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Noisy data and the similarity in the ocular appearances caused by different ophthalmic pathologies pose significant challenges for an automated expert system to accurately detect retinal diseases. In addition, the lack of knowledge…

Image and Video Processing · Electrical Eng. & Systems 2021-10-20 Sharif Amit Kamran , Alireza Tavakkoli , Stewart Lee Zuckerbrod

Aging is a multidimensional process where phenotypes change at varying rates. Longitudinal studies of aging typically involve following a cohort of individuals over the course of several years. This design is hindered by cost, attrition,…

Deep neural networks have shown impressive performance for image-based disease detection. Performance is commonly evaluated through clinical validation on independent test sets to demonstrate clinically acceptable accuracy. Reporting good…

Image and Video Processing · Electrical Eng. & Systems 2023-09-18 Mobarakol Islam , Zeju Li , Ben Glocker

A key condition for obtaining reliable estimates of the causal effect of a treatment is overlap (a.k.a. positivity): the distributions of the features used to perform causal adjustment cannot be too different in the treated and control…

Methodology · Statistics 2021-04-14 Alexander D'Amour , Alexander Franks

Studying causal effects of continuous treatments is important for gaining a deeper understanding of many interventions, policies, or medications, yet researchers are often left with observational studies for doing so. In the observational…

Methodology · Statistics 2023-06-16 Jared D. Huling , Noah Greifer , Guanhua Chen

Medical multimodal representation learning aims to integrate heterogeneous data into unified patient representations to support clinical outcome prediction. However, real-world medical datasets commonly contain systematic biases from…

Machine Learning · Computer Science 2026-05-19 Xiaoguang Zhu , Linxiao Gong , Lianlong Sun , Yang Liu , Haoyu Wang , Jing Liu

Consider a scenario where we have access to train data with both covariates and outcomes while test data only contains covariates. In this scenario, our primary aim is to predict the missing outcomes of the test data. With this objective in…

Methodology · Statistics 2024-10-29 Masahiro Kato , Kota Matsui , Ryo Inokuchi

Recent advancements in medicine have confirmed that brain disorders often comprise multiple subtypes of mechanisms, developmental trajectories, or severity levels. Such heterogeneity is often associated with demographic aspects (e.g., sex)…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Magdalini Paschali , Yu Hang Jiang , Spencer Siegel , Camila Gonzalez , Kilian M. Pohl , Akshay Chaudhari , Qingyu Zhao

Early detection of patient deterioration is essential for timely treatment, with vital signs like heart rates being key health indicators. Existing methods tend to solely analyze vital sign waveforms, ignoring transition relationships of…

Machine Learning · Computer Science 2025-06-04 Lo Pang-Yun Ting , Zhen Tan , Hong-Pei Chen , Cheng-Te Li , Po-Lin Chen , Kun-Ta Chuang , Huan Liu

We investigate the performance of grid-based techniques in estimating the age of stars in detached eclipsing binary systems. We evaluate the precision of the estimates due to the uncertainty in the observational constraints, and the…

Solar and Stellar Astrophysics · Physics 2015-07-01 G. Valle , M. Dell'Omodarme , P. G. Prada Moroni , S. Degl'Innocenti

Although deep learning models in medical imaging often achieve excellent classification performance, they can rely on shortcut learning, exploiting spurious correlations or confounding factors that are not causally related to the target…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Sarah Müller , Philipp Berens

Over the years, there has been growing interest in using Machine Learning techniques for biomedical data processing. When tackling these tasks, one needs to bear in mind that biomedical data depends on a variety of characteristics, such as…

Machine Learning · Computer Science 2020-02-05 Elisa Ferrari , Alessandra Retico , Davide Bacciu

Causal or unconfounded descriptive comparisons between multiple groups are common in observational studies. Motivated from a racial disparity study in health services research, we propose a unified propensity score weighting framework, the…

Methodology · Statistics 2019-07-10 Fan Li , Fan Li

Widespread population aging has made it critical to understand death rates at old ages. However, studying mortality at old ages is challenging because the data are sparse: numbers of survivors and deaths get smaller and smaller with age. We…

Applications · Statistics 2018-03-29 Dennis M. Feehan

Demographic attributes such as age, sex, and race can be predicted from medical images, raising concerns about bias in clinical AI systems. In brain MRI, this signal may arise from anatomical variation, acquisition-dependent contrast…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Mehmet Yigit Avci , Akshit Achara , Andrew King , Jorge Cardoso

High-dimensional data acquired from biological experiments such as next generation sequencing are subject to a number of confounding effects. These effects include both technical effects, such as variation across batches from instrument…

Machine Learning · Computer Science 2018-12-11 Kabir Manghnani , Adam Drake , Nathan Wan , Imran Haque

In this work we propose a novel deep-learning approach for age estimation based on face images. We first introduce a dual image augmentation-aggregation approach based on attention. This allows the network to jointly utilize multiple face…

Computer Vision and Pattern Recognition · Computer Science 2023-09-29 Shakediel Hiba , Yosi Keller

Identifying frail older adults in an ageing population is essential for improving healthcare services. This study proposes a composite indicator to assess individual frailty levels using administrative healthcare data. Given the complex and…

Methodology · Statistics 2025-10-07 Sara Rebottini , Pietro Belloni

The Convolutional Neural Network has amazed us with its usage on several applications. Age range estimation using CNN is emerging due to its application in myriad of areas which makes it a state-of-the-art area for research and improve the…

Computer Vision and Pattern Recognition · Computer Science 2021-04-20 Dipesh Gyawali , Prashanga Pokharel , Ashutosh Chauhan , Subodh Chandra Shakya

Disentangling pathological changes from physiological aging in 3D medical shapes is crucial for developing interpretable biomarkers and patient stratification. However, this separation is challenging when diagnosis labels are limited or…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Jakaria Rabbi , Nilanjan Ray , Dana Cobzas