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The capacity of proteins to interact specifically with one another underlies our conceptual understanding of how living systems function. Systems-level study of specificity in protein-protein interactions is complicated by the fact that the…

Biomolecules · Quantitative Biology 2009-11-13 Eric Deeds , orr Ashenberg , Jaline Gerardine , Eugene Shakhnovich

Biological and social systems are structured at multiple scales, and the incentives of individuals who interact in a group may diverge from the collective incentive of the group as a whole. Mechanisms to resolve this tension are responsible…

Populations and Evolution · Quantitative Biology 2023-05-31 Daniel B. Cooney , Simon A. Levin , Yoichiro Mori , Joshua B. Plotkin

Empirical evidence suggesting that living systems might operate in the vicinity of critical points, at the borderline between order and disorder, has proliferated in recent years, with examples ranging from spontaneous brain activity to…

Statistical Mechanics · Physics 2014-07-25 Jorge Hidalgo , Jacopo Grilli , Samir Suweis , Miguel A. Munoz , Jayanth R. Banavar , Amos Maritan

Universal and rigorously derived concept of dynamic complexit (physics/9806002) shows that any system of interacting components, including society and civilisation, exists only as a process of highly inhomogeneous, qualitative development…

General Physics · Physics 2007-05-23 Andrei P. Kirilyuk

We propose a method to procedurally generate a familiar yet complex human artifact: the city. We are not trying to reproduce existing cities, but to generate artificial cities that are convincing and plausible by capturing developmental…

Graphics · Computer Science 2025-07-28 Thomas Lechner , Ben Watson , Uri Wilensky , Martin Felsen

The simplest model of a smart spatial redistribution of individuals is proposed. A single-species population is considered, to be composed of two discrete subpopulations inhabiting two stations; migration is a transfer between them. The…

Populations and Evolution · Quantitative Biology 2016-09-08 Michael Sadovsky

A major issue in biology is the understanding of the interactions between proteins. These interactions can be described by a network, where the proteins are modeled by nodes and the interactions by edges. The origin of these protein…

Biological Physics · Physics 2011-08-01 Christian M. Schneider , Lucilla de Arcangelis , Hans J. Herrmann

We consider the basic features of complex dynamic and control systems, including systems having hierarchical structure. Special attention is paid to the problems of design and synthesis of complex systems and control models, and to the…

Computational Engineering, Finance, and Science · Computer Science 2008-12-25 Armen Bagdasaryan

In a combinatorial communication system, some signals consist of the combinations of other signals. Such systems are more efficient than equivalent, non-combinatorial systems, yet despite this they are rare in nature. Why? Previous…

Populations and Evolution · Quantitative Biology 2015-05-26 Thomas C. Scott-Phillips , Richard A. Blythe

Most of the complex social, technological and biological networks have a significant community structure. Therefore the community structure of complex networks has to be considered as a universal property, together with the much explored…

Physics and Society · Physics 2014-12-02 Ginestra Bianconi , Richard K. Darst , Jacopo Iacovacci , Santo Fortunato

The network concept is increasingly used for the description of complex systems. Here we summarize key aspects of the evolvability and robustness of the hierarchical network-set of macromolecules, cells, organisms, and ecosystems. Listing…

Molecular Networks · Quantitative Biology 2010-10-05 Huba J. M. Kiss , Agoston Mihalik , Tibor Nanasi , Balint Ory , Zoltan Spiro , Csaba Soti , Peter Csermely

We study analytically and numerically a model metabolic cycle composed of an arbitrary number of species of catalytically active particles. Each species converts a substrate into a product, the latter being used as the substrate by the next…

Soft Condensed Matter · Physics 2023-09-29 Vincent Ouazan-Reboul , Jaime Agudo-Canalejo , Ramin Golestanian

Bacteria possess diverse mechanisms to regulate their motility in response to environmental and physiological signals, enabling them to navigate complex habitats and adapt their behavior. Among these mechanisms, interspecies recognition…

Populations and Evolution · Quantitative Biology 2025-12-01 Mattia Mattei , David Soriano Paños , Mahantesh Halappanavar , Alex Arenas

The past two decades have seen significant successes in our understanding of complex networked systems, from the mapping of real-world social, biological and technological networks to the establishment of generative models recovering their…

This paper presents the thesis that all learning agents of finite information size are limited by their informational structure in what goals they can efficiently learn to achieve in a complex environment. Evolutionary change is critical…

Artificial Intelligence · Computer Science 2013-04-03 Alok Raj

Mathematical models play an increasingly important role in the interpretation of biological experiments. Studies often present a model that generates the observations, connecting hypothesized process to an observed pattern. Such generative…

Populations and Evolution · Quantitative Biology 2014-06-18 Steven A. Frank

How multicellular life forms evolved out from unicellular ones constitutes a major problem in our understanding of the evolution of our biosphere. A recent set of experiments involving yeast cell populations has shown that selection for…

Populations and Evolution · Quantitative Biology 2015-11-10 Salva Duran-Nebreda , Ricard V. Solé

Composition is a powerful principle for systems biology, focused on the interfaces, interconnections, and orchestration of distributed processes to enable integrative multiscale simulations. Whereas traditional models focus on the structure…

Other Quantitative Biology · Quantitative Biology 2024-11-25 Eran Agmon

The spontaneous organization of collective activities in animal groups and societies has attracted a considerable amount of attention over the last decade. This kind of coordination often permits group-living species to achieve collective…

Physics and Society · Physics 2010-05-20 Mehdi Moussaid , Simon Garnier , Guy Theraulaz , Dirk Helbing

Recently it has been demonstrated that causal entropic forces can lead to the emergence of complex phenomena associated with human cognitive niche such as tool use and social cooperation. Here I show that even more fundamental traits…

Information Theory · Computer Science 2016-04-20 Fouad Khan