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A central need in the field of astrobiology is generalized perspectives on life that make it possible to differentiate abiotic and biotic chemical systems. A key component of many past and future astrobiological measurements is the…

Quantitative Methods · Quantitative Biology 2020-11-05 Christopher P. Kempes , Michael J. Follows , Hillary Smith , Heather Graham , Christopher H. House , Simon A. Levin

The search for extraterrestrial life hinges on identifying biosignatures, often focusing on gaseous metabolic byproducts as indicators. However, most such biosignatures require assuming specific metabolic processes. It is widely recognized…

Populations and Evolution · Quantitative Biology 2024-12-24 Akshit Goyal , Mikhail Tikhonov

Organisms leave a distinctive chemical signature in their environment because they synthesize those molecules that maximize their fitness. As a result, the relative concentrations of related chemical monomers in life-bearing environmental…

Biomolecules · Quantitative Biology 2011-05-05 Evan D. Dorn , Kenneth H. Nealson , Christoph Adami

The search for life in the Solar System hinges on data from planetary missions. Detecting biosignatures based on molecular identity, isotopic composition, or chiral excess requires measurements that current and planned missions can only…

Earth and Planetary Astrophysics · Physics 2026-04-10 Gideon Yoffe , Fabian Klenner , Barak Sober , Yohai Kaspi , Itay Halevy

Rapid, non-destructive characterization of molecular level chemistry for organic matter (OM) is experimentally challenging. Raman spectroscopy is one of the most widely used techniques for non-destructive chemical characterization, although…

Materials Science · Physics 2016-02-08 Yun Liu , Nicola Ferralis , L. Taras Bryndzia , Jeffrey C. Grossman

Assembly theory predicts that a distinguishing signature of life is its ability to produce complex molecules in abundance, opening new possibilities for life detection. Experimental validation of this approach has so far relied on abiotic…

Biological Physics · Physics 2025-09-08 Alexandre Champagne-Ruel , Christopher P. Kempes , Cole Mathis

Building blocks of life such as amino acids, nucleobases, and fatty acids are central to prebiotic chemistry and represent key targets in the search for planetary biosignatures. In planetary materials, biomolecules typically occur at trace…

Earth and Planetary Astrophysics · Physics 2026-03-31 Xiaoou Luo , Chao He , Zhengbo Yang , Yingjian Wang , Ziyao Fang , Yu Liu , Sai Wang , Haixin Li

Finding life on exoplanets from telescopic observations is an ultimate goal of exoplanet science. Life produces gases and other substances, such as pigments, which can have distinct spectral or photometric signatures. Whether or not life is…

Molecular assembly offers a promising path to detect life beyond Earth, while minimizing assumptions based on terrestrial life. As mass spectrometers will be central to upcoming Solar System missions, predicting molecular assembly from…

Machine Learning · Computer Science 2025-07-28 Lindsay A. Rutter , Abhishek Sharma , Ian Seet , David Obeh Alobo , An Goto , Leroy Cronin

One thing that discriminates living things from inanimate matter is their ability to generate similarly complex or non-random architectures in a large abundance. From DNA sequences to folded protein structures, living cells, microbial…

Other Quantitative Biology · Quantitative Biology 2018-02-07 Stuart M. Marshall , Alastair R. G. Murray , Leroy Cronin

Spectral characterization of Super-Earth atmospheres for planets orbiting in the Habitable Zone of M-dwarf stars is a key focus in exoplanet science. A central challenge is to understand and predict the expected spectral signals of…

Earth and Planetary Astrophysics · Physics 2015-06-15 J. L. Grenfell , S. Gebauer , M. Godolt , K. Palczynski , H. Rauer , J. Stock , P. v. Paris , R. Lehmann , F. Selsis

In the coming years and decades, advanced space- and ground-based observatories will allow an unprecedented opportunity to probe the atmospheres and surfaces of potentially habitable exoplanets for signatures of life. Life on Earth, through…

We present a novel approach to generate a fingerprint for crystalline materials that balances efficiency for machine processing and human interpretability, allowing its application in both machine learning inference and understanding of…

Materials Science · Physics 2025-03-21 Tiago F. T. Cerqueira , Haichen Wang , Silvana Botti , Miguel A. L. Marques

Ecology studies biodiversity in its variety and complexity. It describes how species distribute and perform in response to environmental changes. Ecological processes and structures are highly complex and adaptive. In order to quantify…

Populations and Evolution · Quantitative Biology 2013-10-09 Cang Hui

Chemical disequilibrium quantified via available free energy has previously been proposed as a potential biosignature. However, exoplanet biosignature remote sensing work has not yet investigated how observational uncertainties impact the…

The search for life on exoplanets is one of the grand scientific challenges of our time. The strategy to date has been to find (e.g., through transit surveys like Kepler) Earth-like exoplanets in their stars habitable zone, then use…

Ocean worlds are considered as targets for life detection missions because they meet several key requirements for habitability. However, identifying potential life on other worlds requires observing clear and unambiguous biosignature…

Earth and Planetary Astrophysics · Physics 2026-05-18 Peter M. Higgins , Weibin Chen , Oliver Warr , Lucas M. Fifer , Wanying Kang , Charles S. Cockell , Barbara Sherwood Lollar

With the characterisations of potentially habitable planetary atmospheres on the horizon, the search for biosignatures is set to become a major area of research in the coming decades. To understand the atmospheric characteristics that might…

Earth and Planetary Astrophysics · Physics 2022-08-17 A. E. Nicholson , S. J. Daines , N. J. Mayne , J. K. Eager-Nash , T. M. Lenton , K. Kohary

Element synthesis which started with p-p chain has resulted in several specific characteristics including lack of any stable isotope having atomic masses 5 or 8. The carbon to oxygen ratio is fixed early by the chain of coincidences. These,…

Astrophysics of Galaxies · Physics 2016-05-30 Vlado Valkovic

Here we review how environmental context can be used to interpret whether O2 is a biosignature in extrasolar planetary observations. This paper builds on the overview of current biosignature research discussed in Schwieterman et al. (2017),…

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