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Predicting protein function from amino acid sequence remains a central challenge in data-scarce (low-$N$) regimes, limiting machine learning-guided protein design when only small amounts of assay-labeled sequence-function data are…

Machine Learning · Computer Science 2025-08-27 Darin Tsui , Kunal Talreja , Amirali Aghazadeh

Decomposing model activations into interpretable components is a key open problem in mechanistic interpretability. Sparse autoencoders (SAEs) are a popular method for decomposing the internal activations of trained transformers into sparse,…

Machine Learning · Computer Science 2024-06-26 Connor Kissane , Robert Krzyzanowski , Joseph Isaac Bloom , Arthur Conmy , Neel Nanda

Sparse Autoencoder (SAE) has emerged as a powerful tool for mechanistic interpretability of large language models. Recent works apply SAE to protein language models (PLMs), aiming to extract and analyze biologically meaningful features from…

Quantitative Methods · Quantitative Biology 2026-01-21 Xiangyu Liu , Haodi Lei , Yi Liu , Yang Liu , Wei Hu

Large Reasoning Models (LRMs) exhibit human-like cognitive reasoning strategies (e.g. backtracking, cross-verification) during reasoning process, which improves their performance on complex tasks. Currently, reasoning strategies are…

Artificial Intelligence · Computer Science 2026-01-08 Yi Fang , Wenjie Wang , Mingfeng Xue , Boyi Deng , Fengli Xu , Dayiheng Liu , Fuli Feng

Sparse autoencoders (SAEs) have emerged as a powerful tool for uncovering interpretable features in large language models (LLMs) through the sparse directions they learn. However, the sheer number of extracted directions makes comprehensive…

Computation and Language · Computer Science 2025-11-11 Xinyuan Yan , Shusen Liu , Kowshik Thopalli , Bei Wang

Sparse autoencoders (SAEs) have lately been used to uncover interpretable latent features in large language models. By projecting dense embeddings into a much higher-dimensional and sparse space, learned features become disentangled and…

Machine Learning · Computer Science 2025-07-30 Viktoria Schuster

Recent developments in Large Language Model (LLM) capabilities have brought great potential but also posed new risks. For example, LLMs with knowledge of bioweapons, advanced chemistry, or cyberattacks could cause violence if placed in the…

Machine Learning · Computer Science 2025-03-17 Matthew Khoriaty , Andrii Shportko , Gustavo Mercier , Zach Wood-Doughty

Recent work has found that sparse autoencoders (SAEs) are an effective technique for unsupervised discovery of interpretable features in language models' (LMs) activations, by finding sparse, linear reconstructions of LM activations. We…

Machine Learning · Computer Science 2024-05-01 Senthooran Rajamanoharan , Arthur Conmy , Lewis Smith , Tom Lieberum , Vikrant Varma , János Kramár , Rohin Shah , Neel Nanda

Sparse autoencoders (SAEs) have emerged as a powerful technique for extracting human-interpretable features from neural networks activations. Previous works compared different models based on SAE-derived features but those comparisons have…

Computer Vision and Pattern Recognition · Computer Science 2025-07-25 Clément Cornet , Romaric Besançon , Hervé Le Borgne

Sparse Autoencoders (SAEs) have proven to be powerful tools for interpreting neural networks by decomposing hidden representations into disentangled, interpretable features via sparsity constraints. However, conventional SAEs are…

Sparse autoencoders (SAEs) improve interpretability in multimodal models, but it remains unclear whether SAE features form modular, composable units for reasoning-an assumption underlying many intervention-based steering methods. We test…

Artificial Intelligence · Computer Science 2026-03-27 Yunpeng Zhou

Sparse autoencoders (SAEs) are a mechanistic interpretability technique that have been used to provide insight into learned concepts within large protein language models. Here, we employ TopK and Ordered SAEs to investigate autoregressive…

Artificial Text Detection (ATD) is becoming increasingly important with the rise of advanced Large Language Models (LLMs). Despite numerous efforts, no single algorithm performs consistently well across different types of unseen text or…

Sparse Autoencoders (SAEs) have emerged as a promising tool for interpreting neural networks by decomposing their activations into sparse sets of human-interpretable features. Recent work has introduced multiple SAE variants and…

Machine Learning · Computer Science 2026-02-17 Anton Korznikov , Andrey Galichin , Alexey Dontsov , Oleg Rogov , Ivan Oseledets , Elena Tutubalina

Sparse autoencoders (SAEs) have become a standard tool for mechanistic interpretability in autoregressive large language models (LLMs), enabling researchers to extract sparse, human-interpretable features and intervene on model behavior.…

Machine Learning · Computer Science 2026-02-06 Xu Wang , Bingqing Jiang , Yu Wan , Baosong Yang , Lingpeng Kong , Difan Zou

We present SAE-BrainMap, a novel framework that directly aligns deep learning visual model representations with voxel-level fMRI responses using sparse autoencoders (SAEs). First, we train layer-wise SAEs on model activations and compute…

Neurons and Cognition · Quantitative Biology 2025-06-16 Ziming Mao , Jia Xu , Zeqi Zheng , Haofang Zheng , Dabing Sheng , Yaochu Jin , Guoyuan Yang

A common goal of mechanistic interpretability is to decompose the activations of neural networks into features: interpretable properties of the input computed by the model. Sparse autoencoders (SAEs) are a popular method for finding these…

Machine Learning · Computer Science 2025-02-10 Patrick Leask , Bart Bussmann , Michael Pearce , Joseph Bloom , Curt Tigges , Noura Al Moubayed , Lee Sharkey , Neel Nanda

Sparse autoencoders (SAEs) have emerged as a powerful tool for interpreting large language models (LLMs) by decomposing token activations into combinations of human-understandable features. While SAEs provide crucial insights into LLM…

Machine Learning · Computer Science 2025-11-11 Zhen Xu , Zhen Tan , Song Wang , Kaidi Xu , Tianlong Chen

Large language models (LLMs) demonstrate exceptional performance on tasks requiring complex linguistic abilities, such as reference disambiguation and metaphor recognition/generation. Although LLMs possess impressive capabilities, their…

Computation and Language · Computer Science 2025-09-16 Yi Jing , Zijun Yao , Hongzhu Guo , Lingxu Ran , Xiaozhi Wang , Lei Hou , Juanzi Li

The evaluation of large language models (LLMs) relies heavily on standardized benchmarks. These benchmarks provide useful aggregated metrics for a given capability, but those aggregated metrics can obscure (i) particular sub-areas where the…

Computation and Language · Computer Science 2025-12-25 Matyas Bohacek , Nino Scherrer , Nicholas Dufour , Thomas Leung , Christoph Bregler , Stephanie C. Y. Chan