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One of the grand challenges of artificial general intelligence is developing agents capable of conducting scientific research and discovering new knowledge. While frontier models have already been used as aides to human scientists, e.g. for…

Artificial Intelligence · Computer Science 2024-09-04 Chris Lu , Cong Lu , Robert Tjarko Lange , Jakob Foerster , Jeff Clune , David Ha

As AI promises to accelerate scientific discovery, it remains unclear whether fully AI-driven research is possible and whether it can adhere to key scientific values, such as transparency, traceability and verifiability. Mimicking human…

Other Quantitative Biology · Quantitative Biology 2024-04-30 Tal Ifargan , Lukas Hafner , Maor Kern , Ori Alcalay , Roy Kishony

Scientific peer review faces mounting strain as submission volumes surge, making it increasingly difficult to sustain review quality, consistency, and timeliness. Recent advances in AI have led the community to consider its use in peer…

Scientific research is being reshaped by AI systems that move beyond isolated assistance toward longer-horizon workflows spanning literature grounding, hypothesis generation, experimentation, validation, reporting, and revision. This shift…

Many leading AI researchers expect AI development to exceed the transformative impact of all previous technological revolutions. This belief is based on the idea that AI will be able to automate the process of AI research itself, leading to…

Computers and Society · Computer Science 2026-03-09 Severin Field , Raymond Douglas , David Krueger

Artificial intelligence (AI) tools are being incorporated into scientific research workflows with the potential to enhance efficiency in tasks such as document analysis, question answering (Q&A), and literature search. However, system…

Artificial Intelligence · Computer Science 2026-05-13 Anthea Dathe , Kiran Hoffmann , Aline Mangold

Numerous studies have assessed the proficiency of AI systems, particularly large language models (LLMs), in facilitating everyday tasks such as email writing, question answering, and creative content generation. However, researchers face…

Autonomous scientific research is significantly advanced thanks to the development of AI agents. One key step in this process is finding the right scientific literature, whether to explore existing knowledge for a research problem, or to…

We report a case study of four end-to-end attempts to autonomously generate ML research papers using a pipeline of six LLM agents mapped to stages of the scientific workflow. Of these four, three attempts failed during implementation or…

Machine Learning · Computer Science 2026-01-08 Dhruv Trehan , Paras Chopra

Peer review remains the central quality-control mechanism of science, yet its ability to fulfill this role is increasingly strained. Empirical studies document serious shortcomings: long publication delays, escalating reviewer burden…

Recent advancements in large language models have sparked interest in utilizing them to aid the peer review process of scientific publication amid the peer review crisis. However, having AI models generate full reviews in the same way as…

Computation and Language · Computer Science 2026-04-03 Tianmai M. Zhang , Neil F. Abernethy

The powerful reasoning capabilities of Large Language Models (LLMs) in mathematics and coding, combined with their ability to automate complex tasks through agentic frameworks, present unprecedented opportunities for accelerating scientific…

Artificial Intelligence · Computer Science 2025-05-27 Jiabin Tang , Lianghao Xia , Zhonghang Li , Chao Huang

Artificial intelligence is undergoing a profound transition from a computational instrument to an autonomous originator of scientific knowledge. This emerging paradigm, the AI scientist, is architected to emulate the complete scientific…

Artificial Intelligence · Computer Science 2026-01-21 Guiyao Tie , Pan Zhou , Lichao Sun

The use of artificial intelligence (AI) in research across all disciplines is becoming ubiquitous. However, this ubiquity is largely driven by hyperspecific AI models developed during scientific studies for accomplishing a well-defined,…

Computers and Society · Computer Science 2023-12-19 Rishab Jain , Aditya Jain

Large Language Models have seen expanding application across domains, yet their effectiveness as assistive tools for scientific writing - an endeavor requiring precision, multimodal synthesis, and domain expertise - remains insufficiently…

Human-Computer Interaction · Computer Science 2026-01-28 Sanchaita Hazra , Doeun Lee , Bodhisattwa Prasad Majumder , Sachin Kumar

Autonomous research systems capable of generating complete scientific manuscripts have advanced rapidly, yet robust and realistic evaluation frameworks have failed to keep pace. To bridge this gap, we introduce MLReplicate, an end-to-end…

Machine Learning · Computer Science 2026-05-19 Sasi Kiran Gaddipati , Diyana Muhammed , Farhana Keya , Gollam Rabby , Sören Auer

The field of AI research is advancing at an unprecedented pace, enabling automated hypothesis generation and experimental design across diverse domains such as biology, mathematics, and artificial intelligence. Despite these advancements,…

Machine Learning · Computer Science 2025-10-07 Yaowenqi Liu , Bingxu Meng , Rui Pan , Yuxing Liu , Jerry Huang , Jiaxuan You , Tong Zhang

Automating scientific discovery requires more than generating papers from ideas. Real research is iterative: hypotheses are challenged from multiple perspectives, experiments fail and inform the next attempt, and lessons accumulate across…

Large-scale Language Models (LLMs) have revolutionized human-AI interaction and achieved significant success in the generation of novel ideas. However, current assessments of idea generation overlook crucial factors such as knowledge…

Artificial Intelligence · Computer Science 2025-05-27 Yansheng Qiu , Haoquan Zhang , Zhaopan Xu , Ming Li , Diping Song , Zheng Wang , Kaipeng Zhang

AI research agents can now generate research ideas, design experiments, run code, and draft papers, raising the possibility of large-scale AI-assisted scientific discovery. Many current agent frameworks explicitly encourage the generation…

Computation and Language · Computer Science 2026-05-28 Yixuan Tang , Yi Yang
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