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Computational drug repurposing for rare diseases is especially challenging when no prior associations exist between drugs and target diseases. Therefore, knowledge graph completion and message-passing GNNs have little reliable signal to…

Artificial Intelligence · Computer Science 2025-10-17 Lang Qin , Zijian Gan , Xu Cao , Pengcheng Jiang , Yankai Jiang , Jiawei Han , Kaishun Wu , Jintai Chen

We study sequential multi-issue trading between two greedily rational agents who exchange resources from a finite set of categories. Each agent's utility depends on its allocation, but the offering agent does not know the responding agent's…

Multiagent Systems · Computer Science 2026-05-15 Surya Murthy , Mustafa O. Karabag , Ufuk Topcu

The development of reinforced learning methods has extended application to many areas including algorithmic trading. In this paper trading on the stock exchange is interpreted into a game with a Markov property consisting of states,…

Trading and Market Microstructure · Quantitative Finance 2020-02-28 Evgeny Ponomarev , Ivan Oseledets , Andrzej Cichocki

Large language models (LLMs) have achieved impressive results in natural language understanding, yet their reasoning capabilities remain limited when operating as single agents. Multi-Agent Debate (MAD) has been proposed to address this…

Computation and Language · Computer Science 2026-03-25 Xiao Wang , Jia Wang , Yijie Wang , Pengtao Dang , Sha Cao , Chi Zhang

This paper develops a novel multi-agent reinforcement learning (MARL) framework for reinsurance treaty bidding, addressing long-standing inefficiencies in traditional broker-mediated placement processes. We pose the core research question:…

Artificial Intelligence · Computer Science 2026-03-24 Stella C. Dong , James R. Finlay

Persistent monitoring of dynamic targets is essential in real-world applications such as disaster response, environmental sensing, and wildlife conservation, where mobile agents must continuously gather information under uncertainty. We…

Multiagent Systems · Computer Science 2025-10-21 Xingjian Zhang , Yizhuo Wang , Guillaume Sartoretti

An autonomous and resilient controller is proposed for leader-follower multi-agent systems under uncertainties and cyber-physical attacks. The leader is assumed non-autonomous with a nonzero control input, which allows changing the team…

Multiagent Systems · Computer Science 2018-04-10 Rohollah Moghadam , Hamidreza Modares

Autonomous agents have demonstrated significant potential in automating complex multistep decision-making tasks. However, even state-of-the-art vision-language models (VLMs), such as GPT-4o, still fall short of human-level performance,…

Computation and Language · Computer Science 2025-03-03 Xiao Yu , Baolin Peng , Vineeth Vajipey , Hao Cheng , Michel Galley , Jianfeng Gao , Zhou Yu

The multi-agent setting is intricate and unpredictable since the behaviors of multiple agents influence one another. To address this environmental uncertainty, distributional reinforcement learning algorithms that incorporate uncertainty…

Machine Learning · Computer Science 2023-03-06 Jihwan Oh , Joonkee Kim , Minchan Jeong , Se-Young Yun

In order for agents in multi-agent systems (MAS) to be safe, they need to take into account the risks posed by the actions of other agents. However, the dominant paradigm in game theory (GT) assumes that agents are not affected by risk from…

Machine Learning · Computer Science 2023-03-03 Oliver Slumbers , David Henry Mguni , Stephen Marcus McAleer , Stefano B. Blumberg , Jun Wang , Yaodong Yang

Multi-agent systems (MAS) are widely prevalent and crucially important in numerous real-world applications, where multiple agents must make decisions to achieve their objectives in a shared environment. Despite their ubiquity, the…

Multiagent Systems · Computer Science 2024-07-04 Dom Huh , Prasant Mohapatra

Large language models (LLMs) have demonstrated remarkable capabilities across diverse tasks, and LLM-based agents further extend these abilities to various practical workflows. While recent progress shows that multi-agent systems (MAS) can…

Computation and Language · Computer Science 2025-10-10 Zheyuan Zhang , Lin Ge , Hongjiang Li , Weicheng Zhu , Chuxu Zhang , Yanfang Ye

Empirical game-theoretic analysis (EGTA) has recently been applied successfully to analyze the behavior of large numbers of competing traders in a continuous double auction market. Multiagent simulation methods like EGTA are useful for…

Artificial Intelligence · Computer Science 2016-04-25 Mason Wright

Multi-agent reinforcement learning (MARL) is a powerful paradigm for solving cooperative and competitive decision-making problems. While many MARL benchmarks have been proposed, few combine continuous state and action spaces with…

Artificial Intelligence · Computer Science 2025-11-18 Artem Pshenitsyn , Aleksandr Panov , Alexey Skrynnik

Reliability in multi-agent systems (MAS) built on large language models is increasingly limited by cognitive failures rather than infrastructure faults. Existing observability tools describe failures but do not quantify how quickly…

Multiagent Systems · Computer Science 2025-12-30 Barak Or

This paper addresses the challenges of rapid resource variation and highly uncertain task loads in cloud computing environments. It proposes an optimization method for elastic cloud resource scaling based on a multi-agent system. The method…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-02 Bruce Fang , Danyi Gao

In this work we consider a generalization of the well-known multivehicle routing problem: given a network, a set of agents occupying a subset of its nodes, and a set of tasks, we seek a minimum cost sequence of movements subject to the…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-02-27 Jamison W. Weber , Dhanush R. Giriyan , Devendra R. Parkar , Dimitri P. Bertsekas , Andréa W. Richa

Dynamic portfolio optimization is the process of sequentially allocating wealth to a collection of assets in some consecutive trading periods, based on investors' return-risk profile. Automating this process with machine learning remains a…

Machine Learning · Computer Science 2019-01-28 Pengqian Yu , Joon Sern Lee , Ilya Kulyatin , Zekun Shi , Sakyasingha Dasgupta

There exist many algorithms for learning how to play repeated bimatrix games. Most of these algorithms are justified in terms of some sort of theoretical guarantee. On the other hand, little is known about the empirical performance of these…

Computer Science and Game Theory · Computer Science 2014-02-03 Erik Zawadzki , Asher Lipson , Kevin Leyton-Brown

Before taking actions in an environment with more than one intelligent agent, an autonomous agent may benefit from reasoning about the other agents and utilizing a notion of a guarantee or confidence about the behavior of the system. In…

Machine Learning · Computer Science 2024-02-12 Nikunj Gupta , Somjit Nath , Samira Ebrahimi Kahou