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Large language models (LLMs) have significantly advanced dialogue systems and role-playing agents through their ability to generate human-like text. While prior studies have shown that LLMs can exhibit distinct and consistent personalities,…

Computation and Language · Computer Science 2025-02-18 Shu Yang , Shenzhe Zhu , Liang Liu , Lijie Hu , Mengdi Li , Di Wang

Recent breakthroughs in large language models (LLMs) offer unprecedented natural language understanding and generation capabilities. However, existing surveys on LLMs in biomedicine often focus on specific applications or model…

The pursuit of leaderboard rankings in Large Language Models (LLMs) has created a fundamental paradox: models excel at standardized tests while failing to demonstrate genuine language understanding and adaptability. Our systematic analysis…

Computation and Language · Computer Science 2024-12-06 Sourav Banerjee , Ayushi Agarwal , Eishkaran Singh

Large language models (LLMs) have been applied to tasks in healthcare, ranging from medical exam questions to responding to patient questions. With increasing institutional partnerships between companies producing LLMs and healthcare…

Computation and Language · Computer Science 2024-04-10 Jesutofunmi A. Omiye , Haiwen Gui , Shawheen J. Rezaei , James Zou , Roxana Daneshjou

Background: Cognitive biases in clinical decision-making significantly contribute to errors in diagnosis and suboptimal patient outcomes. Addressing these biases presents a formidable challenge in the medical field. Objective: This study…

Computation and Language · Computer Science 2024-05-14 Yu He Ke , Rui Yang , Sui An Lie , Taylor Xin Yi Lim , Hairil Rizal Abdullah , Daniel Shu Wei Ting , Nan Liu

Large Language Models (LLMs) have significantly advanced natural language processing applications, yet their widespread use raises concerns regarding inherent biases that may reduce utility or harm for particular social groups. Despite the…

Computers and Society · Computer Science 2025-02-05 Bo Pang , Tingrui Qiao , Caroline Walker , Chris Cunningham , Yun Sing Koh

Clinical trial matching is a key process in health delivery and discovery. In practice, it is plagued by overwhelming unstructured data and unscalable manual processing. In this paper, we conduct a systematic study on scaling clinical trial…

Recent literature has suggested the potential of using large language models (LLMs) to make classifications for tabular tasks. However, LLMs have been shown to exhibit harmful social biases that reflect the stereotypes and inequalities…

Computation and Language · Computer Science 2024-04-04 Yanchen Liu , Srishti Gautam , Jiaqi Ma , Himabindu Lakkaraju

Large language models (LLMs) have emerged as powerful tools with transformative potential across numerous domains, including healthcare and medicine. In the medical domain, LLMs hold promise for tasks ranging from clinical decision support…

Computation and Language · Computer Science 2024-05-14 Xiaolan Chen , Jiayang Xiang , Shanfu Lu , Yexin Liu , Mingguang He , Danli Shi

Large language models (LLMs) show promise in drafting responses to patient portal messages, yet their integration into clinical workflows raises various concerns, including whether they would actually save clinicians time and effort in…

Computation and Language · Computer Science 2026-01-19 Parker Seegmiller , Joseph Gatto , Sarah E. Greer , Ganza Belise Isingizwe , Rohan Ray , Timothy E. Burdick , Sarah Masud Preum

Frontier Large Language Models (LLMs) can be socially discriminatory or sensitive to spurious features of their inputs. Because only well-resourced corporations can train frontier LLMs, we need robust test-time strategies to control such…

Computation and Language · Computer Science 2024-10-08 Leonardo Cotta , Chris J. Maddison

Substance use disorder (SUD) poses a major concern due to its detrimental effects on health and society. SUD identification and treatment depend on a variety of factors such as severity, co-determinants (e.g., withdrawal symptoms), and…

Computation and Language · Computer Science 2024-03-20 Maria Mahbub , Gregory M. Dams , Sudarshan Srinivasan , Caitlin Rizy , Ioana Danciu , Jodie Trafton , Kathryn Knight

Large Language Models (LLMs) have demonstrated impressive capabilities in role-playing scenarios, particularly in simulating domain-specific experts using tailored prompts. This ability enables LLMs to adopt the persona of individuals with…

Artificial Intelligence · Computer Science 2025-01-14 Xinyao Ma , Rui Zhu , Zihao Wang , Jingwei Xiong , Qingyu Chen , Haixu Tang , L. Jean Camp , Lucila Ohno-Machado

Large language models (LLMs) are increasingly used in domains where causal reasoning matters, yet it remains unclear whether their judgments reflect normative causal computation, human-like shortcuts, or brittle pattern matching. We…

Artificial Intelligence · Computer Science 2026-03-16 Hanna M. Dettki , Charley M. Wu , Bob Rehder

The validity of medical studies based on real-world clinical data, such as observational studies, depends on critical assumptions necessary for drawing causal conclusions about medical interventions. Many published studies are flawed…

Artificial Intelligence · Computer Science 2024-07-30 Ahmed Alaa , Rachael V. Phillips , Emre Kıcıman , Laura B. Balzer , Mark van der Laan , Maya Petersen

As Large Language Models (LLMs) are increasingly integrated into healthcare to address complex inquiries, ensuring their reliability remains a critical challenge. Recent studies have highlighted that generic LLMs often struggle in clinical…

Computation and Language · Computer Science 2026-04-01 Bian Sun , Zhenjian Wang , Orvill de la Torre , Zirui Wang

Large language models (LLMs) are increasingly deployed in settings where inducing a bias toward a certain topic can have significant consequences, and backdoor attacks can be used to produce such models. Prior work on backdoor attacks has…

Cryptography and Security · Computer Science 2026-02-17 Anudeep Das , Prach Chantasantitam , Gurjot Singh , Lipeng He , Mariia Ponomarenko , Florian Kerschbaum

Large Language Models (LLMs) have great potential in the field of health care, yet they face great challenges in adapting to rapidly evolving medical knowledge. This can lead to outdated or contradictory treatment suggestions. This study…

Computation and Language · Computer Science 2025-09-09 Weiyi Wu , Xinwen Xu , Chongyang Gao , Xingjian Diao , Siting Li , Lucas A. Salas , Jiang Gui

This position paper's primary goal is to provoke thoughtful discussion about the relationship between bias and fundamental properties of large language models. I do this by seeking to convince the reader that harmful biases are an…

Computation and Language · Computer Science 2025-03-17 Philip Resnik

Recently, Large Language Models (LLMs) have demonstrated a superior ability to serve as ranking models. However, concerns have arisen as LLMs will exhibit discriminatory ranking behaviors based on users' sensitive attributes (\eg gender).…

Information Retrieval · Computer Science 2024-09-26 Chen Xu , Wenjie Wang , Yuxin Li , Liang Pang , Jun Xu , Tat-Seng Chua
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