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Women are underdiagnosed and undertreated for cardiovascular disease. Automatic quantification of breast arterial calcification on screening mammography can identify women at risk for cardiovascular disease and enable earlier treatment and…

Hypertrophic cardiomyopathy (HCM) requires accurate risk stratification to inform decisions regarding ICD therapy and follow-up management. Current established models, such as the European Society of Cardiology (ESC) score, exhibit moderate…

We assessed the benefit of combining stress cardiac CT perfusion (CCTP) myocardial blood flow (MBF) with coronary CT angiography (CCTA) using our innovative CCTP software. By combining CCTA and CCTP, one can uniquely identify a flow…

Coronary artery calcium (CAC) is biomarker of advanced subclinical coronary artery disease and predicts myocardial infarction and death prior to age 60 years. The slice-wise manual delineation has been regarded as the gold standard of…

Computer Vision and Pattern Recognition · Computer Science 2018-11-13 Yuankai Huo , James G. Terry , Jiachen Wang , Vishwesh Nath , Camilo Bermudez , Shunxing Bao , Prasanna Parvathaneni , J. Jeffery Carr , Bennett A. Landman

Heavy smokers undergoing screening with low-dose chest CT are affected by cardiovascular disease as much as by lung cancer. Low-dose chest CT scans acquired in screening enable quantification of atherosclerotic calcifications and thus…

Computer Vision and Pattern Recognition · Computer Science 2018-02-06 Nikolas Lessmann , Bram van Ginneken , Majd Zreik , Pim A. de Jong , Bob D. de Vos , Max A. Viergever , Ivana Išgum

We analyze the Agatston score of coronary artery calcium (CAC) from the Multi-Ethnic Study of Atherosclerosis (MESA) using the semiparametric zero-inflated modeling approach, where the observed CAC scores from this cohort consist of high…

Applications · Statistics 2012-10-02 Hai Liu , Shuangge Ma , Richard Kronmal , Kung-Sik Chan

Cardiovascular disease remains a leading cause of mortality in the contemporary world. Its association with smoking, elevated blood pressure, and cholesterol levels underscores the significance of these risk factors. This study addresses…

Machine Learning · Computer Science 2023-11-02 Jonayet Miah , Duc M Ca , Md Abu Sayed , Ehsanur Rashid Lipu , Fuad Mahmud , S M Yasir Arafat

Coronary artery calcium (CAC) burden quantified in low-dose chest CT is a predictor of cardiovascular events. We propose an automatic method for CAC quantification, circumventing intermediate segmentation of CAC. The method determines a…

Computer Vision and Pattern Recognition · Computer Science 2017-12-11 Bob D. de Vos , Nikolas Lessmann , Pim A. de Jong , Max A. Viergever , Ivana Isgum

We propose a fully automated algorithm based on a deep learning framework enabling screening of a coronary computed tomography angiography (CCTA) examination for confident detection of the presence or absence of coronary artery…

Image and Video Processing · Electrical Eng. & Systems 2020-06-09 Sema Candemir , Richard D. White , Mutlu Demirer , Vikash Gupta , Matthew T. Bigelow , Luciano M. Prevedello , Barbaros S. Erdal

In medical science, it is very important to gather multiple data on different diseases and one of the most important objectives of the data is to investigate the diseases. Myocardial infarction is a serious risk factor in mortality and in…

Machine Learning · Computer Science 2021-12-16 Tanya Aghazadeh , Mostafa Bagheri

Coronary artery calcium (CAC) scoring from chest CT is a well-established tool to stratify and refine clinical cardiovascular disease risk estimation. CAC quantification relies on the accurate delineation of calcified lesions, but is…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Xinran Gong , Gorkem Durak , Halil Ertugrul Aktas , Vedat Cicek , Jinkui Hao , Ulas Bagci , Nilay S. Shah , Bo Zhou

This case study details The University of Texas Medical Branch (UTMB)'s partnership with Zauron Labs, Inc. to enhance detection and coding of aortic calcifications (ACs) using chest radiographs. ACs are often underreported despite their…

Image and Video Processing · Electrical Eng. & Systems 2025-09-30 Eric Walser , Peter McCaffrey , Kal Clark , Nicholas Czarnek

Coronary artery calcification (CAC) is a strong predictor of cardiovascular risk but remains underutilized in clinical routine thoracic imaging due to the need for dedicated imaging protocols and manual annotation. We present DeepCAC2, a…

Image and Video Processing · Electrical Eng. & Systems 2026-03-27 Leonard Nürnberg , Simon Bernatz , Borek Foldyna , Michael T. Lu , Andrey Fedorov , Hugo JWL Aerts

Ensuring timely and accurate diagnosis of medical conditions is paramount for effective patient care. Electrocardiogram (ECG) signals are fundamental for evaluating a patient's cardiac health and are readily available. Despite this, little…

Signal Processing · Electrical Eng. & Systems 2025-11-21 Juan Miguel Lopez Alcaraz , Nils Strodthoff

Objective: We aim to provide an algorithm for the detection of myocardial infarction that operates directly on ECG data without any preprocessing and to investigate its decision criteria. Approach: We train an ensemble of fully…

Computers and Society · Computer Science 2019-02-06 Nils Strodthoff , Claas Strodthoff

Background: Extensive clinical evidence suggests that a preventive screening of coronary heart disease (CHD) at an earlier stage can greatly reduce the mortality rate. We use 64 two-dimensional speckle tracking echocardiography (2D-STE)…

Machine Learning · Statistics 2021-05-21 Jingyi Zhang , Huolan Zhu , Yongkai Chen , Chenguang Yang , Huimin Cheng , Yi Li , Wenxuan Zhong , Fang Wang

Clinical risk stratification for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HC) employs rules derived from American College of Cardiology Foundation/American Heart Association (ACCF/AHA) guidelines or the HCM Risk-SCD model…

Cardiovascular stability estimation from wearable photoplethysmography (PPG) requires a principled nonlinear framework, yet major gaps persist in heuristic parameter selection and evaluation protocols that inflate reported performance. We…

Signal Processing · Electrical Eng. & Systems 2026-05-20 Timothy Oladunni , Farouk Ganiyu Adewumi

Cardiovascular disease (CVD) is the global leading cause of death. A strong risk factor for CVD events is the amount of coronary artery calcium (CAC). To meet demands of the increasing interest in quantification of CAC, i.e. coronary…

Computer Vision and Pattern Recognition · Computer Science 2021-09-09 Bob D. de Vos , Jelmer M. Wolterink , Tim Leiner , Pim A. de Jong , Nikolas Lessmann , Ivana Isgum

Background: Invasive coronary arteriography (ICA) is recognized as the gold standard for diagnosing cardiovascular diseases, including unstable angina (UA). The challenge lies in determining the optimal timing for ICA in UA patients,…

Machine Learning · Computer Science 2024-08-09 Candi Zheng , Kun Liu , Yang Wang , Shiyi Chen , Hongli Li