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Similarity metrics have played a significant role in computer vision to capture the underlying semantics of images. In recent years, advanced similarity metrics, such as the Learned Perceptual Image Patch Similarity (LPIPS), have emerged.…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Sara Ghazanfari , Siddharth Garg , Prashanth Krishnamurthy , Farshad Khorrami , Alexandre Araujo

Hematoxylin and eosin (H&E)-stained slides are central to cancer diagnosis and monitoring, visualizing tissue architecture and cellular morphology. However, H&E lacks the molecular specificity needed to distinguish cell states and…

Image and Video Processing · Electrical Eng. & Systems 2026-04-14 Tushar Kataria , Beatrice Knudsen , Shireen Y. Elhabian

Immunohistochemical (IHC) virtual staining is a task that generates virtual IHC images from H\&E images while maintaining pathological semantic consistency with adjacent slices. This task aims to achieve cross-domain mapping between…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Yue Peng , Bing Xiong , Fuqiang Chen , De Eybo , RanRan Zhang , Wanming Hu , Jing Cai , Wenjian Qin

Hematoxylin and Eosin (H&E) staining is widely regarded as the standard in pathology for diagnosing diseases and tracking tumor recurrence. While H&E staining shows tissue structures, it lacks the ability to reveal specific proteins that…

Image and Video Processing · Electrical Eng. & Systems 2025-05-21 Tushar Kataria , Beatrice Knudsen , Shireen Y. Elhabian

The rapid development of digital pathology and modern deep learning has facilitated the emergence of pathology foundation models that are expected to solve general pathology problems under various disease conditions in one unified model,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-10 Yutong Sun , Sichen Zhu , Peng Qiu

Perceptual similarity scores that align with human vision are critical for both training and evaluating computer vision models. Deep perceptual losses, such as LPIPS, achieve good alignment but rely on complex, highly non-linear…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Paula Seidler , Neill D. F. Campbell , Ivor J A Simpson

Histopathology relies on the analysis of microscopic tissue images to diagnose disease. A crucial part of tissue preparation is staining whereby a dye is used to make the salient tissue components more distinguishable. However, differences…

Image and Video Processing · Electrical Eng. & Systems 2022-08-03 Haseeb Nazki , Ognjen Arandjelović , InHwa Um , David Harrison

Virtual staining leverages computer-aided techniques to transfer the style of histochemically stained tissue samples to other staining types. In virtual staining of pathological images, maintaining strict structural consistency is crucial,…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Bing Xiong , Yue Peng , RanRan Zhang , Fuqiang Chen , JiaYe He , Wenjian Qin

One of the fundamental elements of both traditional and certain deep learning medical image registration algorithms is measuring the similarity/dissimilarity between two images. In this work, we propose an analytical solution for measuring…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Mohammadreza Eskandari , Houssem-Eddine Gueziri , D. Louis Collins

Histopathological images (HIs) are the gold standard for evaluating some types of tumors for cancer diagnosis. The analysis of such images is not only time and resource consuming, but also very challenging even for experienced pathologists,…

Computer Vision and Pattern Recognition · Computer Science 2021-02-09 Jonathan de Matos , Steve Tsham Mpinda Ataky , Alceu de Souza Britto , Luiz Eduardo Soares de Oliveira , Alessandro Lameiras Koerich

This study introduces a novel metric, the Index of Visual Similarity (IVS), to qualitatively characterize boiling heat transfer regimes using only visual data. The IVS is constructed by combining morphological similarity, through SIFT-based…

Image and Video Processing · Electrical Eng. & Systems 2025-06-13 Pranay Nirapure , Ayushman Singh , Srikanth Rangarajan , Bahgat Sammakia

Color inconsistency is an inevitable challenge in computational pathology, which generally happens because of stain intensity variations or sections scanned by different scanners. It harms the pathological image analysis methods, especially…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Bingchao Zhao , Jiatai Lin , Changhong Liang , Zongjian Yi , Xin Chen , Bingbing Li , Weihao Qiu , Danyi Li , Li Liang , Chu Han , Zaiyi Liu

Histopathological staining of human tissue is essential for disease diagnosis. Recent advances in virtual tissue staining technologies using artificial intelligence (AI) alleviate some of the costly and tedious steps involved in traditional…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Luzhe Huang , Yuzhu Li , Nir Pillar , Tal Keidar Haran , William Dean Wallace , Aydogan Ozcan

Histopathological imaging is vital for cancer research and clinical practice, with multiplexed Immunofluorescence (MxIF) and Hematoxylin and Eosin (H&E) providing complementary insights. However, aligning different stains at the cell level…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Jun Jiang , Raymond Moore , Brenna Novotny , Leo Liu , Zachary Fogarty , Ray Guo , Markovic Svetomir , Chen Wang

Hyperspectral images (HIS) classification is a high technical remote sensing tool. The goal is to reproduce a thematic map that will be compared with a reference ground truth map (GT), constructed by expecting the region. The HIS contains…

Computer Vision and Pattern Recognition · Computer Science 2022-11-18 ELkebir Sarhrouni , Ahmed Hammouch , Driss Aboutajdine

Immunohistochemical (IHC) staining enables precise molecular profiling of protein expression, with over 200 clinically available antibody-based tests in modern pathology. However, comprehensive IHC analysis is frequently limited by…

Computer Vision and Pattern Recognition · Computer Science 2026-02-27 Fuqiang Chen , Ranran Zhang , Wanming Hu , Deboch Eyob Abera , Yue Peng , Boyun Zheng , Yiwen Sun , Jing Cai , Wenjian Qin

Generative virtual staining (VS) models for high-throughput screening (HTS) can provide an estimated posterior distribution of possible biological feature values for each input and cell. However, when evaluating a VS model, the true…

Machine Learning · Computer Science 2026-02-27 Samuel Tonks , Steve Hood , Ryan Musso , Ceridwen Hopely , Steve Titus , Minh Doan , Iain Styles , Alexander Krull

Histopathologic Images (HI) are the gold standard for evaluation of some tumors. However, the analysis of such images is challenging even for experienced pathologists, resulting in problems of inter and intra observer. Besides that, the…

Computer Vision and Pattern Recognition · Computer Science 2019-04-18 Jonathan de Matos , Alceu de Souza Britto , Luiz E. S. Oliveira , Alessandro L. Koerich

Recently, deep neural networks have greatly advanced histopathology image segmentation but usually require abundant annotated data. However, due to the gigapixel scale of whole slide images and pathologists' heavy daily workload, obtaining…

Computer Vision and Pattern Recognition · Computer Science 2023-03-13 Wentao Pan , Jiangpeng Yan , Hanbo Chen , Jiawei Yang , Zhe Xu , Xiu Li , Jianhua Yao

This paper presents a study on few-shot classification in the context of histopathology images. While few-shot learning has been studied for natural image classification, its application to histopathology is relatively unexplored. Given the…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Ardhendu Sekhar , Ravi Kant Gupta , Amit Sethi
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