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Large Language Models (LLMs) and multi-agent systems have shown impressive capabilities in natural language tasks but face challenges in clinical trial applications, primarily due to limited access to external knowledge. Recognizing the…

Computation and Language · Computer Science 2024-07-23 Ling Yue , Sixue Xing , Jintai Chen , Tianfan Fu

While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis. Existing methods typically rely on static, linear mappings…

Computation and Language · Computer Science 2026-05-28 Zhuohan Ge , Haoyang Li , Yubo Wang , Nicole Hu , Chen Jason Zhang , Qing Li

Evaluating large language models (LLM) in clinical scenarios is crucial to assessing their potential clinical utility. Existing benchmarks rely heavily on static question-answering, which does not accurately depict the complex, sequential…

Human-Computer Interaction · Computer Science 2025-05-27 Samuel Schmidgall , Rojin Ziaei , Carl Harris , Eduardo Reis , Jeffrey Jopling , Michael Moor

Large language models (LLMs) show promise for healthcare question answering, but clinical use is limited by weak verification, insufficient evidence grounding, and unreliable confidence signalling. We propose a multi-agent medical QA…

Computation and Language · Computer Science 2026-02-17 Naeimeh Nourmohammadi , Md Meem Hossain , The Anh Han , Safina Showkat Ara , Zia Ush Shamszaman

Clinical diagnosis is a complex reasoning process in which clinicians gather evidence, form hypotheses, and test them against alternative explanations. In medical training, this reasoning is explicitly developed through counterfactual…

Computation and Language · Computer Science 2026-04-24 Zhiwen You , Xi Chen , Aniket Vashishtha , Simo Du , Gabriel Erion-Barner , Hongyuan Mei , Hao Peng , Yue Guo

In modern medicine, clinical diagnosis relies on the comprehensive analysis of primarily textual and visual data, drawing on medical expertise to ensure systematic and rigorous reasoning. Recent advances in large Vision-Language Models…

Artificial Intelligence · Computer Science 2025-07-03 Ziyue Wang , Junde Wu , Linghan Cai , Chang Han Low , Xihong Yang , Qiaxuan Li , Yueming Jin

We introduce Agentic Reasoning, a framework that enhances large language model (LLM) reasoning by integrating external tool-using agents. Agentic Reasoning dynamically leverages web search, code execution, and structured memory to address…

Artificial Intelligence · Computer Science 2025-07-16 Junde Wu , Jiayuan Zhu , Yuyuan Liu , Min Xu , Yueming Jin

Clinical decision-making requires nuanced reasoning over heterogeneous evidence and traceable justifications. While recent LLM multi-agent systems (MAS) show promise, they largely optimise for outcome accuracy while overlooking…

Artificial Intelligence · Computer Science 2026-02-17 Chaeeun Lee , T. Michael Yates , Pasquale Minervini , T. Ian Simpson

The rapid spread of misinformation in the digital era poses significant challenges to public discourse, necessitating robust and scalable fact-checking solutions. Traditional human-led fact-checking methods, while credible, struggle with…

Artificial Intelligence · Computer Science 2025-06-24 Tam Trinh , Manh Nguyen , Truong-Son Hy

Climate research is pivotal for mitigating global environmental crises, yet the accelerating volume of multi-scale datasets and the complexity of analytical tools have created significant bottlenecks, constraining scientific discovery to…

Artificial Intelligence · Computer Science 2026-04-28 Hao Wang , Jindong Han , Wei Fan , Hao Liu

Large language models (LLMs) offer substantial promise for automating clinical text summarization, yet maintaining factual consistency remains challenging due to the length, noise, and heterogeneity of clinical documentation. We present…

Computation and Language · Computer Science 2026-02-24 Fahmida Liza Piya , Rahmatollah Beheshti

Chest X-ray plays a central role in thoracic diagnosis, and its interpretation inherently requires multi-step, evidence-grounded reasoning. However, large vision-language models (LVLMs) often generate plausible responses that are not…

Artificial Intelligence · Computer Science 2026-03-25 Hyungyung Lee , Hangyul Yoon , Edward Choi

Large language models perform well on static medical examinations, yet clinical diagnosis often requires iterative evidence gathering under uncertainty. Building on prior interactive evaluation efforts, we introduce an OSCE-inspired…

Artificial Intelligence · Computer Science 2026-05-22 Chen Zhan , Xihe Qiu , Xiaoyu Tan , Xibing Zhuang , Gengchen Ma , Yue Zhang , Shuo Li , Peifeng Liu , Xiaoxiao Ge , Liang Liu , Lu Gan

Clinical Decision Support Systems (CDSSs) provide reasoning and inquiry guidance for physicians, yet they face notable challenges, including high maintenance costs and low generalization capability. Recently, Large Language Models (LLMs)…

Computation and Language · Computer Science 2026-04-24 Yue Guo , Fanfu Wang , Jianwei Lv , Xincheng Shi , Yuchen Li , Youya Wang , Yunsheng Zeng , Yujing Liu , Yunhao Qiao , Gen Li , Junfeng Wang , Bo Yuan

Clinical decision-making is inherently complex and fast-paced, particularly in emergency departments (EDs) where critical, rapid and high-stakes decisions are made. Clinical Decision Rules (CDRs) are standardized evidence-based tools that…

Large Language Models (LLMs) have revolutionized recommendation agents by providing superior reasoning and flexible decision-making capabilities. However, existing methods mainly follow a passive information acquisition paradigm, where…

Information Retrieval · Computer Science 2026-03-11 Haobo Zhang , Yutao Zhu , Kelong Mao , Tianhao Li , Zhicheng Dou

Large Language Models (LLMs) have shown impressive performance on existing medical question-answering benchmarks. This high performance makes it increasingly difficult to meaningfully evaluate and differentiate advanced methods. We present…

Computation and Language · Computer Science 2025-03-21 Xiangru Tang , Daniel Shao , Jiwoong Sohn , Jiapeng Chen , Jiayi Zhang , Jinyu Xiang , Fang Wu , Yilun Zhao , Chenglin Wu , Wenqi Shi , Arman Cohan , Mark Gerstein

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by grounding responses with retrieved information. As an emerging paradigm, Agentic RAG further enhances this process by introducing autonomous LLM agents into the…

Information Retrieval · Computer Science 2025-05-26 Yunjia Xi , Jianghao Lin , Menghui Zhu , Yongzhao Xiao , Zhuoying Ou , Jiaqi Liu , Tong Wan , Bo Chen , Weiwen Liu , Yasheng Wang , Ruiming Tang , Weinan Zhang , Yong Yu

This paper introduces SignAgent, a novel agentic framework that utilises Large Language Models (LLMs) for scalable, linguistically-grounded Sign Language (SL) annotation and dataset curation. Traditional computational methods for SLs often…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Oliver Cory , Ozge Mercanoglu Sincan , Richard Bowden

Large language models (LLMs) exhibit strong symbolic and compositional reasoning, yet they struggle with time series question answering as the data is typically transformed into an LLM-compatible modality, e.g., serialized text, plotted…

Artificial Intelligence · Computer Science 2026-04-08 Penghang Liu , Elizabeth Fons , Annita Vapsi , Mohsen Ghassemi , Svitlana Vyetrenko , Daniel Borrajo , Vamsi K. Potluru , Manuela Veloso
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