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The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to…

Neurons and Cognition · Quantitative Biology 2017-03-03 Jannis Schuecker , Maximilian Schmidt , Sacha J. van Albada , Markus Diesmann , Moritz Helias

Feed-forward neural networks consist of a sequence of layers, in which each layer performs some processing on the information from the previous layer. A downside to this approach is that each layer (or module, as multiple modules can…

Machine Learning · Computer Science 2020-10-19 Alex Lamb , Anirudh Goyal , Agnieszka Słowik , Michael Mozer , Philippe Beaudoin , Yoshua Bengio

Building a humanlike integrative artificial cognitive system, that is, an artificial general intelligence (AGI), is the holy grail of the artificial intelligence (AI) field. Furthermore, a computational model that enables an artificial…

Whole brain segmentation is an important neuroimaging task that segments the whole brain volume into anatomically labeled regions-of-interest. Convolutional neural networks have demonstrated good performance in this task. Existing…

Image and Video Processing · Electrical Eng. & Systems 2021-11-01 Yeshu Li , Jonathan Cui , Yilun Sheng , Xiao Liang , Jingdong Wang , Eric I-Chao Chang , Yan Xu

We present Brain Harmony (BrainHarmonix), the first multimodal brain foundation model that unifies structural morphology and functional dynamics into compact 1D token representations. The model was pretrained on two of the largest…

Due to the widespread use of complex machine learning models in real-world applications, it is becoming critical to explain model predictions. However, these models are typically black-box deep neural networks, explained post-hoc via…

Machine Learning · Computer Science 2022-10-20 Filip Radenovic , Abhimanyu Dubey , Dhruv Mahajan

Brain foundation models have achieved remarkable advances across a wide range of neuroscience tasks. However, most existing models are limited to a single functional modality, restricting their ability to exploit complementary…

Machine Learning · Computer Science 2026-05-18 Hanning Guo , Hanwen Bi , Farah Abdellatif , Andrei Galbenus , Jon. N. Shah , Abigail Morrison , Jürgen Dammers

A fundamental idea in neuroscience is that cognitive functions -- such as perception, learning, memory, and locomotion -- are shaped and constrained by the brain's structural organization. Despite significant progress in mapping and…

Neurons and Cognition · Quantitative Biology 2025-08-07 Elkaïoum M. Moutuou , Habib Benali

The human brain is a complex system, and understanding its mechanisms has been a long-standing challenge in neuroscience. The study of the functional connectome, which maps the functional connections between different brain regions, has…

Neural and Evolutionary Computing · Computer Science 2025-04-14 Tananun Songdechakraiwut , Yutong Wu

Representing dynamical systems through data-driven universal spaces has proven effective; however, achieving this universality for human brain activity remains a significant challenge, further aggravated by diverse cognitive states and…

Quantitative Methods · Quantitative Biology 2026-05-06 Ronghua Zheng , Chengyuan Qian , Weiyang Ding

Recently, there have been several concerted international efforts - the BRAIN initiative, European Human Brain Project and the Human Connectome Project, to name a few - that hope to revolutionize our understanding of the connected brain.…

Neurons and Cognition · Quantitative Biology 2016-02-10 Adeel Razi , Karl Friston

In this paper, we propose a real-world benchmark for studying robotic learning in the context of functional manipulation: a robot needs to accomplish complex long-horizon behaviors by composing individual manipulation skills in functionally…

Robotics · Computer Science 2024-09-04 Jianlan Luo , Charles Xu , Fangchen Liu , Liam Tan , Zipeng Lin , Jeffrey Wu , Pieter Abbeel , Sergey Levine

Despite the recent success of neural network models in mimicking animal performance on visual perceptual tasks, critics worry that these models fail to illuminate brain function. We take it that a central approach to explanation in systems…

Neurons and Cognition · Quantitative Biology 2021-04-13 Rosa Cao , Daniel Yamins

Deciphering brain function through non-invasive recordings requires synthesizing complementary high-frequency electromagnetic (EEG/MEG) and low-frequency metabolic (fMRI) signals. However, despite their shared neural origins, extreme…

Neurons and Cognition · Quantitative Biology 2026-02-26 Changli Tang , Shurui Li , Junliang Wang , Qinfan Xiao , Zhonghao Zhai , Lei Bai , Yu Qiao , Bowen Zhou , Wen Wu , Yuanning Li , Chao Zhang

Deep Feedback Models (DFMs) are a new class of stateful neural networks that combine bottom up input with high level representations over time. This feedback mechanism introduces dynamics into otherwise static architectures, enabling DFMs…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 David Calhas , Arlindo L. Oliveira

Whole-brain network analyses remain the vanguard in neuroimaging research, coming to prominence within the last decade. Network science approaches have facilitated these analyses and allowed examining the brain as an integrated system.…

Applications · Statistics 2015-05-04 Sean L. Simpson , Paul J. Laurienti

Recent advances in multimodal large language models (LLMs) have enabled unified reasoning across images, audio, and video, but extending such capability to brain imaging remains largely unexplored. Bridging this gap is essential to link…

Computation and Language · Computer Science 2026-05-15 Yuxiang Wei , Yanteng Zhang , Xi Xiao , Chengxuan Qian , Tianyang Wang , Vince D. Calhoun

Magnetic resonance imaging~(MRI) have played a crucial role in brain disease diagnosis, with which a range of computer-aided artificial intelligence methods have been proposed. However, the early explorations usually focus on the limited…

Computer Vision and Pattern Recognition · Computer Science 2023-09-14 Jiayu Lei , Lisong Dai , Haoyun Jiang , Chaoyi Wu , Xiaoman Zhang , Yao Zhang , Jiangchao Yao , Weidi Xie , Yanyong Zhang , Yuehua Li , Ya Zhang , Yanfeng Wang

An unprecedented amount of existing functional Magnetic Resonance Imaging (fMRI) data provides a new opportunity to understand the relationship between functional fluctuation and human cognition/behavior using a data-driven approach. To…

Machine Learning · Computer Science 2024-09-18 Jiaqi Ding , Tingting Dan , Ziquan Wei , Hyuna Cho , Paul J. Laurienti , Won Hwa Kim , Guorong Wu

Multimodal foundation models that can holistically process text alongside images, video, audio, and other sensory modalities are increasingly used in a variety of real-world applications. However, it is challenging to characterize and study…