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Scientific progress is driven by the deliberate articulation of what remains unknown. This study investigates the ability of large language models (LLMs) to identify research knowledge gaps in the biomedical literature. We define two…

Computation and Language · Computer Science 2025-10-30 Nourah M Salem , Elizabeth White , Michael Bada , Lawrence Hunter

Medical order extraction is essential for structuring actionable clinical information, supporting decision-making, and enabling downstream applications such as documentation and workflow automation. Orders may be embedded in diverse…

Computation and Language · Computer Science 2025-10-14 A H M Rezaul Karim , Ozlem Uzuner

Systematic reviews and meta-analyses rely on converting narrative articles into structured, numerically grounded study records. Despite rapid advances in large language models (LLMs), it remains unclear whether they can meet the structural…

Computation and Language · Computer Science 2026-02-12 Zhiyin Tan , Jennifer D'Souza

Large language models (LLMs) have excelled across domains, also delivering notable performance on the medical evaluation benchmarks, such as MedQA. However, there still exists a significant gap between the reported performance and the…

Computation and Language · Computer Science 2024-06-06 Yuxuan Zhou , Xien Liu , Chen Ning , Ji Wu

Large Language Models tend to struggle when dealing with specialized domains. While all aspects of evaluation hold importance, factuality is the most critical one. Similarly, reliable fact-checking tools and data sources are essential for…

Computation and Language · Computer Science 2025-09-03 Anum Afzal , Juraj Vladika , Florian Matthes

Clinical decisions are often required under incomplete information. Clinical experts must identify whether available information is sufficient for judgment, as both premature conclusion and unnecessary abstention can compromise patient…

Artificial Intelligence · Computer Science 2026-02-27 Yusuke Watanabe , Yohei Kobashi , Takeshi Kojima , Yusuke Iwasawa , Yasushi Okuno , Yutaka Matsuo

Systematic reviews in medicine play a critical role in evidence-based decision-making by aggregating findings from multiple studies. A central bottleneck in automating this process is extracting numeric evidence and determining study-level…

Artificial Intelligence · Computer Science 2026-01-26 Massimiliano Pronesti , Michela Lorandi , Paul Flanagan , Oisin Redmond , Anya Belz , Yufang Hou

The increasing volume of scholarly publications requires advanced tools for efficient knowledge discovery and management. This paper introduces ongoing work on a system using Large Language Models (LLMs) for the semantic extraction of key…

Digital Libraries · Computer Science 2025-10-07 Samy Ateia , Udo Kruschwitz , Melanie Scholz , Agnes Koschmider , Moayad Almohaishi

Large Language Models (LLMs) have transformed how people interact with artificial intelligence (AI) systems, achieving state-of-the-art results in various tasks, including scientific discovery and hypothesis generation. However, the lack of…

Computation and Language · Computer Science 2024-11-06 Sikun Guo , Amir Hassan Shariatmadari , Guangzhi Xiong , Albert Huang , Eric Xie , Stefan Bekiranov , Aidong Zhang

Clinical studies often require understanding elements of a patient's narrative that exist only in free text clinical notes. To transform notes into structured data for downstream use, these elements are commonly extracted and normalized to…

Computation and Language · Computer Science 2020-08-03 Monica Agrawal , Chloe O'Connell , Yasmin Fatemi , Ariel Levy , David Sontag

Large Language Models (LLMs) are increasingly adopted for applications in healthcare, reaching the performance of domain experts on tasks such as question answering and document summarisation. Despite their success on these tasks, it is…

Computation and Language · Computer Science 2025-05-20 Aishik Nagar , Viktor Schlegel , Thanh-Tung Nguyen , Hao Li , Yuping Wu , Kuluhan Binici , Stefan Winkler

Current medical language model (LM) benchmarks often over-simplify the complexities of day-to-day clinical practice tasks and instead rely on evaluating LMs on multiple-choice board exam questions. In psychiatry especially, these challenges…

While pioneering deep learning methods have made great strides in analyzing electronic health record (EHR) data, they often struggle to fully capture the semantics of diverse medical codes from limited data. The integration of external…

Machine Learning · Computer Science 2024-08-26 Zhihao Yu , Yujie Jin , Yongxin Xu , Xu Chu , Yasha Wang , Junfeng Zhao

Despite the remarkable advancements and widespread applications of deep neural networks, their ability to perform reasoning tasks remains limited, particularly in domains requiring structured, abstract thought. In this paper, we investigate…

Computation and Language · Computer Science 2025-09-16 Satyam Goyal , Soham Dan

Recent advances in multimodal large language models (MLLMs) have significantly improved medical AI, enabling it to unify the understanding of visual and textual information. However, as medical knowledge continues to evolve, it is critical…

Artificial Intelligence · Computer Science 2025-08-08 Dexuan Xu , Jieyi Wang , Zhongyan Chai , Yongzhi Cao , Hanpin Wang , Huamin Zhang , Yu Huang

Remarkable success has been achieved in the last few years on some limited machine reading comprehension (MRC) tasks. However, it is still difficult to interpret the predictions of existing MRC models. In this paper, we focus on extracting…

Computation and Language · Computer Science 2019-09-25 Hai Wang , Dian Yu , Kai Sun , Jianshu Chen , Dong Yu , David McAllester , Dan Roth

Large Language Models (LLMs) have shown promise in clinical applications through prompt engineering, allowing flexible clinical predictions. However, they struggle to produce reliable prediction probabilities, which are crucial for…

Artificial Intelligence · Computer Science 2024-12-05 Bowen Gu , Rishi J. Desai , Kueiyu Joshua Lin , Jie Yang

The advent of Large Language Models (LLMs) offers potential solutions to address problems such as shortage of medical resources and low diagnostic consistency in psychiatric clinical practice. Despite this potential, a robust and…

Computation and Language · Computer Science 2025-06-19 Shuyu Liu , Ruoxi Wang , Ling Zhang , Xuequan Zhu , Rui Yang , Xinzhu Zhou , Fei Wu , Zhi Yang , Cheng Jin , Gang Wang

Visual grounding is essential for precise perception and reasoning in multimodal large language models (MLLMs), especially in medical imaging domains. While existing medical visual grounding benchmarks primarily focus on single-image…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Jingkun Yue , Siqi Zhang , Zinan Jia , Huihuan Xu , Zongbo Han , Xiaohong Liu , Guangyu Wang

Medical concept normalization helps in discovering standard concepts in free-form text i.e., maps health-related mentions to standard concepts in a vocabulary. It is much beyond simple string matching and requires a deep semantic…

Computation and Language · Computer Science 2020-06-09 Katikapalli Subramanyam Kalyan , S. Sangeetha