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Agentic AI has significantly extended the capabilities of large language models (LLMs) by enabling complex reasoning and tool use. However, most existing frameworks are tailored to domains such as mathematics, coding, or web automation, and…

Artificial Intelligence · Computer Science 2025-10-15 Md Hasebul Hasan , Mahir Labib Dihan , Tanzima Hashem , Mohammed Eunus Ali , Md Rizwan Parvez

Mixture-of-Agents (MoA) inference can suffer from dense inter-agent communication and low hardware utilization, which jointly inflate serving latency. We present a serving design that targets these bottlenecks through an algorithm-system…

Artificial Intelligence · Computer Science 2025-12-23 Zijun Wang , Yijiahao Qi , Hanqiu Chen , Zishen Wan , Gongjin Sun , Dongyang Li , Shuyi Pei , Cong Hao

Most AI systems today are designed to manage tasks and execute predefined steps. This makes them effective for process coordination but limited in their ability to engage in joint problem-solving with humans or contribute new ideas. We…

Human-Computer Interaction · Computer Science 2026-02-03 Kexin Quan , Dina Albassam , Mengke Wu , Zijian Ding , Jessie Chin

We present the first implementation of AI agents into the design and optimization of detectors in high-energy physics experiments via a bilevel optimization framework that vertically integrates detector geometry, front-end digitization, and…

Instrumentation and Detectors · Physics 2026-04-24 Wonyong Chung , Qibin Liu , Liangyu Wu , Julia Gonski

The rapid advancement of artificial intelligence, particularly autonomous agentic systems based on Large Language Models (LLMs), presents new opportunities to accelerate drug discovery by improving in-silico modeling and reducing dependence…

AI for supporting designers needs to be rethought. It should aim to cooperate, not automate, by supporting and leveraging the creativity and problem-solving of designers. The challenge for such AI is how to infer designers' goals and then…

Human-Computer Interaction · Computer Science 2021-07-29 Sebastiaan De Peuter , Antti Oulasvirta , Samuel Kaski

System Instructions (SIs), or system prompts, are pivotal for guiding Large Language Models (LLMs) but manual crafting is resource-intensive and often suboptimal. Existing automated methods frequently generate non-human-readable "soft…

Artificial Intelligence · Computer Science 2025-07-08 Jeshwanth Challagundla

In this preprint, we present A collaborative human-AI approach to building an inspectable semantic layer for Agentic AI. AI agents first propose candidate knowledge structures from diverse data sources; domain experts then validate,…

Artificial Intelligence · Computer Science 2025-12-05 Liam McGee , James Harvey , Lucy Cull , Andreas Vermeulen , Bart-Floris Visscher , Malvika Sharan

As large language models are increasingly deployed as interacting agents in high-stakes decisions, the AI safety community assumes that safety properties of individual models will compose into safe multi-agent behavior. This position paper…

Artificial Intelligence · Computer Science 2026-05-05 Tanav Singh Bajaj , Nikhil Singh , Karan Anand , Eishkaran Singh

Automating science laboratories enables faster, safer, more accurate, and more reproducible execution of protocols, accelerating the discovery and testing of new materials, drugs, and more. However, setting up and running autonomous labs…

Artificial Intelligence · Computer Science 2026-05-19 Angelos Angelopoulos , James F. Cahoon , Ron Alterovitz

This paper introduces a novel Large Language Models (LLMs)-assisted agent that automatically converts natural-language descriptions of power system optimization scenarios into compact, solver-ready formulations and generates corresponding…

Artificial Intelligence · Computer Science 2025-08-12 Yunkai Hu , Tianqiao Zhao , Meng Yue

Large language model (LLM)-based agents are increasingly used to perform complex, multi-step workflows in regulated settings such as compliance and due diligence. However, many agentic architectures rely primarily on prompt engineering of a…

Artificial Intelligence · Computer Science 2026-02-03 Ananya Joshi , Michael Rudow

Automatically generating formal ontologies from unstructured natural language remains a central challenge in knowledge engineering. While large language models (LLMs) show promise, it remains unclear which architectural design choices drive…

Artificial Intelligence · Computer Science 2026-04-28 Abid Talukder , Maruf Ahmed Mridul , Oshani Seneviratne

In this work we explore the performance and behavior of reasoning large language models to autonomously optimize atomic layer deposition (ALD) processes. In the ALD process optimization task, an agent built on top of a reasoning LLM has to…

Materials Science · Physics 2026-01-16 Angel Yanguas-Gil

Designing and optimizing multi-agent systems (MAS) is a complex, labor-intensive process of "Agent Engineering." Existing automatic optimization methods, primarily focused on flat prompt tuning, lack the structural awareness to debug the…

Artificial Intelligence · Computer Science 2026-04-23 Shan He , Runze Wang , Zhuoyun Du , Huiyu Bai , Zouying Cao , Yu Cheng , Bo Zheng

AI governance programmes increasingly rely on natural language prompts to constrain and direct AI agent behaviour. These prompts function as executable specifications: they define the agent's mandate, scope, and quality criteria. Despite…

Software Engineering · Computer Science 2026-04-24 Christo Zietsman

Robust topology optimization (RTO), as a class of topology optimization problems, identifies a design with the best average performance while reducing the response sensitivity to input uncertainties, e.g. load uncertainty. Solving RTO is…

Machine Learning · Computer Science 2024-08-22 Rini Jasmine Gladstone , Mohammad Amin Nabian , Vahid Keshavarzzadeh , Hadi Meidani

Large language models (LLMs) are being widely applied across various fields, but as tasks become more complex, evaluating their responses is increasingly challenging. Compared to human evaluators, the use of LLMs to support performance…

Artificial Intelligence · Computer Science 2025-04-25 Yuran Li , Jama Hussein Mohamud , Chongren Sun , Di Wu , Benoit Boulet

Developing AI models that are useful in clinical practice, requires efficient collaboration between clinicians and AI developers. This poses a practical challenge: clinicians must repeatedly communicate and refine their requirements with AI…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Zihao Zhao , Frederik Hauke , Juliana De Castilhos , Mathis Bode , Jakob Nikolas Kather , Sven Nebelung , Daniel Truhn

User prompts for generative AI models are often underspecified, leading to a misalignment between the user intent and models' understanding. As a result, users commonly have to painstakingly refine their prompts. We study this alignment…

Artificial Intelligence · Computer Science 2025-10-27 Meera Hahn , Wenjun Zeng , Nithish Kannen , Rich Galt , Kartikeya Badola , Been Kim , Zi Wang