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Cellular differentiation and evolution are stochastic processes that can involve multiple types (or states) of particles moving on a complex, high-dimensional state-space or "fitness" landscape. Cells of each specific type can thus be…
Pre-routing timing prediction has been recently studied for evaluating the quality of a candidate cell placement in chip design. It involves directly estimating the timing metrics for both pin-level (slack, slew) and edge-level (net delay,…
Real-world image super-resolution (Real-ISR) must handle complex degradations and inherent reconstruction ambiguities. While generative models have improved perceptual quality, a key trade-off remains with computational cost. One-step…
Industrial design evaluation often relies on high-fidelity simulations of governing partial differential equations (PDEs). While accurate, these simulations are computationally expensive, making dense exploration of design spaces…
We study transfer learning for a linear regression task using several least-squares pretrained models that can be overparameterized. We formulate the target learning task as optimization that minimizes squared errors on the target dataset…
Gene transcription is a highly stochastic and dynamic process. As a result, the mRNA copy number of a given gene is heterogeneous both between cells and across time. We present a framework to model gene transcription in populations of cells…
Pretraining on large-scale collections of PDE-governed spatiotemporal trajectories has recently shown promise for building generalizable models of dynamical systems. Yet most existing PDE foundation models rely on deterministic Transformer…
Neural controlled differential equations (CDEs) are the continuous-time analogue of recurrent neural networks, as Neural ODEs are to residual networks, and offer a memory-efficient continuous-time way to model functions of potentially…
Microstructure evolution, which plays a critical role in determining materials properties, is commonly simulated by the high-fidelity but computationally expensive phase-field method. To address this, we approximate microstructure evolution…
This paper develops a generative statistical model for representing, modeling, and comparing the morphological evolution of biological cells undergoing motility. It uses the elastic shape analysis to separate cell kinematics (overall…
We propose a novel framework for analyzing the dynamics of distribution shift in real-world systems that captures the feedback loop between learning algorithms and the distributions on which they are deployed. Prior work largely models…
Automated cellular instance segmentation is a process utilized for accelerating biological research for the past two decades, and recent advancements have produced higher quality results with less effort from the biologist. Most current…
Despite the great progress in 3D human pose estimation from videos, it is still an open problem to take full advantage of a redundant 2D pose sequence to learn representative representations for generating one 3D pose. To this end, we…
We explore an error-bounded lossy compression approach for reducing scientific data associated with 2D/3D unstructured meshes. While existing lossy compressors offer a high compression ratio with bounded error for regular grid data,…
In this work, we address two limitations of existing conditional diffusion models: their slow inference speed due to the iterative denoising process and their reliance on paired data for model fine-tuning. To tackle these issues, we…
The quantification of emotional states is an important step to understanding wellbeing. Time series data from multiple modalities such as physiological and motion sensor data have proven to be integral for measuring and quantifying…
Generative modeling of anatomical structures plays a crucial role in virtual imaging trials, which allow researchers to perform studies without the costs and constraints inherent to in vivo and phantom studies. For clinical relevance,…
This paper revisits the neural vocoder task through the lens of audio restoration and propose a novel diffusion vocoder called BridgeVoC. Specifically, by rank analysis, we compare the rank characteristics of Mel-spectrum with other common…
Microstructural evolution is a key aspect of understanding and exploiting the structure-property-performance relation of materials. Modeling microstructure evolution usually relies on coarse-grained simulations with evolution principles…
We propose to use a simulation driven inverse inference approach to model the dynamics of tree branches under manipulation. Learning branch dynamics and gaining the ability to manipulate deformable vegetation can help with occlusion-prone…