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Multi-agent systems must decide which agent is the most appropriate for a given task. We propose a novel architecture for recommending which LLM agent out of many should perform a task given a natural language prompt by extending the…

Machine Learning · Computer Science 2025-01-24 Joshua Park , Yongfeng Zhang

Large language models (LLMs) deployed as agents introduce significant safety risks in clinical settings due to their potential for error and single points of failure. We introduce Tiered Agentic Oversight (TAO), a hierarchical multi-agent…

The rapid deployment of LLM-based autonomous agents has introduced safety risks that extend far beyond traditional LLM concerns, prompting a proliferation of safety benchmarks since late 2023. However, these benchmarks have developed…

Computers and Society · Computer Science 2026-05-19 Miles Q. Li , Benjamin C. M. Fung , Boyang Li , Heba Ismail , Farkhund Iqbal

Clinical diagnosis requires sequential evidence acquisition under uncertainty. However, most Large Language Model (LLM) based diagnostic systems assume fully observed patient information and therefore do not explicitly model how clinical…

Artificial Intelligence · Computer Science 2026-04-08 Xuyang Shen , Haoran Liu , Dongjin Song , Martin Renqiang Min

LLMs have achieved significant performance progress in various NLP applications. However, LLMs still struggle to meet the strict requirements for accuracy and reliability in the medical field and face many challenges in clinical…

Computation and Language · Computer Science 2024-10-11 Weixiang Yan , Haitian Liu , Tengxiao Wu , Qian Chen , Wen Wang , Haoyuan Chai , Jiayi Wang , Weishan Zhao , Yixin Zhang , Renjun Zhang , Li Zhu , Xuandong Zhao

Medical Large Vision-Language Models (Med-LVLMs) have shown strong potential in multimodal diagnostic tasks. However, existing single-agent models struggle to generalize across diverse medical specialties, limiting their performance. Recent…

Machine Learning · Computer Science 2026-01-27 Peng Xia , Jinglu Wang , Yibo Peng , Kaide Zeng , Zihan Dong , Xian Wu , Xiangru Tang , Hongtu Zhu , Yun Li , Linjun Zhang , Shujie Liu , Yan Lu , Huaxiu Yao

Suicide remains a pressing global public health concern. While social media platforms offer opportunities for early risk detection through online conversation trees, existing approaches face two major limitations: (1) They rely on…

Computation and Language · Computer Science 2026-03-02 Jun Li , Xiangmeng Wang , Haoyang Li , Yifei Yan , Shijie Zhang , Hong Va Leong , Ling Feng , Nancy Xiaonan Yu , Qing Li

The increasing deployment of intelligent agents in digital ecosystems, such as social media platforms, has raised significant concerns about traceability and accountability, particularly in cybersecurity and digital content protection.…

Artificial Intelligence · Computer Science 2025-08-08 Kaibo Huang , Zipei Zhang , Zhongliang Yang , Linna Zhou

Medical decision-making often involves integrating knowledge from multiple clinical specialties, typically achieved through multidisciplinary teams. Inspired by this collaborative process, recent work has leveraged large language models…

Artificial Intelligence · Computer Science 2025-09-19 Xiao Wu , Ting-Zhu Huang , Liang-Jian Deng , Yanyuan Qiao , Imran Razzak , Yutong Xie

Recent agent-based recommendation frameworks aim to simulate user behaviors by incorporating memory mechanisms and prompting strategies, but they struggle with hallucinating non-existent items and full-catalog ranking. Besides, a largely…

Information Retrieval · Computer Science 2026-02-25 Mingdai Yang , Nurendra Choudhary , Jiangshu Du , Edward W. Huang , Philip S. Yu , Karthik Subbian , Danai Koutra

Multi-agent large language model (LLM) systems have emerged as a promising approach for clinical diagnosis, leveraging collaboration among agents to refine medical reasoning. However, most existing frameworks rely on single-vendor teams…

Computation and Language · Computer Science 2026-03-17 Grace Chang Yuan , Xiaoman Zhang , Sung Eun Kim , Pranav Rajpurkar

Large language models (LLMs) integrated with autonomous agents hold significant potential for advancing scientific discovery through automated reasoning and task execution. However, applying LLM agents to drug discovery is still constrained…

Artificial Intelligence · Computer Science 2025-07-29 Kun Li , Zhennan Wu , Shoupeng Wang , Jia Wu , Shirui Pan , Wenbin Hu

Therapeutic decision-making in clinical medicine constitutes a high-stakes domain in which AI guidance interacts with complex interactions among patient characteristics, disease processes, and pharmacological agents. Tasks such as drug…

Artificial Intelligence · Computer Science 2025-12-15 Tim Cofala , Christian Kalfar , Jingge Xiao , Johanna Schrader , Michelle Tang , Wolfgang Nejdl

Medication recommendation systems have gained significant attention in healthcare as a means of providing tailored and effective drug combinations based on patients' clinical information. However, existing approaches often suffer from…

Machine Learning · Computer Science 2024-08-13 Zihao Zhao , Yi Jing , Fuli Feng , Jiancan Wu , Chongming Gao , Xiangnan He

Safe navigation is essential for autonomous systems operating in hazardous environments. Traditional planning methods excel at long-horizon tasks but rely on a predefined graph with fixed distance metrics. In contrast, safe Reinforcement…

Robotics · Computer Science 2025-09-12 Meng Feng , Viraj Parimi , Brian Williams

Multi-agent systems built on large language models (LLMs) are difficult to reason about. Coordination errors such as deadlocks or type-mismatched messages are often hard to detect through testing. We introduce a domain-specific language for…

Programming Languages · Computer Science 2026-04-30 Benedikt Bollig , Matthias Függer , Thomas Nowak

Sequential recommender systems stand out for their ability to capture users' dynamic interests and the patterns of item-to-item transitions. However, the inherent openness of sequential recommender systems renders them vulnerable to…

Information Retrieval · Computer Science 2025-03-03 Kaike Zhang , Qi Cao , Yunfan Wu , Fei Sun , Huawei Shen , Xueqi Cheng

In this work, we introduce MedAgentSim, an open-source simulated clinical environment with doctor, patient, and measurement agents designed to evaluate and enhance LLM performance in dynamic diagnostic settings. Unlike prior approaches, our…

Computation and Language · Computer Science 2025-10-02 Mohammad Almansoori , Komal Kumar , Hisham Cholakkal

Multimodal clinical reasoning in the field of gastrointestinal (GI) oncology necessitates the integrated interpretation of endoscopic imagery, radiological data, and biochemical markers. Despite the evident potential exhibited by Multimodal…

Agentic systems for drug discovery have demonstrated autonomous synthesis planning, literature mining, and molecular design. We ask how well they generalize. Evaluating six frameworks against 15 task classes drawn from peptide therapeutics,…

Quantitative Methods · Quantitative Biology 2026-02-12 Edward Wijaya