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Methods for out-of-distribution (OOD) detection that scale to 3D data are crucial components of any real-world clinical deep learning system. Classic denoising diffusion probabilistic models (DDPMs) have been recently proposed as a robust…

Deep learning systems deployed in real-world applications often encounter data that is different from their in-distribution (ID). A reliable model should ideally abstain from making decisions in this out-of-distribution (OOD) setting.…

Machine Learning · Computer Science 2025-10-02 Berker Demirel , Marco Fumero , Francesco Locatello

A crucial requirement for machine learning algorithms is not only to perform well, but also to show robustness and adaptability when encountering novel scenarios. One way to achieve these characteristics is to endow the deep learning models…

Computer Vision and Pattern Recognition · Computer Science 2025-02-26 Eduardo Aguilar , Bogdan Raducanu , Petia Radeva

Out-of-Distribution (OOD) detection under long-tailed distributions is a highly challenging task because the scarcity of samples in tail classes leads to blurred decision boundaries in the feature space. Current state-of-the-art (sota)…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Ningkang Peng , Qianfeng Yu , Yuhao Zhang , Yafei Liu , Xiaoqian Peng , Peirong Ma , Yi Chen , Peiheng Li , Yanhui Gu

The complex and dynamic real-world clinical environment demands reliable deep learning (DL) systems. Out-of-distribution (OOD) detection plays a critical role in enhancing the reliability and generalizability of DL models when encountering…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Jiangbei Yue , Darren Treanor , Venkataraman Subramanian , Sharib Ali

Deep Learning (DL) models tend to perform poorly when the data comes from a distribution different from the training one. In critical applications such as medical imaging, out-of-distribution (OOD) detection helps to identify such data…

Image and Video Processing · Electrical Eng. & Systems 2023-06-26 Daria Frolova , Anton Vasiliuk , Mikhail Belyaev , Boris Shirokikh

Safety measures need to be systemically investigated to what extent they evaluate the intended performance of Deep Neural Networks (DNNs) for critical applications. Due to a lack of verification methods for high-dimensional DNNs, a…

Machine Learning · Computer Science 2024-01-31 Jens Henriksson , Christian Berger , Stig Ursing , Markus Borg

Clinically deployed deep learning-based segmentation models are known to fail on data outside of their training distributions. While clinicians review the segmentations, these models tend to perform well in most instances, which could…

Recent large vision-language models such as CLIP have shown remarkable out-of-distribution (OOD) detection and generalization performance. However, their zero-shot in-distribution (ID) accuracy is often limited for downstream datasets.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-30 Yifei Ming , Yixuan Li

Out-of-distribution (OOD) detection is essential for reliably deploying machine learning models in the wild. Yet, most methods treat large pre-trained models as monolithic encoders and rely solely on their final-layer representations for…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 I. M. De la Jara , C. Rodriguez-Opazo , D. Teney , D. Ranasinghe , E. Abbasnejad

Detecting out-of-distribution (OOD) inputs is a critical safeguard for deploying machine learning models in the real world. However, most post-hoc detection methods operate on penultimate feature representations derived from global average…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Abid Hassan , Tuan Ngo , Saad Shafiq , Nenad Medvidovic

For a machine learning model deployed in real world scenarios, the ability of detecting out-of-distribution (OOD) samples is indispensable and challenging. Most existing OOD detection methods focused on exploring advanced training skills or…

Machine Learning · Computer Science 2024-02-16 Chao Chen , Zhihang Fu , Kai Liu , Ze Chen , Mingyuan Tao , Jieping Ye

Out-of-distribution (OOD) detection aims to identify test examples that do not belong to the training distribution and are thus unlikely to be predicted reliably. Despite a plethora of existing works, most of them focused only on the…

Machine Learning · Computer Science 2023-11-07 Reza Averly , Wei-Lun Chao

Purpose: A fundamental problem in designing safe machine learning systems is identifying when samples presented to a deployed model differ from those observed at training time. Detecting so-called out-of-distribution (OoD) samples is…

Computer Vision and Pattern Recognition · Computer Science 2023-05-04 Alain Jungo , Lars Doorenbos , Tommaso Da Col , Maarten Beelen , Martin Zinkernagel , Pablo Márquez-Neila , Raphael Sznitman

Predictive machine learning models generally excel on in-distribution data, but their performance degrades on out-of-distribution (OOD) inputs. Reliable deployment therefore requires robust OOD detection, yet this is particularly…

Machine Learning · Computer Science 2026-02-19 David Graber , Victor Armegioiu , Rebecca Buller , Siddhartha Mishra

Detecting out-of-distribution (OOD) data is crucial for ensuring the safe deployment of machine learning models in real-world applications. However, existing OOD detection approaches primarily rely on the feature maps or the full gradient…

Computer Vision and Pattern Recognition · Computer Science 2023-08-02 Sima Behpour , Thang Doan , Xin Li , Wenbin He , Liang Gou , Liu Ren

The capacity of a modern deep learning system to determine if a sample falls within its realm of knowledge is fundamental and important. In this paper, we offer insights and analyses of recent state-of-the-art out-of-distribution (OOD)…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Kai Xu , Rongyu Chen , Gianni Franchi , Angela Yao

Out-of-distribution (OOD) detection is crucial to modern deep learning applications by identifying and alerting about the OOD samples that should not be tested or used for making predictions. Current OOD detection methods have made…

Machine Learning · Computer Science 2023-09-22 Xinheng Wu , Jie Lu , Zhen Fang , Guangquan Zhang

Out-of-distribution detection is an important capability that has long eluded vanilla neural networks. Deep Neural networks (DNNs) tend to generate over-confident predictions when presented with inputs that are significantly…

Machine Learning · Computer Science 2022-02-24 Sumedh A Sontakke , Buvaneswari Ramanan , Laurent Itti , Thomas Woo

Deep learning models are vulnerable to performance degradation when encountering out-of-distribution (OOD) images, potentially leading to misdiagnoses and compromised patient care. These shortcomings have led to great interest in the field…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Lars Doorenbos , Raphael Sznitman , Pablo Márquez-Neila