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Despite being resource-intensive to train, 3D convolutional neural networks (CNNs) have been the standard approach to classify CT and MRI scans. Recent work suggests that deep multiple instance learning (MIL) may be a more efficient…

Machine Learning · Computer Science 2026-04-30 Ethan Harvey , Dennis Johan Loevlie , Amir Ali Satani , Wansu Chen , David M. Kent , Michael C. Hughes

The Multiple Instance Learning (MIL) paradigm is attracting plenty of attention in medical imaging classification, where labeled data is scarce. MIL methods cast medical images as bags of instances (e.g. patches in whole slide images, or…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Francisco M. Castro-Macías , Pablo Morales-Álvarez , Yunan Wu , Rafael Molina , Aggelos K. Katsaggelos

Multiple instance learning (MIL) is a supervised learning methodology that aims to allow models to learn instance class labels from bag class labels, where a bag is defined to contain multiple instances. MIL is gaining traction for learning…

Computer Vision and Pattern Recognition · Computer Science 2019-11-14 Samuel W. Remedios , Zihao Wu , Camilo Bermudez , Cailey I. Kerley , Snehashis Roy , Mayur B. Patel , John A. Butman , Bennett A. Landman , Dzung L. Pham

3D image segmentation is one of the most important and ubiquitous problems in medical image processing. It provides detailed quantitative analysis for accurate disease diagnosis, abnormal detection, and classification. Currently deep…

Computer Vision and Pattern Recognition · Computer Science 2019-06-19 Zhenxi Zhang , Jie Li , Zhusi Zhong , Zhicheng Jiao , Xinbo Gao

Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

Quantitative Methods · Quantitative Biology 2025-03-14 Rajiv Krishnakumar , Julien Baglio , Frederik F. Flöther , Christian Ruiz , Stefan Habringer , Nicole H. Romano

Multiple instance learning (MIL) is often used in medical imaging to classify high-resolution 2D images by processing patches or classify 3D volumes by processing slices. However, conventional MIL approaches treat instances separately,…

Machine Learning · Computer Science 2025-11-13 Ethan Harvey , Dennis Johan Loevlie , Michael C. Hughes

Multiple Instance Learning (MIL) has been widely applied to medical imaging diagnosis, where bag labels are known and instance labels inside bags are unknown. Traditional MIL assumes that instances in each bag are independent samples from a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-19 Yunan Wu , Francisco M. Castro-Macías , Pablo Morales-Álvarez , Rafael Molina , Aggelos K. Katsaggelos

Multi-instance learning (MIL) is widely used in the computer-aided interpretation of pathological Whole Slide Images (WSIs) to solve the lack of pixel-wise or patch-wise annotations. Often, this approach directly applies "natural image…

Anomaly detection and classification in medical imaging are critical for early diagnosis but remain challenging due to limited annotated data, class imbalance, and the high cost of expert labeling. Emerging vision foundation models such as…

Image and Video Processing · Electrical Eng. & Systems 2025-09-17 Fazle Rafsani , Jay Shah , Catherine D. Chong , Todd J. Schwedt , Teresa Wu

In many histopathology tasks, sample classification depends on morphological details in tissue or single cells that are only visible at the highest magnification. For a pathologist, this implies tedious zooming in and out, while for a…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Ario Sadafi , Nassir Navab , Carsten Marr

Pancreatic ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the United States. Predicting tumors like PDACs (including both classification and segmentation) from medical images by deep learning is becoming a…

Computer Vision and Pattern Recognition · Computer Science 2021-06-01 Yan Wang , Peng Tang , Yuyin Zhou , Wei Shen , Elliot K. Fishman , Alan L. Yuille

Medical image analysis requires substantial labeled data for model training, yet expert annotation is expensive and time-consuming. Active learning (AL) addresses this challenge by strategically selecting the most informative samples for…

Image and Video Processing · Electrical Eng. & Systems 2026-03-06 Ifrat Ikhtear Uddin , Longwei Wang , Xiao Qin , Yang Zhou , KC Santosh

Multiple instance learning (MIL) can reduce the need for costly annotation in tasks such as semantic segmentation by weakening the required degree of supervision. We propose a novel MIL formulation of multi-class semantic segmentation…

Computer Vision and Pattern Recognition · Computer Science 2015-04-16 Deepak Pathak , Evan Shelhamer , Jonathan Long , Trevor Darrell

Detection faults in seismic data is a crucial step for seismic structural interpretation, reservoir characterization and well placement. Some recent works regard it as an image segmentation task. The task of image segmentation requires huge…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 YiMin Dou , Kewen Li , Jianbing Zhu , Xiao Li , Yingjie Xi

Multiple instance learning (MIL) is the standard approach for whole-slide image (WSI) classification and survival prediction, where attention-based models ag gregate patch features into slide-level predictions. These models treat attention…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Xiangyu Li , Ran Su

In many review classification applications, a fine-grained analysis of the reviews is desirable, because different segments (e.g., sentences) of a review may focus on different aspects of the entity in question. However, training supervised…

Machine Learning · Computer Science 2019-10-02 Giannis Karamanolakis , Daniel Hsu , Luis Gravano

Multi-label image classification allows predicting a set of labels from a given image. Unlike multiclass classification, where only one label per image is assigned, such a setup is applicable for a broader range of applications. In this…

Computer Vision and Pattern Recognition · Computer Science 2022-12-21 Kirill Prokofiev , Vladislav Sovrasov

Attention-based multiple instance learning (MIL) has emerged as a powerful framework for whole slide image (WSI) diagnosis, leveraging attention to aggregate instance-level features into bag-level predictions. Despite this success, we find…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Linfeng Ye , Shayan Mohajer Hamidi , Zhixiang Chi , Guang Li , Mert Pilanci , Takahiro Ogawa , Miki Haseyama , Konstantinos N. Plataniotis

Multiple instance learning (MIL) is a robust paradigm for whole-slide pathological image (WSI) analysis, processing gigapixel-resolution images with slide-level labels. As pioneering efforts, attention-based MIL (ABMIL) and its variants are…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Linghan Cai , Shenjin Huang , Ye Zhang , Jinpeng Lu , Yongbing Zhang

Breast cancer prediction models for mammography assume that annotations are available for individual images or regions of interest (ROIs), and that there is a fixed number of images per patient. These assumptions do not hold in real…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Shreyasi Pathak , Jörg Schlötterer , Jeroen Geerdink , Jeroen Veltman , Maurice van Keulen , Nicola Strisciuglio , Christin Seifert
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