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We introduce a novel gene regulatory network (GRN) inference method that integrates optimal transport (OT) with a deep-learning structural inference model. Advances in next-generation sequencing enable detailed yet destructive gene…

Computational Engineering, Finance, and Science · Computer Science 2024-09-24 Tsz Pan Tong , Aoran Wang , George Panagopoulos , Jun Pang

Single-cell RNA sequencing (scRNA-seq) technologies have enabled the profiling of gene expression for a collection of cells across time during a dynamic biological process. Given that each time point provides only a static snapshot,…

Applications · Statistics 2025-06-16 Binghao Yan , Hongzhe Li

This paper proposes a simple self-supervised approach for learning a representation for visual correspondence from raw video. We cast correspondence as prediction of links in a space-time graph constructed from video. In this graph, the…

Computer Vision and Pattern Recognition · Computer Science 2020-12-04 Allan Jabri , Andrew Owens , Alexei A. Efros

3D medical image generation is essential for data augmentation and patient privacy, calling for reliable and efficient models suited for clinical practice. However, current methods suffer from limited anatomical fidelity, restricted axial…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Minye Shao , Xingyu Miao , Haoran Duan , Zeyu Wang , Jingkun Chen , Yawen Huang , Xian Wu , Jingjing Deng , Yang Long , Yefeng Zheng

9-1-1 call-taking training requires mastery of over a thousand interdependent skills, covering diverse incident types and protocol-specific nuances. A nationwide labor shortage is already straining training capacity, but effective…

Artificial Intelligence · Computer Science 2026-03-06 Zirong Chen , Hongchao Zhang , Meiyi Ma

Ensemble models achieve state-of-the-art performance on prediction tasks, but usually require aggregating a large number of weak learners. This can hinder deployment, interpretability, and downstream tasks such as robustness verification.…

Machine Learning · Computer Science 2026-05-08 Fabian Akkerman , Julien Ferry , Théo Guyard , Thibaut Vidal

Single-cell sequencing is revolutionizing biology by enabling detailed investigations of cell-state transitions. Many biological processes unfold along continuous trajectories, yet it remains challenging to extract smooth, low-dimensional…

Machine Learning · Statistics 2025-06-30 Rong Ma , Xi Li , Jingyuan Hu , Bin Yu

Distance measures between graphs are important primitives for a variety of learning tasks. In this work, we describe an unsupervised, optimal transport based approach to define a distance between graphs. Our idea is to derive…

Computational Engineering, Finance, and Science · Computer Science 2024-04-11 Michael Scholkemper , Damin Kühn , Gerion Nabbefeld , Simon Musall , Björn Kampa , Michael T. Schaub

Imputing missing values in spatial-temporal traffic data is essential for intelligent transportation systems. Among advanced imputation methods, score-based diffusion models have demonstrated competitive performance. These models generate…

Machine Learning · Computer Science 2026-01-09 Xiaowei Mao , Huihu Ding , Yan Lin , Tingrui Wu , Shengnan Guo , Dazhuo Qiu , Feiling Fang , Jilin Hu , Huaiyu Wan

Inferring cellular trajectories from destructive snapshots is complicated by the challenges of stochasticity and non-conservative mass dynamics such as cell proliferation and apoptosis. Existing unbalanced Optimal Transport (OT) methods…

Machine Learning · Computer Science 2026-05-04 Junda Ying , Yuxuan Wang , Bowen Yang , Peijie Zhou , Lei Zhang

Many network analysis and graph learning techniques are based on models of random walks which require to infer transition matrices that formalize the underlying stochastic process in an observed graph. For weighted graphs, it is common to…

Methodology · Statistics 2022-10-28 Vincenzo Perri , Luka V. Petrović , Ingo Scholtes

This paper studies the challenging two-view 3D reconstruction in a rigorous sparse-view configuration, which is suffering from insufficient correspondences in the input image pairs for camera pose estimation. We present a novel Neural…

Computer Vision and Pattern Recognition · Computer Science 2023-09-14 Bin Tan , Nan Xue , Tianfu Wu , Gui-Song Xia

Designing a lightweight semantic segmentation network often requires researchers to find a trade-off between performance and speed, which is always empirical due to the limited interpretability of neural networks. In order to release…

Computer Vision and Pattern Recognition · Computer Science 2020-04-02 Peiwen Lin , Peng Sun , Guangliang Cheng , Sirui Xie , Xi Li , Jianping Shi

Vision foundation models trained on discretely sampled images achieve strong performance on classification benchmarks, yet whether their representations encode the continuous processes underlying their training data remains unclear. This…

Computer Vision and Pattern Recognition · Computer Science 2026-01-30 Pritika Vig , Ren-Chin Wu , William Lotter

Many scientific systems, such as cellular populations or economic cohorts, are naturally described by probability distributions that evolve over time. Predicting how such a system would have evolved under different forces or initial…

Machine Learning · Statistics 2026-03-26 Tristan Luca Saidi , Gonzalo Mena , Larry Wasserman , Florian Gunsilius

It is increasingly common to encounter data from dynamic processes captured by static cross-sectional measurements over time, particularly in biomedical settings. Recent attempts to model individual trajectories from this data use optimal…

Machine Learning · Statistics 2020-07-28 Alexander Tong , Jessie Huang , Guy Wolf , David van Dijk , Smita Krishnaswamy

Trajectory inference is a critical problem in single-cell transcriptomics, which aims to reconstruct the dynamic process underlying a population of cells from sequencing data. Of particular interest is the reconstruction of differentiation…

Genomics · Quantitative Biology 2026-04-06 Elodie Maignant , Tim Conrad , Christoph von Tycowicz

Adapting large-scale foundation models to new domains with limited supervision remains a fundamental challenge due to latent distribution mismatch, unstable optimization dynamics, and miscalibrated uncertainty propagation. This paper…

Machine Learning · Computer Science 2026-03-27 Aueaphum Aueawatthanaphisut , Kuepon Auewattanapisut

Fixed representational capacity is a fundamental constraint in continual learning: practitioners must guess an appropriate model width before training, without knowing how many distinct concepts the data contains. We propose LACE…

Machine Learning · Computer Science 2026-03-31 Shivnath Tathe

The ubiquity of dynamic data in domains such as weather, healthcare, and energy underscores a growing need for effective interpretation and retrieval of time-series data. These data are inherently tied to domain-specific contexts, such as…

Machine Learning · Computer Science 2026-02-03 Jialin Chen , Ziyu Zhao , Gaukhar Nurbek , Aosong Feng , Ali Maatouk , Leandros Tassiulas , Yifeng Gao , Rex Ying