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High-performing medical Large Language Models (LLMs) typically require extensive fine-tuning with substantial computational resources, limiting accessibility for resource-constrained healthcare institutions. This study introduces a…

Computation and Language · Computer Science 2025-10-17 Ziad Elshaer , Essam A. Rashed

The growing use of large language models (LLMs) for biomedical question answering raises concerns about the accuracy and evidentiary support of their responses. To address this, we present Answered with Evidence, a framework for evaluating…

Machine Learning · Computer Science 2025-07-08 Julian D Baldwin , Christina Dinh , Arjun Mukerji , Neil Sanghavi , Saurabh Gombar

One problem to solve in the context of information fusion, decision-making, and other artificial intelligence challenges is to compute justified beliefs based on evidence. In real-life examples, this evidence may be inconsistent,…

Artificial Intelligence · Computer Science 2023-06-07 Daira Pinto Prieto , Ronald de Haan , Aybüke Özgün

The paper introduces a framework for the evaluation of the encoding of factual scientific knowledge, designed to streamline the manual evaluation process typically conducted by domain experts. Inferring over and extracting information from…

Computation and Language · Computer Science 2024-10-21 Magdalena Wysocka , Oskar Wysocki , Maxime Delmas , Vincent Mutel , Andre Freitas

Medical question-answering (QA) is a critical task for evaluating how effectively large language models (LLMs) encode clinical knowledge and assessing their potential applications in medicine. Despite showing promise on multiple-choice…

Computation and Language · Computer Science 2025-03-06 Guangfu Guo , Kai Zhang , Bryan Hoo , Yujun Cai , Xiaoqian Lu , Nanyun Peng , Yiwei Wang

Biomedical question answering (QA) requires accurate interpretation of complex medical knowledge. Large language models (LLMs) have shown promising capabilities in this domain, with retrieval-augmented generation (RAG) systems enhancing…

Computation and Language · Computer Science 2025-10-21 Yingpeng Ning , Yuanyuan Sun , Ling Luo , Yanhua Wang , Yuchen Pan , Hongfei Lin

Large-scale language models (LLMs) often offer clinical judgments based on incomplete information, increasing the risk of misdiagnosis. Existing studies have primarily evaluated confidence in single-turn, static settings, overlooking the…

Computation and Language · Computer Science 2026-01-23 Zhiyao Ren , Yibing Zhan , Siyuan Liang , Guozheng Ma , Baosheng Yu , Dacheng Tao

Language models often struggle with handling factual knowledge, exhibiting factual hallucination issue. This makes it vital to evaluate the models' ability to recall its parametric knowledge about facts. In this study, we introduce a…

Computation and Language · Computer Science 2024-10-10 Xin Zhao , Naoki Yoshinaga , Daisuke Oba

Biomedical retrieval-augmented large language models (LLMs) often face evidence that is incomplete, misleading, or internally contradictory, yet evaluation usually emphasizes answer accuracy under helpful context rather than reliability…

Computation and Language · Computer Science 2026-05-15 Yikun Han , Mengfei Lan , Halil Kilicoglu

Scientific documents contain complex multimodal structures, which makes evidence localization and scientific reasoning in Document Visual Question Answering particularly challenging. However, most existing benchmarks evaluate models only at…

Databases · Computer Science 2026-03-31 Wenhan Yu , Zhaoxi Zhang , Wang Chen , Guanqiang Qi , Weikang Li , Lei Sha , Deguo Xia , Jizhou Huang

Biomedical entity linking maps textual mentions to concepts in structured knowledge bases such as UMLS or SNOMED CT. Most existing systems link each mention independently, using only the mention or its surrounding sentence. This ignores…

Computation and Language · Computer Science 2026-05-14 Adam Remaki , Xavier Tannier , Christel Gérardin

When addressing professional questions in the biomedical domain, humans typically acquire multiple pieces of information as evidence and engage in multifaceted analysis to provide high-quality answers. Current LLM-based question answering…

Computation and Language · Computer Science 2025-09-03 Chang Zong , Jian Wan , Siliang Tang , Lei Zhang

Open-ended question answering requires models to find appropriate evidence to form wellreasoned, comprehensive and helpful answers. In practical applications, models also need to engage in extended discussions on potential scenarios closely…

Computation and Language · Computer Science 2024-12-17 Mingxu Tao , Dongyan Zhao , Yansong Feng

While large language models (LLMs) are proficient at question-answering (QA), it is not always clear how (or even if) an answer follows from their latent "beliefs". This lack of interpretability is a growing impediment to widespread use of…

Computation and Language · Computer Science 2023-10-31 Nora Kassner , Oyvind Tafjord , Ashish Sabharwal , Kyle Richardson , Hinrich Schuetze , Peter Clark

Although biomedical entity linking (BioEL) has made significant progress with pre-trained language models, challenges still exist for fine-grained and long-tailed entities. To address these challenges, we present BioELQA, a novel model that…

Computation and Language · Computer Science 2024-05-20 Zhenxi Lin , Ziheng Zhang , Xian Wu , Yefeng Zheng

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

We introduce a framework for the use of large language models (LLMs) in Building Understandable Messaging for Policy and Evidence Review (BUMPER). LLMs are proving capable of providing interfaces for understanding and synthesizing large…

Computation and Language · Computer Science 2024-07-19 Katherine A. Rosenfeld , Maike Sonnewald , Sonia J. Jindal , Kevin A. McCarthy , Joshua L. Proctor

Despite the dramatic progress in Large Language Model (LLM) development, LLMs often provide seemingly plausible but not factual information, often referred to as hallucinations. Retrieval-augmented LLMs provide a non-parametric approach to…

Computation and Language · Computer Science 2023-11-09 Sai Munikoti , Anurag Acharya , Sridevi Wagle , Sameera Horawalavithana

This work proposes an evidence-retrieval mechanism for uncertainty-aware decision-making that replaces a single global cutoff with an evidence-conditioned, instance-adaptive criterion. For each test instance, proximal exemplars are…

Computer Vision and Pattern Recognition · Computer Science 2025-09-18 Hassan Gharoun , Mohammad Sadegh Khorshidi , Kasra Ranjbarigderi , Fang Chen , Amir H. Gandomi

Large language models (LLMs) are increasingly deployed in domains where errors carry high social, scientific, or safety costs. Yet standard confidence estimators, such as token likelihood, semantic similarity and multi-sample consistency,…

Computation and Language · Computer Science 2026-02-03 Pengyue Yang , Jiawen Wen , Haolin Jin , Linghan Huang , Huaming Chen , Ling Chen
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