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A tumor can be thought of as an ecosystem, which critically means that we cannot just consider it as a collection of mutated cells but more as a complex system of many interacting cellular and microenvironmental elements. At its simplest, a…

Populations and Evolution · Quantitative Biology 2013-05-03 Jill Gallaher , Alexander R. A. Anderson

Proteins are the essential drivers of biological processes. At the molecular level, they are chains of amino acids that can be viewed through a linguistic lens where the twenty standard residues serve as an alphabet combining to form a…

Computation and Language · Computer Science 2025-12-15 Burak Suyunu , Özdeniz Dolu , Ibukunoluwa Abigail Olaosebikan , Hacer Karatas Bristow , Arzucan Özgür

Genotype-to-phenotype mappings translate genotypic variations such as mutations into phenotypic changes. Neutrality is the observation that some mutations do not lead to phenotypic changes. Studying the search trajectories in genotypic and…

Populations and Evolution · Quantitative Biology 2023-06-26 Ting Hu , Gabriela Ochoa , Wolfgang Banzhaf

We study the biological evolution of low-latency natural neural networks for short-term survival, and its parallels in the development of low latency high-performance Central Processing Unit in computer design and architecture. The…

Other Computer Science · Computer Science 2024-07-15 Arifa Khan , Saravanan P , Venkatesan S. K.

Much information is stored in amino acid composition of protein and base composition of DNA. We simulated the evolution of amino acid frequencies and genomic GC content by a linguistic model. It is showed that the evolution of genetic code…

Genomics · Quantitative Biology 2007-05-23 Dirson Jian Li

In the near future, all the human genes will be identified. But understanding the functions coded in the genes is a much harder problem. For example, by using block entropy, one has that the DNA code is closer to a random code then written…

Numerical Analysis · Mathematics 2007-07-13 Torbjörn Lundh

A theoretical and experimental analysis is made of the effects of self-adaptation in a simple evolving system. Specifically, we consider the effects of coding the mutation and crossover probabilities of a genetic algorithm evolving in…

adap-org · Physics 2008-02-03 C. Stephens , I. Garcia , J. Mora , H. Waelbroeck

Complex systems, such as life and languages, are governed by principles of evolution. The analogy and comparison between biology and linguistics\cite{alphafold2, RoseTTAFold, lang_virus, cell language, faculty1, language of gene, Protein…

Populations and Evolution · Quantitative Biology 2026-03-18 Li-Min Wang , Hsing-Yi Lai , Sun-Ting Tsai , Chen Siang Ng , Kevin Sheng-Kai Ma , Shan-Jyun Wu , Meng-Xue Tsai , Yi-Ching Su , Daw-Wei Wang , Tzay-Ming Hong

A genetic algorithm is suitable for exploring large search spaces as it finds an approximate solution. Because of this advantage, genetic algorithm is effective in exploring vast and unknown space such as molecular search space. Though the…

Neural and Evolutionary Computing · Computer Science 2021-12-24 Yurim Lee , Gydam Choi , Minsung Yoon , Cheongwon Kim

Genetic Algorithm (GA) is a popular meta-heuristic evolutionary algorithm that uses stochastic operators to find optimal solution and has proved its effectiveness in solving many complex optimization problems (such as classification,…

Neural and Evolutionary Computing · Computer Science 2023-05-02 Fahad Maqbool , Muhammad Saad Razzaq , Hajira Jabeen

The application of Genetic Programming to the discovery of empirical laws is often impaired by the huge size of the search space, and consequently by the computer resources needed. In many cases, the extreme demand for memory and CPU is due…

Artificial Intelligence · Computer Science 2016-08-16 Alain Ratle , Michèle Sebag

Large Language Models (LLMs) excel at generating synthetic data, but ensuring its quality and diversity remains challenging. We propose Genetic Prompt, a novel framework that combines genetic algorithms with LLMs to augment synthetic data…

Computation and Language · Computer Science 2025-09-03 Guangzeng Han , Weisi Liu , Xiaolei Huang

Progress in the field of machine learning has been fueled by the introduction of benchmark datasets pushing the limits of existing algorithms. Enabling the design of datasets to test specific properties and failure modes of learning…

A system-level genetic code is a hypothetical genetic code that exclusively or preferentially codes systems of interacting coadapted parts. System-level genetic codes differ from part-level genetic codes in which each discrete part is coded…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 John F. McGowan

Epigenetics encompasses mechanisms that can alter the expression of genes without changing the underlying genetic sequence. The epigenetic regulation of gene expression is initiated and sustained by several mechanisms such as DNA…

Genomics · Quantitative Biology 2025-04-08 Muhammad Tahir , Mahboobeh Norouzi , Shehroz S. Khan , James R. Davie , Soichiro Yamanaka , Ahmed Ashraf

Evolution consists of distinct stages: cosmological, biological, linguistic. Since biology verges on natural sciences and linguistics, we expect that it shares structures and features from both forms of knowledge. Indeed, in DNA we…

Other Quantitative Biology · Quantitative Biology 2019-10-01 Argyris Nicolaidis , Fotis Psomopoulos

Understanding the evolution of complexity is an important topic in a wide variety of academic fields. Implications of better understanding complexity include increased knowledge of major evolutionary transitions and the properties of living…

Neural and Evolutionary Computing · Computer Science 2022-09-28 Alden H. Wright , Cheyenne L. Laue

Large Language Models (LLMs) have demonstrated remarkable capabilities across various tasks, with their performance heavily dependent on the quality of input prompts. While prompt engineering has proven effective, it typically relies on…

Neural and Evolutionary Computing · Computer Science 2025-04-17 Xavier Sécheresse , Jacques-Yves Guilbert--Ly , Antoine Villedieu de Torcy

The integration of advanced technologies, such as Artificial Intelligence (AI), into manufacturing processes is attracting significant attention, paving the way for the development of intelligent systems that enhance efficiency and…

Neural and Evolutionary Computing · Computer Science 2025-12-09 Mohammadhossein Ghahramani , Yan Qiao , NaiQi Wu , Mengchu Zhou

Large Language Models (LLMs) have demonstrated great promise in generating code, especially when used inside an evolutionary computation framework to iteratively optimize the generated algorithms. However, in some cases they fail to…

Neural and Evolutionary Computing · Computer Science 2025-03-24 Niki van Stein , Anna V. Kononova , Lars Kotthoff , Thomas Bäck