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In microbiome and genomic studies, the regression of compositional data has been a crucial tool for identifying microbial taxa or genes that are associated with clinical phenotypes. To account for the variation in sequencing depth, the…

Methodology · Statistics 2021-03-11 Pixu Shi , Yuchen Zhou , Anru R. Zhang

Methods of deep learning have become increasingly popular in recent years, but they have not arrived in compositional data analysis. Imputation methods for compositional data are typically applied on additive, centered or isometric…

Machine Learning · Statistics 2020-12-21 Matthias Templ

Identifying which taxa in our microbiota are associated with traits of interest is important for advancing science and health. However, the identification is challenging because the measured vector of taxa counts (by amplicon sequencing) is…

Genomics · Quantitative Biology 2020-03-31 Barak Brill , Amnon Amir , Ruth Heller

The Dirichlet-multinomial (DM) distribution plays a fundamental role in modern statistical methodology development and application. Recently, the DM distribution and its variants have been used extensively to model multivariate count data…

Methodology · Statistics 2023-02-27 Matthew D. Koslovsky

This paper is motivated by the recent interest in the analysis of high dimen- sional microbiome data. A key feature of this data is the presence of `structural zeros' which are microbes missing from an observation vector due to an…

Applications · Statistics 2016-05-23 Abhishek Kaul , Ori Davidov , Shyamal D. Peddada

Motivated by the challenges in analyzing gut microbiome and metagenomic data, this work aims to tackle the issue of measurement errors in high-dimensional regression models that involve compositional covariates. This paper marks a…

Methodology · Statistics 2024-09-13 Huali Zhao , Tianying Wang

High-dimensional compositional data arise naturally in many applications such as metagenomic data analysis. The observed data lie in a high-dimensional simplex, and conventional statistical methods often fail to produce sensible results due…

Methodology · Statistics 2016-01-19 Yuanpei Cao , Wei Lin , Hongzhe Li

Compositional data are met in many different fields, such as economics, archaeometry, ecology, geology and political sciences. Regression where the dependent variable is a composition is usually carried out via a log-ratio transformation of…

Methodology · Statistics 2017-06-08 Michail Tsagris , Connie Stewart

In real world applications dealing with compositional datasets, it is easy to face the presence of structural zeros. The latter arise when, due to physical limitations, one or more variables are intrinsically zero for a subset of the…

Methodology · Statistics 2025-10-28 Francesco Porro , Fabio Rapallo , Sara Sommariva

We introduce a novel approach to compositional data analysis based on $L^{\infty}$-normalization, addressing challenges posed by zero-rich high-throughput data. Traditional methods like Aitchison's transformations require excluding zeros,…

Computation · Statistics 2025-03-28 Pawel Gajer , Jacques Ravel

Collecting robotic manipulation data is expensive, making it impractical to acquire demonstrations for the combinatorially large space of tasks that arise in multi-object, multi-robot, and multi-environment settings. While recent generative…

Every Model of High-Level Computation (MHC) has an underlying composition mechanism for combining simple computing devices into more complex ones. Composition can be done by (explicitly or implicitly) defining control flow, data flow or any…

Logic in Computer Science · Computer Science 2026-05-22 Damian Arellanes

This paper introduces a rectified and renormalized Fisher-Bingham model for compositional data with zeros, motivated in part by the presence of zeros in microbiota studies. The approach represents compositions through a square-root…

Methodology · Statistics 2026-04-29 Eugene Han , Marahi Perez-Tamayo , Hannah D. Holscher , Ruoqing Zhu

Changes in land use patterns have significant environmental and socioeconomic impacts, making it crucial for policymakers to understand their causes and consequences. This study, part of the European LAMASUS (Land Management for…

Missing data is a fundamental challenge in data science, significantly hindering analysis and decision-making across a wide range of disciplines, including healthcare, bioinformatics, social science, e-commerce, and industrial monitoring.…

Machine Learning · Statistics 2026-05-12 Jicong Fan

Compositional data sets are ubiquitous in science, including geology, ecology, and microbiology. In microbiome research, compositional data primarily arise from high-throughput sequence-based profiling experiments. These data comprise…

Statistics Theory · Mathematics 2019-03-05 Patrick L. Combettes , Christian L. Müller

Compositional data and multivariate count data with known totals are challenging to analyse due to the non-negativity and sum-to-one constraints on the sample space. It is often the case that many of the compositional components are highly…

Methodology · Statistics 2020-12-24 Janice L. Scealy , Andrew T. A. Wood

In many cases, a machine learning model must learn to correctly predict a few data points with particular values of interest in a broader range of data where many target values are zero. Zero-inflated data can be found in diverse scenarios,…

A frequent challenge encountered with compositional ecological data is how to interpret and model data with a high proportion of zeros and $N$'s. Such data frequently occur in ecological applications where counts of species are collected…

Methodology · Statistics 2025-08-04 James Sweeney , John Haslett , Dipankar Bandyopadhyay , Michael Fop , Andrew C. Parnell

Biological sequencing data consist of read counts, e.g. of specified taxa and often exhibit sparsity (zero-count inflation) and overdispersion (extra-Poisson variability). As most sequencing techniques provide an arbitrary total count,…

Applications · Statistics 2024-07-01 Noora Kartiosuo , Jaakko Nevalainen , Olli Raitakari , Katja Pahkala , Kari Auranen
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