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Multimodal clinical prediction faces three challenges: multiple foundation models (FMs) with complementary strengths per modality, pervasive missing modalities at training and test time, and sample-specific variation in modality…

Machine Learning · Computer Science 2026-05-19 Seungik Cho , Anqi Li , Wei Qiu

One-dimensional nuclear magnetic resonance (NMR) spectroscopy is essential for molecular structure elucidation in organic synthesis, drug discovery, natural product characterization, and metabolomics, yet its interpretation remains heavily…

Evaluating the performance of Multi-modal Large Language Models (MLLMs), integrating both point cloud and language, presents significant challenges. The lack of a comprehensive assessment hampers determining whether these models truly…

Computer Vision and Pattern Recognition · Computer Science 2024-04-24 Junjie Zhang , Tianci Hu , Xiaoshui Huang , Yongshun Gong , Dan Zeng

Multimodal large language models (MLLMs) hold significant potential in medical applications, including disease diagnosis and clinical decision-making. However, these tasks require highly accurate, context-sensitive, and professionally…

Computation and Language · Computer Science 2025-09-01 Meidan Ding , Jipeng Zhang , Wenxuan Wang , Cheng-Yi Li , Wei-Chieh Fang , Hsin-Yu Wu , Haiqin Zhong , Wenting Chen , Linlin Shen

Multimodal large language models (MLLMs) have shown great potential in medical applications, yet existing benchmarks inadequately capture real-world clinical complexity. We introduce MEDSYN, a multilingual, multimodal benchmark of highly…

Computation and Language · Computer Science 2026-04-20 Boqi Chen , Xudong Liu , Jiachuan Peng , Marianne Frey-Marti , Bang Zheng , Kyle Lam , Lin Li , Jianing Qiu

While multimodal large language models (MLLMs) have made significant strides in natural image understanding, their ability to perceive and reason over hyperspectral image (HSI) remains underexplored, which is a vital modality in remote…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Xinyu Zhang , Zurong Mai , Qingmei Li , Zjin Liao , Yibin Wen , Yuhang Chen , Xiaoya Fan , Chan Tsz Ho , Bi Tianyuan , Haoyuan Liang , Ruifeng Su , Zihao Qian , Juepeng Zheng , Jianxi Huang , Yutong Lu , Haohuan Fu

Laser speckle, the granular intensity pattern arising from random optical interference, provides a high-dimensional encoding of spectral information that can be exploited for precision metrology. Speckle-based spectrometers have advanced…

Molecular Relational Learning (MRL) aims to understand interactions between molecular pairs, playing a critical role in advancing biochemical research. With the recent development of large language models (LLMs), a growing number of studies…

Machine Learning · Computer Science 2025-06-03 Zhuo Chen , Yizhen Zheng , Huan Yee Koh , Hongxin Xiang , Linjiang Chen , Wenjie Du , Yang Wang

Deep learning holds immense promise for spectroscopy, yet research and evaluation in this emerging field often lack standardized formulations. To address this issue, we introduce SpectrumLab, a pioneering unified platform designed to…

In recent years, large language models (LLMs) have transformed natural language understanding through vast datasets and large-scale parameterization. Inspired by this success, we present SpecCLIP, a foundation model framework that extends…

Instrumentation and Methods for Astrophysics · Physics 2025-12-22 Xiaosheng Zhao , Yang Huang , Guirong Xue , Xiao Kong , Jifeng Liu , Xiaoyu Tang , Timothy C. Beers , Yuan-Sen Ting , A-Li Luo

We introduce two new benchmarks REST and REST+ (Render-Equivalence Stress Tests) to enable systematic evaluation of cross-modal inconsistency in multimodal large language models (MLLMs). MLLMs are trained to represent vision and language in…

Artificial Intelligence · Computer Science 2026-04-23 Angela van Sprang , Laurens Samson , Ana Lucic , Erman Acar , Sennay Ghebreab , Yuki M. Asano

Multimodal Large Language Models (MLLMs) have shown significant potential in medical image analysis. However, their capabilities in interpreting fundus images, a critical skill for ophthalmology, remain under-evaluated. Existing benchmarks…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Qijie Wei , Kaiheng Qian , Xirong Li

Previous multilingual benchmarks focus primarily on simple understanding tasks, but for large language models(LLMs), we emphasize proficiency in instruction following, reasoning, long context understanding, code generation, and so on.…

Computation and Language · Computer Science 2025-04-22 Xu Huang , Wenhao Zhu , Hanxu Hu , Conghui He , Lei Li , Shujian Huang , Fei Yuan

We introduce OPENXRD, a comprehensive benchmarking framework for evaluating large language models (LLMs) and multimodal LLMs (MLLMs) in crystallography question answering. The framework measures context assimilation, or how models use…

Computation and Language · Computer Science 2026-03-11 Ali Vosoughi , Ayoub Shahnazari , Yufeng Xi , Zeliang Zhang , Griffin Hess , Chenliang Xu , Niaz Abdolrahim

Multimodal Large Language Models (MLLMs) are gaining increasing popularity in both academia and industry due to their remarkable performance in various applications such as visual question answering, visual perception, understanding, and…

Computation and Language · Computer Science 2024-09-09 Jian Li , Weiheng Lu , Hao Fei , Meng Luo , Ming Dai , Min Xia , Yizhang Jin , Zhenye Gan , Ding Qi , Chaoyou Fu , Ying Tai , Wankou Yang , Yabiao Wang , Chengjie Wang

Multimodal manifold modeling methods extend the spectral geometry-aware data analysis to learning from several related and complementary modalities. Most of these methods work based on two major assumptions: 1) there are the same number of…

Machine Learning · Computer Science 2021-05-13 Maysam Behmanesh , Peyman Adibi , Jocelyn Chanussot , Sayyed Mohammad Saeed Ehsani

Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Junzhi Ning , Jiashi Lin , Yingying Fang , Wei Li , Jiyao Liu , Cheng Tang , Chenglong Ma , Wenhao Tang , Tianbin Li , Ziyan Huang , Guang Yang , Junjun He

Medical Vision-Language Pretraining (MedVLP) shows promise in learning generalizable and transferable visual representations from paired and unpaired medical images and reports. MedVLP can provide useful features to downstream tasks and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Yang Zhou , Tan Li Hui Faith , Yanyu Xu , Sicong Leng , Xinxing Xu , Yong Liu , Rick Siow Mong Goh

Existing large language model (LLM) evaluation benchmarks primarily focus on English, while current multilingual tasks lack parallel questions that specifically assess cross-linguistic reasoning abilities. This dual limitation makes it…

Multimodal large language models (MLLMs) have shown great potential in perception and interpretation tasks, but their capabilities in predictive reasoning remain under-explored. To address this gap, we introduce a novel benchmark that…

Computer Vision and Pattern Recognition · Computer Science 2023-10-23 Mingwei Zhu , Leigang Sha , Yu Shu , Kangjia Zhao , Tiancheng Zhao , Jianwei Yin