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A new type of microfluidic system for biological cell manipulation, a CMOS/microfluidic hybrid, is demonstrated. The hybrid system starts with a custom-designed CMOS (complementary metal-oxide semiconductor) chip fabricated in a…

Quantitative Methods · Quantitative Biology 2007-05-23 Hakho Lee , Yong Liu , Donhee Ham , Robert M. Westervelt

Many modern workloads such as neural network inference and graph processing are fundamentally memory-bound. For such workloads, data movement between memory and CPU cores imposes a significant overhead in terms of both latency and energy. A…

Hardware Architecture · Computer Science 2023-04-04 Juan Gómez-Luna , Izzat El Hajj , Ivan Fernandez , Christina Giannoula , Geraldo F. Oliveira , Onur Mutlu

Memory latency, bandwidth, capacity, and energy increasingly limit performance. In this paper, we reconsider proposed system architectures that consist of huge (many-terabyte to petabyte scale) memories shared among large numbers of CPUs.…

Hardware Architecture · Computer Science 2025-09-24 Samuel Dayo , Shuhan Liu , Peijing Li , Philip Levis , Subhasish Mitra , Thierry Tambe , David Tennenhouse , H. -S. Philip Wong

Modern computing systems suffer from the dichotomy between computation on one side, which is performed only in the processor (and accelerators), and data storage/movement on the other, which all other parts of the system are dedicated to.…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-05-14 Onur Mutlu , Saugata Ghose , Juan Gómez-Luna , Rachata Ausavarungnirun

Processing-in-Memory (PIM) architectures offer promising solutions for efficiently handling AI applications in energy-constrained edge environments. While traditional PIM designs enhance performance and energy efficiency by reducing data…

Hardware Architecture · Computer Science 2025-12-09 Sangmin Jeon , Kangju Lee , Kyeongwon Lee , Woojoo Lee

In-memory computing (IMC) with single instruction multiple data (SIMD) setup enables memory to perform operations on the stored data in parallel to achieve high throughput and energy saving. To instruct a SIMD IMC hardware to compute a…

Emerging Technologies · Computer Science 2024-12-04 Xingyue Qian , Chenyang Lv , Zhezhi He , Weikang Qian

Stacked intelligent metasurfaces (SIMs), which integrate multiple programmable metasurface layers, have recently emerged as a promising technology for advanced wave-domain signal processing. SIMs benefit from flexible spatial…

When a single core is scaled up to m cores occupying the same chip area and executing the same (parallelizable) task, achievable speedup is square-root m, power is reduced by square-root m and energy is reduced by m. Thus, many-core…

Hardware Architecture · Computer Science 2025-02-04 Ran Ginosar

Fast combinational multipliers with large bit widths can occupy significant silicon area, which also drives up power consumption. Area can be reduced through resource sharing (i.e., folding) at the expense of lower throughput, which is…

Hardware Architecture · Computer Science 2025-09-03 Ahmad Houraniah , H. Fatih Ugurdag , C. Emre Dedeagac

Today's systems are overwhelmingly designed to move data to computation. This design choice goes directly against at least three key trends in systems that cause performance, scalability and energy bottlenecks: (1) data access from memory…

Hardware Architecture · Computer Science 2019-03-12 Onur Mutlu , Saugata Ghose , Juan Gómez-Luna , Rachata Ausavarungnirun

Memory-centric computing aims to enable computation capability in and near all places where data is generated and stored. As such, it can greatly reduce the large negative performance and energy impact of data access and data movement, by…

Hardware Architecture · Computer Science 2023-09-15 Onur Mutlu

Processing-in-Memory (PIM) has emerged as a promising computing paradigm to address the memory wall and the fundamental bottleneck of the von Neumann architecture by reducing costly data movement between memory and processing units. As with…

Hardware Architecture · Computer Science 2025-12-02 Mahdi Aghaei , Saba Ebrahimi , Mohammad Saleh Arafati , Elham Cheshmikhani , Dara Rahmati , Saeid Gorgin , Jungrae Kim

Two essential problems in Computer Algebra, namely polynomial factorization and polynomial greatest common divisor computation, can be efficiently solved thanks to multiple polynomial evaluations in two variables using modular arithmetic.…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-04-27 Pierre Fortin , Ambroise Fleury , François Lemaire , Michael Monagan

With high computation power and memory bandwidth, graphics processing units (GPUs) lend themselves to accelerate data-intensive analytics, especially when such applications fit the single instruction multiple data (SIMD) model. However,…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-12-12 Hang Liu , H. Howie Huang

Computational intensity and sequential nature of estimation techniques for Bayesian methods in statistics and machine learning, combined with their increasing applications for big data analytics, necessitate both the identification of…

Computation · Statistics 2015-03-02 Alireza S. Mahani , Mansour T. A. Sharabiani

Hardware/Software (HW/SW) co-designed processors provide a promising solution to the power and complexity problems of the modern microprocessors by keeping their hardware simple. Moreover, they employ several runtime optimizations to…

Hardware Architecture · Computer Science 2021-03-01 Rakesh Kumar , Alejandro Martinez , Antonio Gonzalez

Many modern and emerging applications must process increasingly large volumes of data. Unfortunately, prevalent computing paradigms are not designed to efficiently handle such large-scale data: the energy and performance costs to move this…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-07-31 Saugata Ghose , Amirali Boroumand , Jeremie S. Kim , Juan Gómez-Luna , Onur Mutlu

Single instruction, multiple data (SIMD) is a popular design style of in-memory computing (IMC) architectures, which enables memory arrays to perform logic operations to achieve low energy consumption and high parallelism. To implement a…

Emerging Technologies · Computer Science 2024-12-04 Xingyue Qian , Chen Nie , Zhezhi He , Weikang Qian

Manycore SoC architectures based on on-chip shared memory are preferred for flexible and programmable solutions in many application domains. However, the development of many ported memory is becoming increasingly challenging as we approach…

Hardware Architecture · Computer Science 2020-10-20 Hao Luan , Alan Gatherer

Current AI training infrastructure is dominated by single instruction multiple data (SIMD) and systolic array architectures, such as Graphics Processing Units (GPUs) and Tensor Processing Units (TPUs), that excel at accelerating parallel…

Neural and Evolutionary Computing · Computer Science 2023-11-09 Jan Finkbeiner , Thomas Gmeinder , Mark Pupilli , Alexander Titterton , Emre Neftci