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Conditional variational autoencoders (CVAEs) are versatile deep generative models that extend the standard VAE framework by conditioning the generative model with auxiliary covariates. The original CVAE model assumes that the data samples…

Machine Learning · Statistics 2022-03-03 Siddharth Ramchandran , Gleb Tikhonov , Otto Lönnroth , Pekka Tiikkainen , Harri Lähdesmäki

We propose to meta-learn causal structures based on how fast a learner adapts to new distributions arising from sparse distributional changes, e.g. due to interventions, actions of agents and other sources of non-stationarities. We show…

Generative model-based motion prediction techniques have recently realized predicting controlled human motions, such as predicting multiple upper human body motions with similar lower-body motions. However, to achieve this, the…

Computer Vision and Pattern Recognition · Computer Science 2022-07-05 Chunzhi Gu , Jun Yu , Chao Zhang

On time-series data, most causal discovery methods fit a new model whenever they encounter samples from a new underlying causal graph. However, these samples often share relevant information which is lost when following this approach.…

Machine Learning · Computer Science 2022-02-24 Sindy Löwe , David Madras , Richard Zemel , Max Welling

We present a constraint-based algorithm for learning causal structures from observational time-series data, in the presence of latent confounders. We assume a discrete-time, stationary structural vector autoregressive process, with both…

Artificial Intelligence · Computer Science 2023-06-02 Raanan Y. Rohekar , Shami Nisimov , Yaniv Gurwicz , Gal Novik

Recent advances in electron, scanning probe, optical, and chemical imaging and spectroscopy yield bespoke data sets containing the information of structure and functionality of complex systems. In many cases, the resulting data sets are…

Materials Science · Physics 2024-11-15 Yongtao Liu , Bryan D Huey , Maxim A. Ziatdinov , Sergei V. Kalinin

Single-cell RNA sequencing (scRNA-seq) has revealed complex cellular heterogeneity, but recent studies emphasize that understanding biological function also requires modeling cell-cell communication (CCC), the signaling interactions…

Machine Learning · Computer Science 2025-12-29 Cong Qi , Yeqing Chen , Zhi Wei

Gene regulatory networks play a crucial role in controlling an organism's biological processes, which is why there is significant interest in developing computational methods that are able to extract their structure from high-throughput…

Machine Learning · Statistics 2019-09-11 Ioan Gabriel Bucur , Tom Claassen , Tom Heskes

Deep generative models have been enjoying success in modeling continuous data. However it remains challenging to capture the representations for discrete structures with formal grammars and semantics, e.g., computer programs and molecular…

Machine Learning · Computer Science 2018-02-27 Hanjun Dai , Yingtao Tian , Bo Dai , Steven Skiena , Le Song

In many fields$\unicode{x2013}$including genomics, epidemiology, natural language processing, social and behavioral sciences, and economics$\unicode{x2013}$it is increasingly important to address causal questions in the context of factor…

Methodology · Statistics 2025-06-30 Jenna M. Landy , Dafne Zorzetto , Roberta De Vito , Giovanni Parmigiani

Learning interpretable and disentangled representations of data is a key topic in machine learning research. Variational Autoencoder (VAE) is a scalable method for learning directed latent variable models of complex data. It employs a clear…

Machine Learning · Computer Science 2020-06-04 Andriy Serdega , Dae-Shik Kim

Representation disentanglement is an important goal of representation learning that benefits various downstream tasks. To achieve this goal, many unsupervised learning representation disentanglement approaches have been developed. However,…

Machine Learning · Computer Science 2022-09-23 Jiageng Zhu , Hanchen Xie , Wael Abd-Almageed

Single-step retrosynthesis is the cornerstone of retrosynthesis planning, which is a crucial task for computer-aided drug discovery. The goal of single-step retrosynthesis is to identify the possible reactants that lead to the synthesis of…

Quantitative Methods · Quantitative Biology 2022-08-12 Huarui He , Jie Wang , Yunfei Liu , Feng Wu

Root causal analysis seeks to identify the set of initial perturbations that induce an unwanted outcome. In prior work, we defined sample-specific root causes of disease using exogenous error terms that predict a diagnosis in a structural…

Machine Learning · Statistics 2022-10-28 Eric V. Strobl , Thomas A. Lasko

Structured variational autoencoders (SVAEs) combine probabilistic graphical model priors on latent variables, deep neural networks to link latent variables to observed data, and structure-exploiting algorithms for approximate posterior…

Machine Learning · Statistics 2023-05-29 Yixiu Zhao , Scott W. Linderman

Real-world time series exhibit temporally structured uncertainty: volatility clusters in turbulent regimes, dissipates in stable periods, and shifts abruptly around structural breaks. Yet many probabilistic forecasting methods estimate…

Machine Learning · Computer Science 2026-05-26 Yijun Wang , Qiyuan Zhuang , Xiu-Shen Wei

In many problems, the measured variables (e.g., image pixels) are just mathematical functions of the latent causal variables (e.g., the underlying concepts or objects). For the purpose of making predictions in changing environments or…

Machine Learning · Computer Science 2024-08-13 Kun Zhang , Shaoan Xie , Ignavier Ng , Yujia Zheng

We aim to explicitly model the delayed Granger causal effects based on multivariate Hawkes processes. The idea is inspired by the fact that a causal event usually takes some time to exert an effect. Studying this time lag itself is of…

Machine Learning · Computer Science 2023-08-14 Chao Yang , Hengyuan Miao , Shuang Li

Bayesian forecasting is developed in multivariate time series analysis for causal inference. Causal evaluation of sequentially observed time series data from control and treated units focuses on the impacts of interventions using…

Methodology · Statistics 2024-06-21 Graham Tierney , Christoph Hellmayr , Greg Barkimer , Kevin Li , Mike West

Biological foundation models have shown strong performance in single-cell representation learning by applying transformer architectures directly to gene-expression matrices. However, these approaches predominantly operate in static settings…

Machine Learning · Computer Science 2026-05-28 Manuel Dileo , Andrea Sottoriva
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