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We present superconducting nanowire single-photon detectors (SNSPDs) based on few-layer NbSe$_2$ fully encapsulated with hexagonal boron nitride (hBN), demonstrating single-photon sensitivity. Our fabrication process preserves the…

Despite recent progress in nonlinear optics in wavelength-scale resonators, there are still open questions on the possibility of parametric oscillation in such resonators. We present a general approach to predict the behavior and estimate…

Optics · Physics 2021-02-22 Saman Jahani , Arkadev Roy , Alireza Marandi

We investigate the translocation of a single stranded DNA (ssDNA) through a pore, which fluctuates between two conformations, by using coupled master equations (ME). The probability density function (PDF) of the first passage times (FPT) of…

Subcellular Processes · Quantitative Biology 2007-05-23 O. Flomenbom , J. Klafter

Scalable, high speed data transfer between cryogenic (0.1-4 K) and room temperature environments is instrumental in a broad range of fields including quantum computing, superconducting electronics, single photon imaging and space-based…

Applied Physics · Physics 2020-02-04 Marc de Cea , Emma E. Wollman , Amir H. Atabaki , Dodd J. Gray , Matthew D. Shaw , Rajeev J. Ram

Intravascular polarimetry with catheter-based polarization-sensitive optical coherence tomography (PS-OCT) complements the high-resolution structural tomograms of OCT with morphological contrast available through polarimetry. Its clinical…

Adequate read filtering is critical when processing high-throughput data in marker-gene-based studies. Sequencing errors can cause the mis-clustering of otherwise similar reads, artificially increasing the number of retrieved Operational…

Quantitative Methods · Quantitative Biology 2015-06-02 Fernando Puente-Sánchez , Jacobo Aguirre , Víctor Parro

Characterizing conformational transitions in physical systems remains a fundamental challenge, as traditional sampling methods struggle with the high-dimensional nature of molecular systems and high-energy barriers between stable states.…

Chemical Physics · Physics 2025-09-22 Magnus Petersen , Gemma Roig , Roberto Covino

A new general route for siRNA delivery is presented combining porous core-shell silica nanocarriers with a modularly designed multifunctional block copolymer. Specifically, the internal storage and release of siRNA from mesoporous silica…

Subcellular Processes · Quantitative Biology 2016-03-23 Karin Moeller , Katharina Mueller , Hanna Engelke , Christoph Braeuchle , Ernst Wagner , Thomas Bein

In the framework of convolutional neural networks that lie at the heart of deep learning, downsampling is often performed with a max-pooling operation that only retains the element with maximum activation, while completely discarding the…

Computer Vision and Pattern Recognition · Computer Science 2018-04-17 Ashwani Kumar

Finding an approximate second-order stationary point (SOSP) is a well-studied and fundamental problem in stochastic nonconvex optimization with many applications in machine learning. However, this problem is poorly understood in the…

Optimization and Control · Mathematics 2024-03-19 Shuyao Li , Yu Cheng , Ilias Diakonikolas , Jelena Diakonikolas , Rong Ge , Stephen J. Wright

Solid-state nanopore and nanopipette sensors are powerful devices for the detection, quantification and structural analysis of biopolymers such as DNA and proteins, especially in carrier-enhanced resistive-pulse sensing. However, hundreds…

Mesoscale and Nanoscale Physics · Physics 2025-10-14 Cengiz J. Khan , Oliver J. Irving , Rand A. Al-Waqfi , Giorgio Ferrari , Tim Albrecht

Surface characterizations of an organophosphorus (OP) gas detector based on chemically functionalized silicon nanoribbon field-effect transistor (SiNR-FET) were performed by Kelvin Probe Force Microscopy (KPFM) and ToF-SIMS, and correlated…

Mesoscale and Nanoscale Physics · Physics 2016-06-16 K. Smaali , D. Guerin , V. Passi , L. Ordronneau , A. Carella , T. Melin , E. Dubois , D. Vuillaume , J. P. Simonato , S. Lenfant

Omnidirectional images (ODIs) have obtained lots of research interest for immersive experiences. Although ODIs require extremely high resolution to capture details of the entire scene, the resolutions of most ODIs are insufficient. Previous…

Image and Video Processing · Electrical Eng. & Systems 2023-02-10 Fanghua Yu , Xintao Wang , Mingdeng Cao , Gen Li , Ying Shan , Chao Dong

Quantitative imaging of subcellular processes in living embryos, stem-cell systems, and organoid models requires microscopy platforms that combine high spatial resolution, fast volumetric acquisition, long-term stability, and minimal…

Quantitative Methods · Quantitative Biology 2025-12-30 Armin Shoushtarizadeh , Michele Cerminara , Corinne Chureau , Leah Friedman , Deepthi Kailash , Thomas Gregor

State-of-the-art optical wireless positioning (OWP) commonly reaches centimeter-level accuracy by depending on dense multi-light-emitting diodes (LED) infrastructures, photodiode (PD) arrays, or image-sensor receivers, incurring hardware…

Nanofabrication techniques for achieving dimensional control at the nanometer scale are generally equipment-intensive and time-consuming. The use of energetic beams of electrons or ions has placed the fabrication of nanopores in thin…

Mesoscale and Nanoscale Physics · Physics 2014-03-25 Harold Kwok , Kyle Briggs , Vincent Tabard-Cossa

The negatively-charged nitrogen-vacancy center (NV) in diamond forms a versatile system for quantum sensing applications. Combining the advantageous properties of this atomic-sized defect with scanning probe techniques such as atomic force…

Mesoscale and Nanoscale Physics · Physics 2018-12-26 Philipp Fuchs , Michel Challier , Elke Neu

Coherent optics has demonstrated significant potential as a viable solution for achieving 100 Gb/s and higher speeds in single-wavelength passive optical networks (PON). However, upstream burst-mode coherent detection is a major challenge…

Signal Processing · Electrical Eng. & Systems 2024-09-24 Yongxin Sun , Hexun Jiang , Yicheng Xu , Mengfan Fu , Yixiao Zhu , Lilin Yi , Weisheng Hu , Qunbi Zhuge

Fluorescence imaging allows for non-invasively visualizing and measuring key physiological parameters like pH and dissolved oxygen. In our work, we created two ratiometric fluorescent microsensors designed for accurately tracking dissolved…

Snapshot compressive imaging (SCI) captures multispectral images (MSIs) using a single coded two-dimensional (2-D) measurement, but reconstructing high-fidelity MSIs from these compressed inputs remains a fundamentally ill-posed challenge.…

Image and Video Processing · Electrical Eng. & Systems 2025-12-02 Shaoguang Huang , Yunzhen Wang , Haijin Zeng , Hongyu Chen , Hongyan Zhang