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The general Helfrich shape equation determined by minimizing the curvature free energy describes the equilibrium shapes of the axisymmetric lipid bilayer vesicles in different conditions. It is a non-linear differential equation with…

Soft Condensed Matter · Physics 2009-10-31 Zhan-Ning Hu

Within the framework of the well-known curvature models, a fluid lipid bilayer membrane is regarded as a surface embedded in the three-dimensional Euclidean space whose equilibrium shapes are described in terms of its mean and Gaussian…

Mathematical Physics · Physics 2009-10-22 V. M. Vassilev , P. A. Djondjorov , I. M. Mladenov

We use theory and numerical computation to determine the shape of an axisymmetric fluid membrane with a resistance to bending and constant area. The membrane connects two rings in the classic geometry that produces a catenoidal shape in a…

Soft Condensed Matter · Physics 2021-08-12 Leroy L. Jia , Steven Pei , Robert A. Pelcovits , Thomas R. Powers

The equilibrium shapes of vesicles are governed by the general shape equation which is derived from the minimization of the Helfrich elastic free energy and can be reduced to the Willmore equation in a special case. The general shape…

Soft Condensed Matter · Physics 2017-08-28 Xiaohua Zhou

Consider a homogenous fluid membrane, or vesicle, described by the Helfrich-Canham energy, quadratic in the mean curvature. When the membrane is axially symmetric, this energy can be viewed as an `action' describing the motion of a…

Soft Condensed Matter · Physics 2009-11-11 Riccardo Capovilla , Jemal Guven , Efrain Rojas

Only some special open surfaces satisfying the shape equation of lipid membranes can be compatible with the boundary conditions. As a result of this compatibility, the first integral of the shape equation should vanish for axisymmetric…

Soft Condensed Matter · Physics 2010-02-25 Z. C. Tu

We consider a well known model for lipid-bilayer membrane vesicles exhibiting phase separation, incorporating a phase field with finite curvature elasticity. We prove the existence of a plethora of equilibria, corresponding to…

Analysis of PDEs · Mathematics 2018-12-11 Timothy J. Healey , Sanjay Dharmavaram

The shape equation of lipid membranes [Zhong-can and Helfrich(1987) PRL 59 2486] is a fourth-order partial differential equation. Under the axisymmetric condition, this equation was transformed into a second-order ordinary differential…

Mathematical Physics · Physics 2020-07-21 Y. H. Zhang , Z. McDargh , Z. C. Tu

Lipid bilayer membranes are commonly modeled as area-preserving fluid surfaces that resist bending. There appear to be two schools of thought in the literature concerning the actual area constraint. In some works the total or global area…

Biological Physics · Physics 2015-06-23 Sanjay Dharmavaram , Timothy J. Healey

We study a model for lipid-bilayer membrane vesicles exhibiting phase separation, incorporating a phase field together with membrane fluidity and bending elasticity. We prove the existence of a plethora of equilibria in the large,…

Analysis of PDEs · Mathematics 2015-09-18 Timothy J. Healey , Sanjay Dharmavaram

We present Monte Carlo simulations of an ultra coarse-grained lipid bilayer with different number of lipids on both leaflets. In the simulations, we employ a new method for measuring the elastic parameters of the membrane, including the…

Soft Condensed Matter · Physics 2025-05-20 Oded Farago

We address the geometric Cauchy problem for surfaces associated to the membrane shape equation describing equilibrium configurations of vesicles formed by lipid bilayers. This is the Euler-Lagrange equation of the Canham-Helfrich-Evans…

Differential Geometry · Mathematics 2014-11-18 Gary R. Jensen , Emilio Musso , Lorenzo Nicolodi

The issue of different parameterizations of the axisymmetric vesicle shape addressed by Hu Jian-Guo and Ou-Yang Zhong-Can [ Phys.Rev. E {\bf 47} (1993) 461 ] is reassesed, especially as it transpires through the corresponding Euler -…

Condensed Matter · Physics 2009-10-22 R. Podgornik , S. Svetina , B. Žekš

We examine the reaction of a homogeneous spherical fluid vesicle to the force exerted by a rigid circular ring located at its equator in the linear regime. We solve analytically the linearized first integral of the Euler-Lagrange equation…

Soft Condensed Matter · Physics 2026-02-02 Andrés Solís-Cuevas , Pablo Vázquez-Montejo

Correctly formulated continuum models for lipid-bilayer membranes present a significant challenge to computational mechanics. In particular, the mid-surface behavior is that of a 2-dimensional fluid, while the membrane resists bending much…

Soft Condensed Matter · Physics 2017-03-08 Siming Zhao , Timothy Healey , Qingdu Li

The disk-to-vesicle transition of a fluid membrane with no spontaneous curvature is well described by the competition between edge line and curvature energies. However, the transition of asymmetric membranes with spontaneous curvatures is…

Soft Condensed Matter · Physics 2019-09-24 Hiroshi Noguchi

A continuous transformation from a closed vesicle to an open vesicle needs that the area of open hole enlarge from zero. Since the shape equation and boundary conditions of lipid open vesicles with free edges have been obtained, we want…

Soft Condensed Matter · Physics 2019-09-04 Xiaohua Zhou

An elastic sheet lying on the surface of a liquid, if axially compressed, shows a transition from a smooth sinusoidal pattern to a well localized fold. This wrinkle-to-fold transition is a manifestation of a localized buckling. The…

Soft Condensed Matter · Physics 2013-03-06 Marco Rivetti

The tensile force along a cylindrical lipid bilayer tube is proportional to the membrane's bending modulus and inversely proportional to the tube radius. We show that this relation, which is experimentally exploited to measure bending…

Soft Condensed Matter · Physics 2007-05-23 Vagelis A. Harmandaris , Markus Deserno

We present a meshless numerical method for simulating the dynamics of axisymmetric vesicles in a viscous medium. Key innovations include: (1) adaptive reparameterization based on local length scales, reducing the number of required…

Computational Physics · Physics 2026-04-17 M. A. Shishkin
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