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Many recently introduced enhanced sampling techniques are based on biasing coarse descriptors (collective variables) of a molecular system on the fly. Sometimes the calculation of such collective variables is expensive and becomes a…

Computational Physics · Physics 2015-09-01 Marco Jacopo Ferrarotti , Sandro Bottaro , Andrea Pérez-Villa , Giovanni Bussi

Computer simulations have become an important tool across the biomedical sciences and beyond. For many important problems several different models or hypotheses exist and choosing which one best describes reality or observed data is not…

Quantitative Methods · Quantitative Biology 2010-01-20 Tina Toni , Michael P. H. Stumpf

Molecular dynamics simulations have the potential to provide atomic-level detail and insight to important questions in chemical physics that cannot be observed in typical experiments. However, simply generating a long trajectory is…

Chemical Physics · Physics 2015-06-22 Christian R. Schwantes , Robert T. McGibbon , Vijay S. Pande

Single-molecule tracking is a powerful way to look at the dynamic organization of plasma membranes. However, there are some limitations to its use. For example, it was recently observed, using numerical simulation, that time-averaging…

Quantitative Methods · Quantitative Biology 2009-11-13 Nicolas Destainville , Laurence Salome

The modern study of the dynamics of stellar systems requires the use of high-performance computers. Indeed, an accurate modelization of the structure and evolution of self-gravitating systems like planetary systems, open clusters, globular…

Astrophysics · Physics 2015-06-10 R. Capuzzo-Dolcetta , P. Di Matteo , P. Miocchi

We show that the exact exchange-correlation potential of time-dependent density-functional theory displays dynamical step structures that have a spatially non-local and time non-local dependence on the density. Using one-dimensional…

Chemical Physics · Physics 2015-06-12 Peter Elliott , Johanna I. Fuks , Angel Rubio , Neepa T. Maitra

Contemporary statistical publications rely on simulation to evaluate performance of new methods and compare them with established methods. In the context of meta-analysis of log-odds-ratios, we investigate how the ways in which simulations…

Methodology · Statistics 2020-07-06 Elena Kulinskaya , David C. Hoaglin , Ilyas Bakbergenuly

Discrete simulation methods are efficient tools to investigate the complex behaviors of complex fluids made of either dry granular materials or dilute suspensions. By contrast, materials made of soft and/or concentrated units (emulsions,…

Fluid Dynamics · Physics 2008-12-18 Pierre Rognon , Cyprien Gay

The dynamics of biological systems, from proteins to cells to organisms, is complex and stochastic. To decipher their physical laws, we need to bridge between experimental observations and theoretical modeling. Thanks to progress in…

Soft Condensed Matter · Physics 2024-06-05 Pierre Ronceray

The simulation of quantum systems has been a key aim of quantum technologies for decades, and the generalisation to open systems is necessary to include physically realistic systems. We introduce an approach for quantum simulations of open…

Quantum Physics · Physics 2015-09-14 Benjamin Dive , Florian Mintert , Daniel Burgarth

Inspired by the need for effective stochastic models to describe the complex behavior of biological motor proteins that move on linear tracks exact results are derived for the velocity and dispersion of simple linear sequential models (or…

Statistical Mechanics · Physics 2009-10-31 Anatoly B. Kolomeisky , Michael E. Fisher

Dual-unitary circuits have emerged as a minimal model for chaotic quantum many-body dynamics in which the dynamics of correlations and entanglement remains tractable. Simultaneously, there has been intense interest in the effect of…

Quantum Physics · Physics 2023-02-09 Pieter W. Claeys , Marius Henry , Jamie Vicary , Austen Lamacraft

Coarse-graining of fully atomistic molecular dynamics simulations is a long-standing goal in order to allow the description of processes occurring on biologically relevant timescales. For example, the prediction of pathways, rates and…

Biological Physics · Physics 2020-06-12 Steffen Wolf , Benjamin Lickert , Simon Bray , Gerhard Stock

With the advent of digital and analog quantum simulation experiments, it is now possible to experimentally simulate dynamics of quantum many-body lattice systems and make site-resolved measurements. These experiments make it pertinent to…

Quantum Physics · Physics 2024-03-22 Archak Purkayastha , Alberto Imparato

We propose a computational method to quantitatively evaluate the systematic uncertainties that arise from undetectable sources in biological measurements using live-cell imaging techniques. We then demonstrate this method in measuring…

Quantitative Methods · Quantitative Biology 2019-07-09 Masaki Watabe , Satya N. V. Arjunan , Wei Xiang Chew , Kazunari Kaizu , Koichi Takahashi

System identification aims to build models of dynamical systems from data. Traditionally, choosing the model requires the designer to balance between two goals of conflicting nature; the model must be rich enough to capture the system…

Machine Learning · Computer Science 2021-08-09 Antônio H. Ribeiro , Johannes N. Hendriks , Adrian G. Wills , Thomas B. Schön

The exact study of small systems can guide us toward measures for extracting information about many-body physics as we move to more complex systems capable of quantum information processing or quantum analog simulation. We use exact…

Mesoscale and Nanoscale Physics · Physics 2021-06-10 Emily Townsend , Tomáš Neuman , Alex Debrecht , Javier Aizpurua , Garnett W. Bryant

Molecular dynamics computer simulations are used to investigate thedynamics of a binary mixture of charged (Yukawa) particles with a size-ratio of 1:5. We find that the system undergoes a phase transition where the large particles…

Disordered Systems and Neural Networks · Physics 2015-06-25 Norio Kikuchi , Juergen Horbach

Studying systems where many individual bodies in motion interact with one another is a complex and interesting area. Simple mechanisms that may be determined for biological, chemical, or physical reasons can lead to astonishingly complex…

Quantitative Methods · Quantitative Biology 2023-01-03 Cameron McNamee , Renee Reijo Pera

Stochastic quantization offers the opportunity to simulate field theories with a complex action. In some theories unstable trajectories are prevalent when a constant stepsize is employed. We construct algorithms for generating an adaptive…

High Energy Physics - Lattice · Physics 2014-11-20 Gert Aarts , Frank A. James , Erhard Seiler , Ion-Olimpiu Stamatescu