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Biomedical retrieval-augmented generation (RAG) can ground LLM answers in medical literature, yet long-form outputs often contain isolated unsupported or contradictory claims with safety implications. We introduce MedRAGChecker, a…

Computation and Language · Computer Science 2026-01-13 Yuelyu Ji , Min Gu Kwak , Hang Zhang , Xizhi Wu , Chenyu Li , Yanshan Wang

Retrieval-augmented generation (RAG) grounds answers in retrieved passages, but retrieval is not verification: a passage can be topical and still fail to justify the answer. We frame this gap as evidence sufficiency verification for…

Computation and Language · Computer Science 2026-05-06 Jingxi Qiu , Zeyu Han , Cheng Huang

Current Retrieval-Augmented Generation (RAG) systems predominantly rely on relevance-based dense retrieval, sequentially fetching documents to maximize semantic similarity with the query. However, in knowledge-intensive and real-world…

Artificial Intelligence · Computer Science 2026-03-31 Davide Di Gioia

Biomedical question answering (QA) requires accurate interpretation of complex medical knowledge. Large language models (LLMs) have shown promising capabilities in this domain, with retrieval-augmented generation (RAG) systems enhancing…

Computation and Language · Computer Science 2025-10-21 Yingpeng Ning , Yuanyuan Sun , Ling Luo , Yanhua Wang , Yuchen Pan , Hongfei Lin

Deployed language models must decide not only what to answer but also when not to answer. We present UniCR, a unified framework that turns heterogeneous uncertainty evidence including sequence likelihoods, self-consistency dispersion,…

Computation and Language · Computer Science 2025-12-30 Markus Oehri , Giulia Conti , Kaviraj Pather , Alexandre Rossi , Laia Serra , Adrian Parody , Rogvi Johannesen , Aviaja Petersen , Arben Krasniqi

Automated question-answering (QA) systems increasingly rely on retrieval-augmented generation (RAG) to ground large language models (LLMs) in authoritative medical knowledge, ensuring clinical accuracy and patient safety in Artificial…

Computation and Language · Computer Science 2026-03-05 Aswini Sivakumar , Vijayan Sugumaran , Yao Qiang

Although precise recall is a core objective in Retrieval-Augmented Generation (RAG), a critical oversight persists in the field: improvements in retrieval performance do not consistently translate to commensurate gains in downstream…

Information Retrieval · Computer Science 2026-05-01 Shiyao Peng , Qianhe Zheng , Zhuodi Hao , Zichen Tang , Rongjin Li , Qing Huang , Jiayu Huang , Jiacheng Liu , Yifan Zhu , Haihong E

Complex scientific questions often entail multiple intents, such as identifying gene mutations and linking them to related diseases. These tasks require evidence from diverse sources and multi-hop reasoning, while conventional…

Artificial Intelligence · Computer Science 2025-11-21 Zhiyuan Li , Haisheng Yu , Guangchuan Guo , Nan Zhou , Jiajun Zhang

Retrieval-augmented generation (RAG) grounds large language models in external medical knowledge, yet standard retrievers frequently surface hard negatives that are semantically close to the query but describe clinically distinct…

Information Retrieval · Computer Science 2026-04-07 Byeolhee Kim , Min-Kyung Kim , Young-Hak Kim , Tae-Joon Jeon

Selective Classification, wherein models can reject low-confidence predictions, promises reliable translation of machine-learning based classification systems to real-world scenarios such as clinical diagnostics. While current evaluation of…

The selection of appropriate medical imaging procedures is a critical and complex clinical decision, guided by extensive evidence-based standards such as the ACR Appropriateness Criteria (ACR-AC). However, the underutilization of these…

Quantitative Methods · Quantitative Biology 2025-10-07 Satrio Pambudi , Filippo Menolascina

Existing research on Retrieval-Augmented Generation (RAG) primarily focuses on improving overall question-answering accuracy, often overlooking the quality of sub-claims within generated responses. Recent methods that attempt to improve RAG…

Information Retrieval · Computer Science 2025-06-27 Naihe Feng , Yi Sui , Shiyi Hou , Jesse C. Cresswell , Ga Wu

Discharge summaries require extracting critical information from lengthy electronic health records (EHRs), a process that is labor-intensive when performed manually. Large language models (LLMs) can improve generation efficiency; however,…

Computation and Language · Computer Science 2026-05-06 Severin Ye , Xiao Kong , Xiaopeng He , Guangsu Yan , Dongsuk Oh

Retrieval-augmented generation (RAG) is susceptible to retrieval corruption attacks, where malicious passages injected into retrieval results can lead to inaccurate model responses. We propose RobustRAG, the first defense framework with…

Machine Learning · Computer Science 2026-04-02 Chong Xiang , Tong Wu , Zexuan Zhong , David Wagner , Danqi Chen , Prateek Mittal

As language models shift from single-shot answer generation toward multi-step reasoning that retrieves and consumes evidence mid-inference, evaluating the role of individual retrieved items becomes more important. Existing RAG evaluation…

Information Retrieval · Computer Science 2026-04-08 Siddharth Jain , Venkat Narayan Vedam

Large language models (LLMs) can enhance factuality via retrieval-augmented generation (RAG), but applying RAG to every query is unnecessary when the model-only answer is reliable. This motivates cascaded RAG: each query is first handled by…

Computation and Language · Computer Science 2026-05-20 Zijun Jia , Yuanchang Ye , Sen Jia , Yiyao Qian , Haoning Wang , Baojie Chen , Diyin Tang , Jinsong Yu , Zhiyuan Wang

Retrieval-augmented generation (RAG) improves large language models (LLMs) by incorporating external evidence, but it also introduces knowledge conflicts when retrieved contextual knowledge (CK) and parametric knowledge (PK) disagree or are…

Information Retrieval · Computer Science 2026-05-20 Xi Zhu , Ziqi Wang , Kai Mei , Wujiang Xu , Minghao Guo , Bangji Yang , Jiajun Fan , Dimitris N. Metaxas

The positive-unlabeled (PU) classification is a common scenario in real-world applications such as healthcare, text classification, and bioinformatics, in which we only observe a few samples labeled as "positive" together with a large…

Machine Learning · Computer Science 2018-03-20 Ke Ren , Haichuan Yang , Yu Zhao , Mingshan Xue , Hongyu Miao , Shuai Huang , Ji Liu

Obtaining accurate class labels is often costly or unreliable, and may also be limited by privacy or other practical conditions. Compared with asking an annotator to provide the exact class, it is often easier to ask whether the true label…

Machine Learning · Computer Science 2026-05-11 Jiaxu Su , Junpeng Li , Changchun Hua , Yana Yang

Biomedical question-answering (QA) systems require effective retrieval and generation components to ensure accuracy, efficiency, and scalability. This study systematically examines a Retrieval-Augmented Generation (RAG) system for…

Information Retrieval · Computer Science 2026-01-14 Linus Stuhlmann , Michael Alexander Saxer , Jonathan Fürst
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