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Drug discovery frequently loses momentum when data, expertise, and tools are scattered, slowing design cycles. To shorten this loop we built a hierarchical, tool using agent framework that automates molecular optimisation. A Principal…

Machine Learning · Computer Science 2025-08-06 Atabey Ünlü , Phil Rohr , Ahmet Celebi

Recently, Agentic AI has become an increasingly popular research field. However, we argue that current agent research practices lack standardization and scientific rigor, making it hard to conduct fair comparisons among methods. As a…

Topological materials occupy a frontier in condensed-matter physics thanks to their remarkable electronic and quantum properties, yet their cross-scale design remains bottlenecked by inefficient discovery workflows. Here, we introduce…

Materials Science · Physics 2025-07-08 Baohua Zhang , Xin Li , Huangchao Xu , Zhong Jin , Quansheng Wu , Ce Li

Automating scientific computing workflows requires more than generating executable code: autonomous systems must also select appropriate computational strategies, implement them faithfully, and ensure that the resulting outcomes remain…

Artificial Intelligence · Computer Science 2026-05-29 Geremy Loachamín-Suntaxi , Robert Lazar , Dimitrios G. Giovanis , Ioannis G. Kevrekidis , Eleni D. Koronaki

Topology Optimization (TO) provides a systematic approach for obtaining structure design with optimum performance of interest. However, the process requires numerical evaluation of objective function and constraints at each iteration, which…

Machine Learning · Computer Science 2022-03-22 Ren Kai Tan , Chao Qian , Dan Xu , Wenjing Ye

Existing frameworks for LLM-based agent architectures describe systems from a single perspective: industry guides (Anthropic, Google, LangChain) focus on execution topology -- how data flows -- while cognitive science surveys focus on…

Artificial Intelligence · Computer Science 2026-05-26 Jia Huang , Joey Tianyi Zhou

We introduce ToPolyAgent, a multi-agent AI framework for performing coarse-grained molecular dynamics (MD) simulations of topological polymers through natural language instructions. By integrating large language models (LLMs) with…

Artificial Intelligence · Computer Science 2026-02-09 Lijie Ding , Jan-Michael Carrillo , Changwoo Do

Agentic systems, AI architectures that autonomously execute multi-step workflows to achieve complex goals, are often built using repeated large language model (LLM) calls for closed-set decision tasks such as routing, shortlisting, gating,…

Computation and Language · Computer Science 2026-02-19 Ido Levy , Eilam Shapira , Yinon Goldshtein , Avi Yaeli , Nir Mashkif , Segev Shlomov

Planning has become a central capability for contemporary agent systems in navigating complex, long-horizon tasks, yet existing approaches predominantly rely on fixed, hand-crafted planning structures that lack the flexibility to adapt to…

Computation and Language · Computer Science 2026-02-10 Jiaxi Liu , Yanzuo Jiang , Guibin Zhang , Zihan Zhang , Heng Chang , Zhenfei Yin , Qibing Ren , Junchi Yan

The design of alloys is a multi-scale problem that requires a holistic approach that involves retrieving relevant knowledge, applying advanced computational methods, conducting experimental validations, and analyzing the results, a process…

Artificial Intelligence · Computer Science 2024-07-16 Alireza Ghafarollahi , Markus J. Buehler

As the demand for artificial intelligence (AI) grows to address complex real-world tasks, single models are often insufficient, requiring the integration of multiple models into pipelines. This paper introduces Bel Esprit, a conversational…

Artificial Intelligence · Computer Science 2025-06-16 Yunsu Kim , AhmedElmogtaba Abdelaziz , Thiago Castro Ferreira , Mohamed Al-Badrashiny , Hassan Sawaf

Recent advances in code generation models have unlocked unprecedented opportunities for automating feature engineering, yet their adoption in real-world ML teams remains constrained by critical challenges: (i) the scarcity of datasets…

Machine Learning · Computer Science 2026-01-19 Himanshu Thakur , Anusha Kamath , Anurag Muthyala , Dhwani Sanmukhani , Smruthi Mukund , Jay Katukuri

Engineers learn from every design they create, building intuition that helps them quickly identify promising solutions for new problems. Topology optimization (TO) - a well-established computational method for designing structures with…

Computational Engineering, Finance, and Science · Computer Science 2025-02-05 Igor Kuszczak , Gawel Kus , Federico Bosi , Miguel A. Bessa

Effective prompt design is essential for improving the planning capabilities of large language model (LLM)-driven agents. However, existing structured prompting strategies are typically limited to single-agent, plan-only settings, and often…

Artificial Intelligence · Computer Science 2025-07-08 Bruce Yang , Xinfeng He , Huan Gao , Yifan Cao , Xiaofan Li , David Hsu

AI is increasingly used to accelerate engineering design by improving decision-making and shortening iteration cycles. Application to marine propeller design, however, remains challenging due to scarce training data and the lack of widely…

Computational Engineering, Finance, and Science · Computer Science 2026-04-27 Leah Chen , Keni Chih-Hua Wu , Boon Tat Chia , Xiuqing Xing , Jian Cheng Wong

Chemical process optimization maximizes production efficiency and economic performance, but optimization algorithms, including gradient-based solvers, numerical methods, and parameter grid searches, become impractical when operating…

Machine Learning · Computer Science 2025-10-17 Tong Zeng , Srivathsan Badrinarayanan , Janghoon Ock , Cheng-Kai Lai , Amir Barati Farimani

Large Language Model-based Multi-Agent Systems (MASs) have emerged as a powerful paradigm for tackling complex tasks through collaborative intelligence. However, the topology of these systems--how agents in MASs should be configured,…

Multiagent Systems · Computer Science 2025-10-20 Jiaxi Yang , Mengqi Zhang , Yiqiao Jin , Hao Chen , Qingsong Wen , Lu Lin , Yi He , Srijan Kumar , Weijie Xu , James Evans , Jindong Wang

Agentic AI denotes an architectural transition from stateless, prompt-driven generative models toward goal-directed systems capable of autonomous perception, planning, action, and adaptation through iterative control loops. This paper…

Software Engineering · Computer Science 2026-02-12 Mamdouh Alenezi

Agentic AI systems use specialized agents to handle tasks within complex workflows, enabling automation and efficiency. However, optimizing these systems often requires labor-intensive, manual adjustments to refine roles, tasks, and…

Computation and Language · Computer Science 2024-12-24 Kamer Ali Yuksel , Hassan Sawaf

We focus on the problem of designing an artificial agent (AI), capable of assisting a human user to complete a task. Our goal is to guide human users towards optimal task performance while keeping their cognitive load as low as possible.…

Robotics · Computer Science 2019-11-05 Gilwoo Lee , Christoforos Mavrogiannis , Siddhartha S. Srinivasa