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The convergence of statistical learning and molecular physics is transforming our approach to modeling biomolecular systems. Physics-informed machine learning (PIML) offers a systematic framework that integrates data-driven inference with…

Biomolecules · Quantitative Biology 2025-11-11 Aaryesh Deshpande

Physics-informed machine learning (PIML) is a set of methods and tools that systematically integrate machine learning (ML) algorithms with physical constraints and abstract mathematical models developed in scientific and engineering…

Physics-informed machine learning (PIML) integrates partial differential equations (PDEs) into machine learning models to solve inverse problems, such as estimating coefficient functions (e.g., the Hamiltonian function) that characterize…

Computational Physics · Physics 2025-11-07 Yoh-ichi Mototake , Makoto Sasaki

Physics-informed machine learning (PIML) is an emerging framework that integrates physical knowledge into machine learning models. This physical prior often takes the form of a partial differential equation (PDE) system that the regression…

Machine Learning · Statistics 2025-07-15 Nathan Doumèche

Physics-informed machine learning (PIML) integrates prior physical information, often in the form of differential equation constraints, into the process of fitting machine learning models to physical data. Popular PIML approaches, including…

Machine Learning · Statistics 2025-10-31 Mara Daniels , Liam Hodgkinson , Michael Mahoney

Physics-Informed Machine Learning (PIML) has gained momentum in the last 5 years with scientists and researchers aiming to utilize the benefits afforded by advances in machine learning, particularly in deep learning. With large scientific…

Computational Physics · Physics 2021-05-26 Samuel J. Raymond , David B. Camarillo

Physics-informed machine learning (PIML), referring to the combination of prior knowledge of physics, which is the high level abstraction of natural phenomenons and human behaviours in the long history, with data-driven machine learning…

Machine Learning · Computer Science 2022-04-01 Chuizheng Meng , Sungyong Seo , Defu Cao , Sam Griesemer , Yan Liu

Recent advances of data-driven machine learning have revolutionized fields like computer vision, reinforcement learning, and many scientific and engineering domains. In many real-world and scientific problems, systems that generate data are…

Machine Learning · Computer Science 2023-03-08 Zhongkai Hao , Songming Liu , Yichi Zhang , Chengyang Ying , Yao Feng , Hang Su , Jun Zhu

Physics-informed machine learning typically integrates physical priors into the learning process by minimizing a loss function that includes both a data-driven term and a partial differential equation (PDE) regularization. Building on the…

Machine Learning · Statistics 2025-09-23 Nathan Doumèche , Francis Bach , Gérard Biau , Claire Boyer

This study presents a comprehensive overview of PIML techniques in the context of condition monitoring. The central concept driving PIML is the incorporation of known physical laws and constraints into machine learning algorithms, enabling…

Machine Learning · Computer Science 2024-01-23 Yuandi Wu , Brett Sicard , Stephen Andrew Gadsden

Physics-informed machine learning (PIML) as a means of solving partial differential equations (PDE) has garnered much attention in the Computational Science and Engineering (CS&E) world. This topic encompasses a broad array of methods and…

Machine Learning · Computer Science 2024-09-05 Michael Penwarden , Houman Owhadi , Robert M. Kirby

Physics-Informed Machine Learning (PIML) offers a powerful paradigm of integrating data with physical laws to address important scientific problems, such as parameter estimation, inferring hidden physics, equation discovery, and state…

Computational Engineering, Finance, and Science · Computer Science 2025-10-31 Letian Yi , Siyuan Yang , Ying Cui , Zhilu Lai

Physics-informed machine learning (PIML) represents an emerging paradigm that integrates various forms of physical knowledge into machine learning (ML) components, thereby enhancing the physical consistency of ML models compared to purely…

Chemical Physics · Physics 2025-10-28 Jiahao Wu , Xutun Wang , Guihua Zhang , Jiayue Liu , Xin Li , Yang Zhang , Hai Zhang , Junfu Lyu , Bing Wang , Yuxin Wu

Physics-informed machine learning (PIML) has emerged as a promising new approach for simulating complex physical and biological systems that are governed by complex multiscale processes for which some data are also available. In some…

Machine Learning · Computer Science 2022-05-18 Khemraj Shukla , Mengjia Xu , Nathaniel Trask , George Em Karniadakis

There is growing interest in using machine learning (ML) methods for structural metamodeling due to the substantial computational cost of traditional simulations. Purely data-driven strategies often face limitations in model robustness,…

Applied Physics · Physics 2024-04-30 R. Bailey Bond , Pu Ren , Jerome F. Hajjar , Hao Sun

The unprecedented amount of data generated from experiments, field observations, and large-scale numerical simulations at a wide range of spatio-temporal scales have enabled the rapid advancement of data-driven and especially deep learning…

Computational Physics · Physics 2024-06-19 Suraj Pawar , Omer San , Aditya Nair , Adil Rasheed , Trond Kvamsdal

Compared to physics-based computational manufacturing, data-driven models such as machine learning (ML) are alternative approaches to achieve smart manufacturing. However, the data-driven ML's "black box" nature has presented a challenge to…

Machine Learning · Computer Science 2024-07-16 Rahul Sharma , Maziar Raissi , Y. B. Guo

We present a novel approach to modeling the ground state mass of atomic nuclei based directly on a probabilistic neural network constrained by relevant physics. Our Physically Interpretable Machine Learning (PIML) approach incorporates…

Nuclear Theory · Physics 2022-08-17 M. R. Mumpower , T. M. Sprouse , A. E. Lovell , A. T. Mohan

Quantifying and propagating modeling uncertainties is crucial for reliability analysis, robust optimization, and other model-based algorithmic processes in engineering design and control. Now, physics-informed machine learning (PIML)…

Machine Learning · Computer Science 2025-07-14 Manaswin Oddiraju , Bharath Varma Penumatsa , Divyang Amin , Michael Piedmonte , Souma Chowdhury

We present a physics-informed machine learning (PIML) scheme for the feedback linearization of nonlinear discrete-time dynamical systems. The PIML finds the nonlinear transformation law, thus ensuring stability via pole placement, in one…

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