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We propose to use Bayesian optimization (BO) to improve the efficiency of the design selection process in clinical trials. BO is a method to optimize expensive black-box functions, by using a regression as a surrogate to guide the search.…

Methodology · Statistics 2021-05-20 Jakob Richter , Tim Friede , Jörg Rahnenführer

Multi-modal Large Language Models (MLLMs) have exhibited impressive capability. However, recently many deficiencies of MLLMs have been found compared to human intelligence, $\textit{e.g.}$, hallucination. To drive the MLLMs study, the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Hong Li , Nanxi Li , Yuanjie Chen , Jianbin Zhu , Qinlu Guo , Cewu Lu , Yong-Lu Li

Benchmark suites, i.e. a collection of benchmark functions, are widely used in the comparison of black-box optimization algorithms. Over the years, research has identified many desired qualities for benchmark suites, such as diverse…

Neural and Evolutionary Computing · Computer Science 2021-04-16 David Issa Mattos , Lucas Ruud , Jan Bosch , Helena Holmström Olsson

Bayesian optimization (BO) is well known to be sample-efficient for solving black-box problems. However, the BO algorithms can sometimes get stuck in suboptimal solutions even with plenty of samples. Intrinsically, such suboptimal problem…

Machine Learning · Computer Science 2025-01-24 Zhendong Guo , Yew-Soon Ong , Tiantian He , Haitao Liu

Bayesian optimization (BO) is a well-established method to optimize black-box functions whose direct evaluations are costly. In this paper, we tackle the problem of incorporating expert knowledge into BO, with the goal of further…

Machine Learning · Computer Science 2022-08-19 Daolang Huang , Louis Filstroff , Petrus Mikkola , Runkai Zheng , Samuel Kaski

Bayesian optimization (BO) has gained attention as an efficient algorithm for black-box optimization of expensive-to-evaluate systems, where the BO algorithm iteratively queries the system and suggests new trials based on a probabilistic…

Machine Learning · Computer Science 2026-03-13 Eike Cramer , Luis Kutschat , Oliver Stollenwerk , Joel A. Paulson , Alexander Mitsos

Large Language Models (LLMs) have become extremely potent instruments with exceptional capacities for comprehending and producing human-like text in a wide range of applications. However, the increasing size and complexity of LLMs present…

Machine Learning · Computer Science 2024-06-18 Yingbing Huang , Lily Jiaxin Wan , Hanchen Ye , Manvi Jha , Jinghua Wang , Yuhong Li , Xiaofan Zhang , Deming Chen

Bayesian optimization (BO) is a popular paradigm for global optimization of expensive black-box functions, but there are many domains where the function is not completely a black-box. The data may have some known structure (e.g. symmetries)…

Machine Learning · Computer Science 2022-12-08 Samuel Kim , Peter Y. Lu , Charlotte Loh , Jamie Smith , Jasper Snoek , Marin Soljačić

Tool learning has generated widespread interest as a vital means of interaction between Large Language Models (LLMs) and the physical world. Current research predominantly emphasizes LLMs' capacity to utilize tools in well-structured…

Computation and Language · Computer Science 2024-09-24 Junjie Ye , Yilong Wu , Songyang Gao , Caishuang Huang , Sixian Li , Guanyu Li , Xiaoran Fan , Qi Zhang , Tao Gui , Xuanjing Huang

Optimisation problems often have multiple conflicting objectives that can be computationally and/or financially expensive. Mono-surrogate Bayesian optimisation (BO) is a popular model-based approach for optimising such black-box functions.…

Machine Learning · Computer Science 2022-08-11 George De Ath , Tinkle Chugh , Alma A. M. Rahat

Bayesian optimization (BO) has emerged during the last few years as an effective approach to optimizing black-box functions where direct queries of the objective are expensive. In this paper we consider the case where direct access to the…

Machine Learning · Statistics 2017-04-13 Javier Gonzalez , Zhenwen Dai , Andreas Damianou , Neil D. Lawrence

The rapid progress of artificial intelligence increasingly relies on efficient integrated circuit (IC) design. Recent studies have explored the use of large language models (LLMs) for generating Register Transfer Level (RTL) code, but…

Artificial Intelligence · Computer Science 2026-01-06 Yao Lu , Shang Liu , Hangan Zhou , Wenji Fang , Qijun Zhang , Zhiyao Xie

A plethora of applications entail solving black-box optimization problems with high evaluation costs, including drug discovery, material design, as well as hyperparameter tuning. Toward finding the global optimum of such black-box…

Machine Learning · Computer Science 2025-10-06 Haotian Xiang , Jinwen Xu , Qin Lu

Deployments of Bayesian Optimization (BO) for functions with stochastic evaluations, such as parameter tuning via cross validation and simulation optimization, typically optimize an average of a fixed set of noisy realizations of the…

Machine Learning · Computer Science 2020-07-03 Henry B. Moss , David S. Leslie , Paul Rayson

Weight binarization has emerged as a promising strategy to reduce the complexity of large language models (LLMs). Existing approaches fall into post-training binarization, which is simple but causes severe performance loss, and…

Machine Learning · Statistics 2026-04-22 Ba-Hien Tran , Van Minh Nguyen

Bayesian Optimization (BO) is a standard tool for hyperparameter tuning thanks to its sample efficiency on expensive black-box functions. While most BO pipelines begin with uniform random initialization, default hyperparameter values…

Machine Learning · Computer Science 2026-02-10 Nicolás Villagrán Prieto , Eduardo C. Garrido-Merchán

Optimization modeling plays a critical role in the application of Operations Research (OR) tools to address real-world problems, yet they pose challenges and require extensive expertise from OR experts. With the advent of large language…

Computation and Language · Computer Science 2025-07-30 Chenyu Huang , Zhengyang Tang , Shixi Hu , Ruoqing Jiang , Xin Zheng , Dongdong Ge , Benyou Wang , Zizhuo Wang

With advances in scientific computing, computer experiments are increasingly used for optimizing complex systems. However, for modern applications, e.g., the optimization of nuclear physics detectors, each experiment run can require…

Machine Learning · Statistics 2025-08-08 Hwanwoo Kim , Simon Mak , Ann-Kathrin Schuetz , Alan Poon

Large Language Models (LLMs) are increasingly deployed in real-world applications that demand complex reasoning. To track progress, robust benchmarks are required to evaluate their capabilities beyond superficial pattern recognition.…

Computation and Language · Computer Science 2025-06-03 Wenye Lin , Jonathan Roberts , Yunhan Yang , Samuel Albanie , Zongqing Lu , Kai Han

Machine learning algorithms for generating molecular structures offer a promising new approach to drug discovery. We cast molecular optimization as a translation problem, where the goal is to map an input compound to a target compound with…

Machine Learning · Computer Science 2019-12-24 Farhan Damani , Vishnu Sresht , Stephen Ra
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