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The translation of comparative genomics into clinical decision support tools often depends on the quality of sequence alignments. However, currently used methods of multiple sequence alignments suffer from significant biases and problems…

Genomics · Quantitative Biology 2023-11-30 Manal Helal , Vitali Sintchenko

This work presents a fully GPU-accelerated algorithm for the polygonal mesh generator known as Polylla. Polylla is a tri-to-polygon mesh generator, which benefits from the half-edge data structure to manage any polygonal shape. The proposed…

Graphics · Computer Science 2024-03-25 Sergio Salinas-Fernández , Nancy Hitschfeld-Kahler , Roberto Carrasco

Sequential robot manipulation tasks require finding collision-free trajectories that satisfy geometric constraints across multiple object interactions in potentially high-dimensional configuration spaces. Solving these problems in real-time…

Robotics · Computer Science 2025-10-14 Lucas Chen , Shrutheesh Raman Iyer , Zachary Kingston

Sequence alignment is a cornerstone of bioinformatics, widely used to identify similarities between DNA, RNA, and protein sequences and studying evolutionary relationships and functional properties. The Needleman-Wunsch algorithm remains a…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-12-31 Linus Zwaka

This paper presents a GPU-accelerated framework for solving block tridiagonal linear systems that arise naturally in numerous real-time applications across engineering and scientific computing. Through a multi-stage permutation strategy…

Optimization and Control · Mathematics 2026-01-08 Roland Schwan , Daniel Kuhn , Colin N. Jones

Sparse General Matrix-Matrix Multiplication (SpGEMM) is a fundamental operation in numerous scientific computing and data analytics applications, often bottlenecked by irregular memory access patterns. This paper presents Hash based…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-16 Shiju Li , Younghoon Min , Hane Yie , Hoshik Kim , Soohong Ahn , Joonseop Sim , Chul-Ho Lee , Jongryool Kim

Deep neural networks are increasingly bottlenecked by the cost of optimization, both in terms of GPU memory and compute time. Existing acceleration techniques, such as mixed precision, second-order methods, and batch size scaling, are…

Machine Learning · Computer Science 2025-09-03 Mohsen Sheibanian , Pouya Shaeri , Alimohammad Beigi , Ryan T. Woo , Aryan Keluskar

Genomics is changing our understanding of humans, evolution, diseases, and medicines to name but a few. As sequencing technology is developed collecting DNA sequences takes less time thereby generating more genetic data every day. Today the…

Quantitative Methods · Quantitative Biology 2020-07-29 Sahand Salamat , Tajana Rosing

Sequence alignment algorithms are a basic and critical component of many bioinformatics fields. With rapid development of sequencing technology, the fast growing reference database volumes and longer length of query sequence become new…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-01-09 Bo Xu , Changlong Li , Hang Zhuang , Jiali Wang , Qingfeng Wang , Jinhong Zhou , Xuehai Zhou

We improve on GenASM, a recent algorithm for genomic sequence alignment, by significantly reducing its memory footprint and bandwidth requirement. Our algorithmic improvements reduce the memory footprint by 24$\times$ and the number of…

Hardware Architecture · Computer Science 2022-03-30 Joël Lindegger , Damla Senol Cali , Mohammed Alser , Juan Gómez-Luna , Onur Mutlu

Subgraph matching has garnered increasing attention for its diverse real-world applications. Given the dynamic nature of real-world graphs, addressing evolving scenarios without incurring prohibitive overheads has been a focus of research.…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-01-31 Linshan Qiu , Lu Chen , Hailiang Jie , Xiangyu Ke , Yunjun Gao , Yang Liu , Zetao Zhang

NSGA-III is one of the most widely adopted algorithms for tackling many-objective optimization problems. However, its CPU-based design severely limits scalability and computational efficiency. To address the limitations, we propose…

Neural and Evolutionary Computing · Computer Science 2025-04-09 Hao Li , Zhenyu Liang , Ran Cheng

Particle Swarm Optimization (PSO) is a stochastic technique for solving the optimization problem. Attempts have been made to shorten the computation times of PSO based algorithms with massive threads on GPUs (graphic processing units),…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-12-05 Chuan-Chi Wang , Chun-Yen Ho , Chia-Heng Tu , Shih-Hao Hung

This paper presents the implementation of a quantum sequence alignment (QSA) algorithm on biological data in environments simulating noisy intermediate-scale quantum (NISQ) computers. The approach to quantum bioinformatics adapts the…

Quantum Physics · Physics 2025-07-02 Floyd M. Creevey , Mingrui Jing , Lloyd C. L. Hollenberg

We present the parallel and interacting stochastic approximation annealing (PISAA) algorithm, a stochastic simulation procedure for global optimisation, that extends and improves the stochastic approximation annealing (SAA) by using…

Computation · Statistics 2015-08-21 Georgios Karagiannis , Bledar A. Konomi , Guang Lin , Faming Liang

Motivation: We introduce SneakySnake, a highly parallel and highly accurate pre-alignment filter that remarkably reduces the need for computationally costly sequence alignment. The key idea of SneakySnake is to reduce the approximate string…

Genomics · Quantitative Biology 2023-11-21 Mohammed Alser , Taha Shahroodi , Juan Gomez-Luna , Can Alkan , Onur Mutlu

We develop an algorithm to solve tridiagonal systems of linear equations, which appear in implicit finite-difference schemes of partial differential equations (PDEs), being the time-dependent Schr\"{o}dinger equation (TDSE) an ideal…

Computational Physics · Physics 2023-03-14 Yaroslav Lutsyshyn , Francisco Navarrete , Dieter Bauer

Block-tridiagonal systems are prevalent in state estimation and optimal control, and solving these systems is often the computational bottleneck. Improving the underlying solvers therefore has a direct impact on the real-time performance of…

Mathematical Software · Computer Science 2025-12-05 David Jin , Alexis Montoison , Sungho Shin

We propose a new method, called a deep-genetic algorithm (deep-GA), to accelerate the performance of the so-called deep-BSDE method, which is a deep learning algorithm to solve high dimensional partial differential equations through their…

Range minimum queries are frequently used in string processing and database applications including biological sequence analysis, document retrieval, and web search. Hence, various data structures have been proposed for improving their…

Databases · Computer Science 2026-04-03 Lara Kreis , Justus Henneberg , Valentin Henkys , Felix Schuhknecht , Bertil Schmidt