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Large Language Models (LLMs) have demonstrated impressive capabilities across natural language processing tasks. However, their application to specialized domains such as medicine and biology requires further optimization to ensure factual…

Computation and Language · Computer Science 2025-02-06 Seonok Kim

Retrieval-Augmented Generation allows to enhance Large Language Models with external knowledge. In response to the recent popularity of generative LLMs, many RAG approaches have been proposed, which involve an intricate number of different…

Computation and Language · Computer Science 2024-07-02 David Rau , Hervé Déjean , Nadezhda Chirkova , Thibault Formal , Shuai Wang , Vassilina Nikoulina , Stéphane Clinchant

In this paper we introduce RE-tune, a novel approach for fine-tuning pre-trained Multimodal Biomedical Vision-Language models (VLMs) in Incremental Learning scenarios for multi-label chest disease diagnosis. RE-tune freezes the backbones…

Artificial Intelligence · Computer Science 2024-10-24 Marco Mistretta , Andrew D. Bagdanov

Entity linking is the task of linking mentions of named entities in natural language text, to entities in a curated knowledge-base. This is of significant importance in the biomedical domain, where it could be used to semantically annotate…

Computation and Language · Computer Science 2020-01-22 Ming Zhu , Busra Celikkaya , Parminder Bhatia , Chandan K. Reddy

It has long been recognized that it is not enough for a Recommender System (RS) to provide recommendations based only on their relevance to users. Among many other criteria, the set of recommendations may need to be diverse. Diversity is…

Information Retrieval · Computer Science 2024-06-19 Diego Carraro , Derek Bridge

Large language models (LLMs), with advanced linguistic capabilities, have been employed in reranking tasks through a sequence-to-sequence approach. In this paradigm, multiple passages are reranked in a listwise manner and a textual reranked…

Information Retrieval · Computer Science 2024-11-08 Ruiyang Ren , Yuhao Wang , Kun Zhou , Wayne Xin Zhao , Wenjie Wang , Jing Liu , Ji-Rong Wen , Tat-Seng Chua

We present ReMatch, a framework that leverages the generative strength of MLLMs for multimodal retrieval. Previous approaches treated an MLLM as a simple encoder, ignoring its generative nature, and under-utilising its compositional…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Qianying Liu , Xiao Liang , Zhiqiang Zhang , Zhongfei Qing , Fengfan Zhou , Yibo Chen , Xu Tang , Yao Hu , Paul Henderson

Recent advances in large language models (LLMs) and biomedical foundation models (BioFMs) have achieved strong results in biological text reasoning, molecular modeling, and single-cell analysis, yet they remain siloed in disjoint embedding…

Quantitative Methods · Quantitative Biology 2025-10-03 Ching-Huei Tsou , Michal Ozery-Flato , Ella Barkan , Diwakar Mahajan , Ben Shapira

Patient-trial matching requires reasoning over long, heterogeneous electronic health records (EHRs) and complex eligibility criteria, posing significant challenges for scalability, generalization, and computational efficiency. Existing…

Computation and Language · Computer Science 2026-04-27 Xiaodi Li , Yang Xiao , Munhwan Lee , Konstantinos Leventakos , Young J. Juhn , David Jones , Terence T. Sio , Wei Liu , Maria Vassilaki , Nansu Zong

Recent studies increasingly explore Large Language Models (LLMs) as a new paradigm for recommendation systems due to their scalability and world knowledge. However, existing work has three key limitations: (1) most efforts focus on…

Machine learning (ML) holds great promise for clinical applications but is often hindered by limited access to high-quality data due to privacy concerns, high costs, and long timelines associated with clinical trials. While large language…

Computation and Language · Computer Science 2026-03-27 Zerui Xu , Fang Wu , Yingzhou Lu , Yuanyuan Zhang , Yue Zhao

Generative approaches have been recently shown to be effective for both Entity Disambiguation and Entity Linking (i.e., joint mention detection and disambiguation). However, the previously proposed autoregressive formulation for EL suffers…

Computation and Language · Computer Science 2021-09-09 Nicola De Cao , Wilker Aziz , Ivan Titov

Biomedical named entity recognition (NER) is a fundamental task in text mining of medical documents and has many applications. Deep learning based approaches to this task have been gaining increasing attention in recent years as their…

Computation and Language · Computer Science 2018-08-16 Devendra Singh Sachan , Pengtao Xie , Mrinmaya Sachan , Eric P Xing

Our team participated in the BioASQ 2024 Task12b and Synergy tasks to build a system that can answer biomedical questions by retrieving relevant articles and snippets from the PubMed database and generating exact and ideal answers. We…

Computation and Language · Computer Science 2024-07-10 Wenxin Zhou , Thuy Hang Ngo

Evidence-based medicine (EBM) holds a crucial role in clinical application. Given suitable medical articles, doctors effectively reduce the incidence of misdiagnoses. Researchers find it efficient to use large language models (LLMs)…

Computation and Language · Computer Science 2025-11-07 Mengzhou Sun , Sendong Zhao , Jianyu Chen , Haochun Wang , Bing Qin

The proliferation of open-sourced Large Language Models (LLMs) and diverse downstream tasks necessitates efficient model selection, given the impracticality of fine-tuning all candidates due to computational constraints. Despite the recent…

Machine Learning · Computer Science 2025-06-03 Xinyue Zeng , Haohui Wang , Junhong Lin , Jun Wu , Tyler Cody , Dawei Zhou

Agentic Retrieval Augmented Generation (RAG) and 'deep research' systems aim to enable autonomous search processes where Large Language Models (LLMs) iteratively refine outputs. However, applying these systems to domain-specific…

Computation and Language · Computer Science 2025-08-08 Samy Ateia , Udo Kruschwitz

Fine-tuning on task-specific data to boost downstream performance is a crucial step for leveraging Large Language Models (LLMs). However, previous studies have demonstrated that fine-tuning the models on several adversarial samples or even…

Machine Learning · Computer Science 2024-10-14 Han Shen , Pin-Yu Chen , Payel Das , Tianyi Chen

Large language models (LLMs) have demonstrated dominating performance in many NLP tasks, especially on generative tasks. However, they often fall short in some information extraction tasks, particularly those requiring domain-specific…

Computation and Language · Computer Science 2023-09-22 Junyi Bian , Jiaxuan Zheng , Yuyi Zhang , Shanfeng Zhu

Due to large number of entities in biomedical knowledge bases, only a small fraction of entities have corresponding labelled training data. This necessitates entity linking models which are able to link mentions of unseen entities using…

Computation and Language · Computer Science 2021-04-12 Rico Angell , Nicholas Monath , Sunil Mohan , Nishant Yadav , Andrew McCallum