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Background: High-resolution MRI is critical for diagnosis, but long acquisition times limit clinical use. Super-resolution (SR) can enhance resolution post-scan, yet existing deep learning methods face fidelity-efficiency trade-offs.…

Large language models (LLMs) have revolutionized natural language processing and are increasingly applied to other sequential data types, including genetic sequences. However, adapting LLMs to genomics presents significant challenges.…

Machine Learning · Computer Science 2025-10-29 Qihao Duan , Bingding Huang , Zhenqiao Song , Irina Lehmann , Lei Gu , Roland Eils , Benjamin Wild

We re-examine the evolutionary dynamics of RNA secondary structures under directional selection towards an optimum RNA structure. We find that the punctuated equilibria lead to a very slow approach to the optimum, following on average an…

Populations and Evolution · Quantitative Biology 2010-11-05 P. Sulc , A. Wagner , O. C. Martin

Recent years have witnessed growing interest in the application of deep neural networks (DNNs) for receiver design, which can potentially be applied in complex environments without relying on knowledge of the channel model. However, the…

Information Theory · Computer Science 2023-02-14 Tomer Raviv , Sangwoo Park , Osvaldo Simeone , Yonina C. Eldar , Nir Shlezinger

Sequential Recommendation (SR) models infer user preferences from interaction histories. While transferable Multi-modal SR models outperform traditional ID-based approaches, existing methods struggle with slow fine-tuning convergence due to…

Information Retrieval · Computer Science 2026-03-30 Hao Fan , Qingyang Liu , Hongjiu Liu , Yanrong Hu , Kai Fang

Two-way relaying networks (TWRNs) allow for more bandwidth efficient use of the available spectrum since they allow for simultaneous information exchange between two users with the assistance of an intermediate relay node. However, due to…

Information Theory · Computer Science 2016-11-18 Ali Arshad Nasir , Hani Mehrpouyan , Salman Durrani , Steven D. Blostein , Rodney A. Kennedy

The design of biological systems is hindered by uncertainty arising from both intrinsic stochasticity of biomolecular reactions and variability across laboratory or experimental conditions. In this work, we present a sequential framework to…

Machine Learning · Computer Science 2026-05-08 Michal Kobiela , Diego A. Oyarzún , Michael U. Gutmann

This study introduces a framework that integrates nonlinear feature extraction, classification, and efficient optimization. First, kernel principal component analysis with a radial basis function kernel reduces dimensionality while…

Machine Learning · Computer Science 2025-06-23 Iliyas Ibrahim Iliyas , Souley Boukari , Abdulsalam Yau Gital

The PHASE software package allows phylogenetic tree construction with a number of evolutionary models designed specifically for use with RNA sequences that have conserved secondary structure. Evolution in the paired regions of RNAs occurs…

Populations and Evolution · Quantitative Biology 2007-05-23 Cendrine Hudelot , Vivek Gowri-Shankar , Howsun Jow , Magnus Rattray , Paul G. Higgs

End-to-end design of communication systems using deep autoencoders (AEs) is gaining attention due to its flexibility and excellent performance. Besides single-user transmission, AE-based design is recently explored in multi-user setup,…

Signal Processing · Electrical Eng. & Systems 2023-06-26 Vukan Ninkovic , Dejan Vukobratovic , Adriano Pastore , Carles Anton-Haro

In this study, we introduce an innovative methodology for the design of mm-Wave passive networks that leverages knowledge transfer from a pre-trained synthesis neural network (NN) model in one technology node and achieves swift and reliable…

Signal Processing · Electrical Eng. & Systems 2025-03-12 Chenhao Chu , Yuhao Mao , Hua Wang

RNA's diverse biological functions stem from its structural versatility, yet accurately predicting and designing RNA sequences given a 3D conformation (inverse folding) remains a challenge. Here, I introduce a deep learning framework that…

Quantitative Methods · Quantitative Biology 2026-01-06 Annabelle Yao

Transition Matching (TM) is an emerging paradigm for generative modeling that generalizes diffusion and flow-matching models as well as continuous-state autoregressive models. TM, similar to previous paradigms, gradually transforms noise…

Machine Learning · Computer Science 2025-12-16 Uriel Singer , Yaron Lipman

$\textbf{Purpose:}$ To develop and evaluate an operator learning framework for nonlinear inversion (NLI) of brain magnetic resonance elastography (MRE) data, which enables real-time inversion of elastograms with comparable spatial accuracy…

Image and Video Processing · Electrical Eng. & Systems 2025-10-07 Juampablo E. Heras Rivera , Caitlin M. Neher , Mehmet Kurt

Bilinear Matrix Inequalities (BMIs) are fundamental to control system design but are notoriously difficult to solve due to their nonconvexity. This study addresses BMI-based control optimization problems by adapting and integrating advanced…

Systems and Control · Electrical Eng. & Systems 2026-01-14 Syue-Cian Lin , Wei-Yu Chiu , Chien-Feng Wu

Radiation response in cancer is shaped by complex, patient specific biology, yet current treatment strategies often rely on uniform dose prescriptions without accounting for tumor heterogeneity. In this study, we introduce a meta learning…

Medical Physics · Physics 2025-08-12 Hao Peng , Yuanyuan Zhang , Steve Jiang , Robert Timmerman , John Minna

MicroRNAs (miRNAs) are short sequences of ribonucleic acids that control the expression of target messenger RNAs (mRNAs) by binding them. Robust prediction of miRNA-mRNA pairs is of utmost importance in deciphering gene regulations but has…

Machine Learning · Computer Science 2016-09-27 Byunghan Lee , Junghwan Baek , Seunghyun Park , Sungroh Yoon

A specific challenge with deep learning approaches for molecule generation is generating both syntactically valid and chemically plausible molecular string representations. To address this, we propose a novel generative latent-variable…

Biomolecules · Quantitative Biology 2024-07-22 Ulrich A. Mbou Sob , Qiulin Li , Miguel Arbesú , Oliver Bent , Andries P. Smit , Arnu Pretorius

Magnetic resonance imaging (MRI) is a widely used non-radiative and non-invasive method for clinical interrogation of organ structures and metabolism, with an inherently long scanning time. Methods by k-space undersampling and deep learning…

Image and Video Processing · Electrical Eng. & Systems 2022-04-05 Jiahao Huang , Yinzhe Wu , Huanjun Wu , Guang Yang

Recently, Machine Learning (ML) is recognized as an effective tool for wireless communications and plays an evolutionary role to enhance Physical Layer (PHY) of 5th Generation (5G) and Beyond 5G (B5G) systems. In this paper, we focus on the…

Signal Processing · Electrical Eng. & Systems 2020-11-09 Yejian Chen , Jafar Mohammadi , Stefan Wesemann , Thorsten Wild