English
Related papers

Related papers: Drift-React: One-step Generation of Reaction Pathw…

200 papers

Estimating rate coefficients from complex chemical reactions is essential for advancing detailed chemistry. However, the stiffness inherent in real-world atmospheric chemistry systems poses severe challenges, leading to training instability…

Machine Learning · Computer Science 2025-09-01 Wenqing Peng , Zhi-Song Liu , Michael Boy

The high-temperature atom exchange and dissociation reaction dynamics of the O($^3$P) + O$_2(^3\Sigma_g^{-} )$ system are investigated based on a new reproducing kernel-based representation of high-level multi-reference configuration…

Chemical Physics · Physics 2025-06-09 JingChun Wang , Juan Carlos San Vicente Veliz , Meenu Upadhyay , Markus Meuwly

Drifting Models have emerged as a new paradigm for one-step generative modeling, achieving strong image quality without iterative inference. The premise is to replace the iterative denoising process in diffusion models with a single…

Machine Learning · Computer Science 2026-05-13 Ali Falahati , Elliot Creager , Gautam Kamath , Shubhankar Mohapatra

High-temperature reactions widely exist in nature. However, they are difficult to be characterized either experimentally or computationally. The routinely used minimum energy path (MEP) model in computational modeling of chemical reactions…

Chemical Physics · Physics 2020-05-13 Xiongzhi Zeng , Zongyang Qiu , Pai Li , Zhenyu Li , Jinlong Yang

Iterative generative models such as Flow Matching and Diffusion models have demonstrated strong test-time scaling behavior, where additional inference computation can improve generation quality. In contrast, Drift Models offer efficient…

Machine Learning · Computer Science 2026-05-19 Chenrui Ma , Xi Xiao , Lin Zhao , Tianyang Wang , Ferdinando Fioretto , Yanning Shen

Sampling molecular conformations from the Boltzmann distribution is essential for computational chemistry, but iterative diffusion methods are prohibitively slow. Drifting Models offer one-step generation, yet their equilibrium matches the…

Chemical Physics · Physics 2026-03-09 Pipi Hu

One of the most important and difficult parts of constructing a multidimensional numerical simulation of flame acceleration and deflagration-to-detonation transition (DDT) in a reacting flow is finding a reliable and affordable model of the…

Fluid Dynamics · Physics 2017-09-04 Carolyn R. Kaplan , Alp Ozgen , Elaine S. Oran

The differential cross sections of $pD\to ^3He X$ reactions, where $X=\eta, \ \eta'\ ,\omega, \ \phi $, are calculated on the basis of a two-step mechanism involving the subprocesses $pp\to d\pi ^+$ and $\pi^+n\to Xp $. It is shown that…

Nuclear Theory · Physics 2008-02-03 L. A. Kondratyuk , Yu. N. Uzikov

Transition states (TSs) are central to understanding and quantitatively predicting chemical reactivity and reaction mechanisms. Although traditional TS generation methods are computationally expensive, recent generative modeling approaches…

Chemical Physics · Physics 2026-02-12 Ron Shprints , Peter Holderrieth , Juno Nam , Rafael Gómez-Bombarelli , Tommi Jaakkola

We consider particle-based stochastic reaction-drift-diffusion models where particles move via diffusion and drift induced by one- and two-body potential interactions. The dynamics of the particles are formulated as measure-valued…

Probability · Mathematics 2025-01-22 Max Heldman , Samuel A. Isaacson , Qianhan Liu , Konstantinos Spiliopoulos

A new upscaling procedure that provides 1D representations of 2D mixing-limited reactive transport systems is developed and applied. A key complication with upscaled models in this setting is that the procedure must differentiate between…

Fluid Dynamics · Physics 2022-10-05 Ricardo H. Deucher , Louis J. Durlofsky

We discuss the ``soft-ratcheting'' algorithm which generates targeted stochastic trajectories in molecular systems with scores corresponding to their probabilities. The procedure, which requires no initial pathway guess, is capable of…

Chemical Physics · Physics 2007-05-23 Daniel M. Zuckerman , Thomas B. Woolf

Generative modeling can be formulated as learning a mapping f such that its pushforward distribution matches the data distribution. The pushforward behavior can be carried out iteratively at inference time, for example in diffusion and…

Machine Learning · Computer Science 2026-02-09 Mingyang Deng , He Li , Tianhong Li , Yilun Du , Kaiming He

Elucidating the catalytic descriptor that accurately characterizes the structure-activity relationships of typical catalysts for various important heterogeneous catalytic reactions is pivotal for designing high-efficient catalytic systems.…

Chemical Physics · Physics 2025-10-23 Zhen Zhu , Shan Gao , Jing Zhang , Xuxin Kang , Shunfang Li , Xiangmei Duan

A fundamental dilemma in generative modeling persists: iterative diffusion models achieve outstanding fidelity, but at a significant computational cost, while efficient few-step alternatives are constrained by a hard quality ceiling. This…

Machine Learning · Computer Science 2025-09-05 Zidong Wang , Yiyuan Zhang , Xiaoyu Yue , Xiangyu Yue , Yangguang Li , Wanli Ouyang , Lei Bai

Simulating chemical reactions is a central challenge in computational chemistry, characterized by an uneven difficulty profile: while equilibrium reactant and product geometries are often classically tractable, intermediate transition…

Although multi-step generative policies achieve strong performance in robotic manipulation by modeling multimodal action distributions, they require multi-step iterative denoising at inference time. Each action therefore needs tens to…

Robotics · Computer Science 2026-04-22 Yuxuan Gao , Yedong Shen , Shiqi Zhang , Wenhao Yu , Yifan Duan , Jia pan , Jiajia Wu , Jiajun Deng , Yanyong Zhang

In this paper mathematical models for the evolutionary conserved Notch-Delta pathway are developed and analyzed in order to better understand how two neighboring biological cells can become different. We pursue a structure-based…

Dynamical Systems · Mathematics 2026-04-08 Angela Stevens , Nicola Vassena

In the asymptotic limit of a large diffusivity ratio, certain two-component reaction-diffusion (RD) systems can admit localized spike solutions on a 1-D finite domain in a far-from-equilibrium nonlinear regime. It is known that two distinct…

Analysis of PDEs · Mathematics 2024-11-04 Chunyi Gai , Edgardo Villar-Sepulveda , Alan Champneys , Michael J. Ward

We construct path integrals for stochastic hybrid reaction-diffusion (RD) processes, in which the reaction terms depend on the discrete state of a randomly switching environment. We proceed by spatially discretizing a given RD system and…

Statistical Mechanics · Physics 2021-10-15 Paul C. Bressloff