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Histopathological images are widely used for the analysis of diseased (tumor) tissues and patient treatment selection. While the majority of microscopy image processing was previously done manually by pathologists, recent advances in…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Andrey Ignatov , Josephine Yates , Valentina Boeva

Given multi-type point maps from different place-types (e.g., tumor regions), our objective is to develop a classifier trained on the source place-type to accurately distinguish between two classes of the target place-type based on their…

Machine Learning · Computer Science 2025-04-25 Majid Farhadloo , Arun Sharma , Alexey Leontovich , Svetomir N. Markovic , Shashi Shekhar

Discovering genes with similar functions across diverse biomedical contexts poses a significant challenge in gene representation learning due to data heterogeneity. In this study, we resolve this problem by introducing a novel model called…

Machine Learning · Computer Science 2023-10-05 Tianyu Liu , Yuge Wang , Rex Ying , Hongyu Zhao

Recently, interest in MR-only treatment planning using synthetic CTs (synCTs) has grown rapidly in radiation therapy. However, developing class solutions for medical images that contain atypical anatomy remains a major limitation. In this…

Image and Video Processing · Electrical Eng. & Systems 2021-04-16 Hajar Emami , Ming Dong , Carri K. Glide-Hurst

Multimodal Large Language Models (MLLMs) have demonstrated remarkable potential in medical image analysis. However, their application in gastrointestinal endoscopy is currently hindered by two critical limitations: the misalignment between…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Huan Zheng , Yucheng Zhou , Tianyi Yan , Dubing Chen , Hongbo Lu , Wenlong Liao , Tao He , Pai Peng , Jianbing Shen

Effective modeling of electronic health records presents many challenges as they contain large amounts of irregularity most of which are due to the varying procedures and diagnosis a patient may have. Despite the recent progress in machine…

Machine Learning · Computer Science 2019-10-07 Sajad Darabi , Mohammad Kachuee , Majid Sarrafzadeh

Computer-aided diagnosis (CAD) based on histopathological imaging has progressed rapidly in recent years with the rise of machine learning based methodologies. Traditional approaches consist of training a classification model using features…

Computer Vision and Pattern Recognition · Computer Science 2019-03-29 Junaid Malik , Serkan Kiranyaz , Suchitra Kunhoth , Turker Ince , Somaya Al-Maadeed , Ridha Hamila , Moncef Gabbouj

Recently, deep neural networks have greatly advanced histopathology image segmentation but usually require abundant annotated data. However, due to the gigapixel scale of whole slide images and pathologists' heavy daily workload, obtaining…

Computer Vision and Pattern Recognition · Computer Science 2023-03-13 Wentao Pan , Jiangpeng Yan , Hanbo Chen , Jiawei Yang , Zhe Xu , Xiu Li , Jianhua Yao

We introduce GENomic Encoding REpresentation with Language Model (GENEREL), a framework designed to bridge genetic and biomedical knowledge bases. What sets GENEREL apart is its ability to fine-tune language models to infuse biological…

Machine Learning · Computer Science 2024-10-15 Hongyi Yuan , Suqi Liu , Kelly Cho , Katherine Liao , Alexandre Pereira , Tianxi Cai

Multimodal (MM) learning is emerging as a promising paradigm in biomedical artificial intelligence (AI) applications, integrating complementary modality, which highlight different aspects of patient health. The scarcity of large…

Artificial Intelligence · Computer Science 2025-12-01 Niccolo Marini , Zhaohui Liang , Sivaramakrishnan Rajaraman , Zhiyun Xue , Sameer Antani

To train a robust deep learning model, one usually needs a balanced set of categories in the training data. The data acquired in a medical domain, however, frequently contains an abundance of healthy patients, versus a small variety of…

Image and Video Processing · Electrical Eng. & Systems 2020-03-09 Jevgenij Gamper , Brandon Chan , Yee Wah Tsang , David Snead , Nasir Rajpoot

General-purpose AI models, particularly those designed for text and vision, demonstrate impressive versatility across a wide range of deep-learning tasks. However, they often underperform in specialised domains like medical imaging, where…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Maxime Di Folco , Emily Chan , Marta Hasny , Cosmin I. Bercea , Julia A. Schnabel

Multimodal pathological image understanding has garnered widespread interest due to its potential to improve diagnostic accuracy and enable personalized treatment through integrated visual and textual data. However, existing methods exhibit…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Zhe Xu , Cheng Jin , Yihui Wang , Ziyi Liu , Hao Chen

Melanoma, one of most dangerous types of skin cancer, re-sults in a very high mortality rate. Early detection and resection are two key points for a successful cure. Recent research has used artificial intelligence to classify melanoma and…

Computer Vision and Pattern Recognition · Computer Science 2020-08-31 Cong Tri Pham , Mai Chi Luong , Dung Van Hoang , Antoine Doucet

Computational pathology relies on effective representation learning to support cancer research and precision medicine. Although self-supervised learning has driven major progress at the patch and whole-slide image levels, representation…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Loïc Chadoutaud , Alice Blondel , Hana Feki , Jacqueline Fontugne , Emmanuel Barillot , Thomas Walter

Dermatological conditions affect 1.9 billion people globally, yet accurate diagnosis remains challenging due to limited specialist availability and complex clinical presentations. Family history significantly influences skin disease…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Satya Narayana Panda , Vaishnavi Kukkala , Spandana Iyer

Automating medical report generation from histopathology images is a critical challenge requiring effective visual representations and domain-specific knowledge. Inspired by the common practices of human experts, we propose an in-context…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Shih-Wen Liu , Hsuan-Yu Fan , Wei-Ta Chu , Fu-En Yang , Yu-Chiang Frank Wang

Histopathological analysis is the present gold standard for precancerous lesion diagnosis. The goal of automated histopathological classification from digital images requires supervised training, which requires a large number of expert…

Image and Video Processing · Electrical Eng. & Systems 2021-11-15 Yuan Xue , Jiarong Ye , Qianying Zhou , Rodney Long , Sameer Antani , Zhiyun Xue , Carl Cornwell , Richard Zaino , Keith Cheng , Xiaolei Huang

Autoregressive modeling has driven major advances in multimodal AI, yet its application to medical imaging remains constrained by the absence of a unified image tokenizer that simultaneously preserves fine-grained anatomical structures and…

Image and Video Processing · Electrical Eng. & Systems 2026-04-02 Chenglong Ma , Yuanfeng Ji , Jin Ye , Zilong Li , Chenhui Wang , Junzhi Ning , Wei Li , Lihao Liu , Qiushan Guo , Tianbin Li , Junjun He , Hongming Shan

Automating white blood cell classification for diagnosis of leukaemia is a promising alternative to time-consuming and resource-intensive examination of cells by expert pathologists. However, designing robust algorithms for classification…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Siddharth Srivastava , Adam Smith , Scott Brooks , Jack Bacon , Till Bretschneider