics · Physics 2023-02-07 Jonas Köhler , Yaoyi Chen , Andreas Krämer , Cecilia Clementi , Frank Noé

We consider a coarse-grained model in which polymers under good-solvent conditions are represented by soft spheres whose radii, which should be identified with the polymer radii of gyrations, are allowed to fluctuate. The corresponding pair…

Soft Condensed Matter · Physics 2012-06-19 Giuseppe D'Adamo , Andrea Pelissetto , Carlo Pierleoni

We present an approach for calculating coarse-grained angle-resolved effective pair potentials for uniaxial molecules. For integrating out the intramolecular degrees of freedom we apply umbrella sampling and steered dynamics techniques in…

Soft Condensed Matter · Physics 2016-03-15 Thomas Heinemann , Karol Palczynski , Joachim Dzubiella , Sabine H. L. Klapp

Due to the wide range of timescales that are present in macromolecular systems, hierarchical multiscale strategies are necessary for their computational study. Coarse-graining (CG) allows to establish a link between different system…

Entangled polymers are deformed by a strong shear flow. The shape of the polymer, called the form factor, is measured by small angle neutron scattering. However, the real-space molecular structure is not directly available from the…

Bio-inspired composites are a great promise for mimicking the extraordinary and highly efficient properties of natural materials. Recent developments in voxel-by-voxel 3D printing have enabled extreme levels of control over the material…

The accuracy of molecular simulations is fundamentally limited by the interatomic potentials that govern atomic interactions. Traditional potential development, which relies heavily on ab initio calculations, frequently struggles to…

Disordered Systems and Neural Networks · Physics 2025-10-16 Ruoxia Chen , Kai Yang , Morten M. Smedskjaer , N. M. Anoop Krishnan , Jaime Marian , Fabian Rosner

The properties of polymer liquids on hard and soft substrates are investigated by molecular dynamics simulation of a coarse-grained bead-spring model and dynamic single-chain-in-mean-field (SCMF) simulations of a soft, coarse-grained…

Soft Condensed Matter · Physics 2015-05-18 F. Léonforte , J. Servantie , C. Pastorino , M. Müller

Machine learning (ML) offers considerable promise for the design of new molecules and materials. In real-world applications, the design problem is often domain-specific, and suffers from insufficient data, particularly labeled data, for ML…

Chemical Physics · Physics 2025-02-04 Ming Han , Ge Sun , Juan J. de Pablo

The unfolding of molecular complexes or biomolecules under the influence of external mechanical forces can routinely be simulated with atomistic resolution. To obtain a match of the characteristic time scales with those of experimental…

Soft Condensed Matter · Physics 2024-07-17 Marco Oestereich , Jürgen Gauss , Gregor Diezemann

The recent discovery of magic angle twisted bilayer graphene (MATBG), in which two sheets of monolayer graphene are precisely stacked to a specific angle, has opened up a plethora of new opportunities in the field of topology,…

Mesoscale and Nanoscale Physics · Physics 2024-06-06 Roop Kumar Mech , Jean Spièce , Kenji Watanabe , Takashi Taniguchi , Pascal Gehring

A first-principle multiscale modeling approach is presented, which is derived from the solution of the Ornstein-Zernike equation for the coarse-grained representation of polymer liquids. The approach is analytical, and for this reason is…

Soft Condensed Matter · Physics 2009-09-09 J. McCarty , I. Y. Lyubimov , M. G. Guenza

An innovative method is proposed to generate configurations of coarse grained models for polymer melts. This method, largely inspired by chemical ``radical polymerization'', is divided in three stages: (i) nucleation of radicals (reacting…

Statistical Mechanics · Physics 2007-12-24 Fabien Leonforte , Michel Perez , Olivier Lame , Jena-Louis Barrat

Simulations have acted as a cornerstone to understand MOF/polymer interface structure, however, no molecular-level simulation has yet been performed at the nanoparticle scale. In this work, a hybrid MARTINI/Force Matching (FM) force field…

Chemical Physics · Physics 2024-10-22 Cecilia M. S. Alvares , Rocio Semino

Coarse graining enables the investigation of molecular dynamics for larger systems and at longer timescales than is possible at atomic resolution. However, a coarse graining model must be formulated such that the conclusions we draw from it…

Elastic network models, simple structure-based representations of biomolecules where atoms interact via short-range harmonic potentials, provide great insight into a molecule's internal dynamics and mechanical properties at extremely low…

Soft Condensed Matter · Physics 2018-12-12 Patrick Diggins , Changjiang Liu , Markus Deserno , Raffaello Potestio

In this study, we apply, for the first time, the fully atomistic force field approach to modeling light-induced deformations of azo-polymers, thereby establishing a relationship between macroscopic parameters and the microscopic molecular…

Soft Condensed Matter · Physics 2025-11-26 Dmitry A. Ryndyk , Olga Guskova , Marina Saphiannikova

Due to the complex characteristics of bottle-brush polymers, it became a challenge to develop an efficient algorithm for studying such macromolecules under various solvent conditions or some constraints in the space by using computer…

Soft Condensed Matter · Physics 2011-07-08 Hsiao-Ping Hsu

During the carbonization process of raw polymer precursors, graphitic structures can evolve. The presence of these graphitic structures affects mechanical properties of the carbonized carbon fibers. To gain a better understanding of the…

An accurate force field is the key to the success of all molecular mechanics simulations on organic polymers and biomolecules. Accuracy beyond density functional theory is often needed to describe the intermolecular interactions, while most…

Chemical Physics · Physics 2021-08-13 Xufei Wang , Yuanda Xu , Han Zheng , Kuang Yu