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In whole slide images (WSIs) analysis, attention-based multi-instance learning (MIL) models are susceptible to spurious correlations and degrade under domain shift. These methods may assign high attention weights to non-tumor regions, such…

Computer Vision and Pattern Recognition · Computer Science 2025-12-08 Xin Liu , Weijia Zhang , Wei Tang , Thuc Duy Le , Jiuyong Li , Lin Liu , Min-Ling Zhang

Multiple Instance Learning (MIL) is increasingly being used as a support tool within clinical settings for pathological diagnosis decisions, achieving high performance and removing the annotation burden. However, existing approaches for…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Sungrae Hong , Kyungeun Kim , Juhyeon Kim , Sol Lee , Jisu Shin , Chanjae Song , Mun Yong Yi

When using Convolutional Neural Networks (CNNs) for segmentation of organs and lesions in medical images, the conventional approach is to work with inputs and outputs either as single slice (2D) or whole volumes (3D). One common…

Image and Video Processing · Electrical Eng. & Systems 2020-11-17 Minh H. Vu , Guus Grimbergen , Tufve Nyholm , Tommy Löfstedt

Humans can easily identify anatomical planes (axial, coronal, and sagittal) on a 2D MRI slice, but automated systems struggle with this task. Missing plane orientation metadata can complicate analysis, increase domain shift when merging…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 SangHyuk Kim , Daniel Haehn , Sumientra Rampersad

Brain tumor segmentation is important for diagnosis of the tumor, and current deep-learning methods rely on a large set of annotated images for training, with high annotation costs. Unsupervised segmentation is promising to avoid human…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Xiaochuan Ma , Jia Fu , Wenjun Liao , Shichuan Zhang , Guotai Wang

Traditional image-based survival prediction models rely on discriminative patch labeling which make those methods not scalable to extend to large datasets. Recent studies have shown Multiple Instance Learning (MIL) framework is useful for…

Image and Video Processing · Electrical Eng. & Systems 2020-09-24 Jiawen Yao , Xinliang Zhu , Jitendra Jonnagaddala , Nicholas Hawkins , Junzhou Huang

Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). However, existing approaches typically rely on pre-trained models from large natural image datasets, such as…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Yi Lin , Zhongchen Zhao , Zhengjie ZHU , Lisheng Wang , Kwang-Ting Cheng , Hao Chen

Deep learning-based segmentation techniques have shown remarkable performance in brain segmentation, yet their success hinges on the availability of extensive labeled training data. Acquiring such vast datasets, however, poses a significant…

Computer Vision and Pattern Recognition · Computer Science 2024-07-18 Jihoon Cho , Suhyun Ahn , Beomju Kim , Hyungjoon Bae , Xiaofeng Liu , Fangxu Xing , Kyungeun Lee , Georges Elfakhri , Van Wedeen , Jonghye Woo , Jinah Park

Multiple Instance Learning (MIL) offers a natural solution for settings where only coarse, bag-level labels are available, without having access to instance-level annotations. This is usually the case in digital pathology, which consists of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Andreas Lolos , Stergios Christodoulidis , Aris L. Moustakas , Jose Dolz , Maria Vakalopoulou

Detecting anomalies over real-world datasets remains a challenging task. Data annotation is an intensive human labor problem, particularly in sequential datasets, where the start and end time of anomalies are not known. As a result, data…

Machine Learning · Computer Science 2022-10-05 Parastoo Kamranfar , David Lattanzi , Amarda Shehu , Daniel Barbará

Convolutional neural networks can be trained to perform histology slide classification using weak annotations with multiple instance learning (MIL). However, given the paucity of labeled histology data, direct application of MIL can easily…

Computer Vision and Pattern Recognition · Computer Science 2019-11-05 Ming Y. Lu , Richard J. Chen , Jingwen Wang , Debora Dillon , Faisal Mahmood

Multiple Instance Learning (MIL) has been widely applied in pathology towards solving critical problems such as automating cancer diagnosis and grading, predicting patient prognosis, and therapy response. Deploying these models in a…

Computer Vision and Pattern Recognition · Computer Science 2022-10-18 Syed Ashar Javed , Dinkar Juyal , Harshith Padigela , Amaro Taylor-Weiner , Limin Yu , Aaditya Prakash

Segmenting tumors in histological images is vital for cancer diagnosis. While fully supervised models excel with pixel-level annotations, creating such annotations is labor-intensive and costly. Accurate histopathology image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Yinsheng He , Xingyu Li , Roger J. Zemp

Computational pathology involves the digitization of stained tissues into whole-slide images (WSIs) that contain billions of pixels arranged as contiguous patches. Statistical analysis of WSIs largely focuses on classification via multiple…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 So Won Jeong , Veronika Ročková

With the increasing demand for histopathological specimen examination and diagnostic reporting, Multiple Instance Learning (MIL) has received heightened research focus as a viable solution for AI-centric diagnostic aid. Recently, to improve…

Computer Vision and Pattern Recognition · Computer Science 2025-12-25 Sungrae Hong , Sol Lee , Jisu Shin , Jiwon Jeong , Mun Yong Yi

Accurate cancer diagnosis remains a critical challenge in digital pathology, largely due to the gigapixel size and complex spatial relationships present in whole slide images. Traditional multiple instance learning (MIL) methods often…

Computer Vision and Pattern Recognition · Computer Science 2024-04-18 Kechun Liu , Wenjun Wu , Joann G. Elmore , Linda G. Shapiro

Multiple instance learning (MIL) significantly reduced annotation costs via bag-level weak labels for large-scale images, such as histopathological whole slide images (WSIs). However, its adaptability to continual tasks with minimal…

Computer Vision and Pattern Recognition · Computer Science 2025-07-09 Byung Hyun Lee , Wongi Jeong , Woojae Han , Kyoungbun Lee , Se Young Chun

In this paper we propose a novel deep learning-based algorithm for biomedical image segmentation which uses a sequential attention mechanism able to shift the focus of attention across the image in a selective way, allowing subareas which…

Computer Vision and Pattern Recognition · Computer Science 2019-09-30 Shohei Hayashi , Bisser Raytchev , Toru Tamaki , Kazufumi Kaneda

Image normalization is a building block in medical image analysis. Conventional approaches are customarily utilized on a per-dataset basis. This strategy, however, prevents the current normalization algorithms from fully exploiting the…

Machine Learning · Computer Science 2020-10-06 Pierre-Luc Delisle , Benoit Anctil-Robitaille , Christian Desrosiers , Herve Lombaert

Lesion appearance is a crucial clue for medical providers to distinguish referable diabetic retinopathy (rDR) from non-referable DR. Most existing large-scale DR datasets contain only image-level labels rather than pixel-based annotations.…

Image and Video Processing · Electrical Eng. & Systems 2022-10-13 Wenhui Zhu , Peijie Qiu , Natasha Lepore , Oana M. Dumitrascu , Yalin Wang