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Stroke affected millions annually, yet poor symptom recognition often delayed care-seeking. To address risk recognition gap, we developed a passive surveillance system for early stroke risk detection using patient-reported symptoms among…

Accurate preoperative prediction of erectile dysfunction (ED) is important for counseling patients undergoing radical prostatectomy. While clinical features are established predictors, the added value of preoperative MRI remains…

Public datasets of Chest X-Rays (CXRs) have long been a popular benchmark for developing machine learning (ML) computer vision models in healthcare. However, the reported strong average-case performance of these models do not necessarily…

Machine Learning · Computer Science 2026-02-10 Andrew Wang , Jiashuo Zhang , Michael Oberst

Machine learning (ML) models may suffer from significant performance disparities between patient groups. Identifying such disparities by monitoring performance at a granular level is crucial for safely deploying ML to each patient.…

Machine Learning · Computer Science 2025-03-14 Alceu Bissoto , Trung-Dung Hoang , Tim Flühmann , Susu Sun , Christian F. Baumgartner , Lisa M. Koch

While machine learning (ML) includes a valuable array of tools for analyzing biomedical data, significant time and expertise is required to assemble effective, rigorous, and unbiased pipelines. Automated ML (AutoML) tools seek to facilitate…

Covariate adjustment is widely recommended to improve statistical efficiency in randomized clinical trials (RCTs), yet empirical evidence comparing available strategies remains limited. This lack of real-world evaluation leaves unresolved…

Applications · Statistics 2026-02-03 Yulin Shao , Liangbo Lyu , Menggang Yu , Bingkai Wang

Urinary tract infection (UTI) flare-ups pose a significant health risk for older adults with chronic conditions. These infections often go unnoticed until they become severe, making early detection through innovative smart home technologies…

Machine Learning · Computer Science 2025-11-25 Chibuike E. Ugwu , Roschelle Fritz , Diane J. Cook , Janardhan Rao Doppa

Many existing models for clinical trial outcome prediction are optimized using task-specific loss functions on trial phase-specific data. While this scheme may boost prediction for common diseases and drugs, it can hinder learning of…

Machine Learning · Computer Science 2025-05-27 Yiqing Zhang , Xiaozhong Liu , Fabricio Murai

Lower urinary tract symptoms (LUTS) can indicate the presence of urinary tract infection (UTI), a condition that if it becomes chronic requires expensive and time consuming care as well as leading to reduced quality of life. Detecting the…

Applications · Statistics 2015-07-13 William Barcella , Maria De Iorio , Gianluca Baio , James Malone-Lee

Morphological analysis of longitudinal MR images plays a key role in monitoring disease progression for prostate cancer patients, who are placed under an active surveillance program. In this paper, we describe a learning-based image…

Image and Video Processing · Electrical Eng. & Systems 2020-11-05 Qianye Yang , Yunguan Fu , Francesco Giganti , Nooshin Ghavami , Qingchao Chen , J. Alison Noble , Tom Vercauteren , Dean Barratt , Yipeng Hu

Mammography, an X-ray-based imaging technique, remains central to the early detection of breast cancer. Recent advances in artificial intelligence have enabled increasingly sophisticated computer-aided diagnostic methods, evolving from…

Image and Video Processing · Electrical Eng. & Systems 2025-10-09 Daniel G. P. Petrini , Hae Yong Kim

Recent genome-wide association studies (GWAS) have uncovered the genetic basis of complex traits, but show an under-representation of non-European descent individuals, underscoring a critical gap in genetic research. Here, we assess whether…

Machine Learning · Computer Science 2024-05-08 Thomas Le Menestrel , Erin Craig , Robert Tibshirani , Trevor Hastie , Manuel Rivas

Kidney stones are a common and debilitating health issue, and genetic factors play a crucial role in determining susceptibility. While Genome-Wide Association Studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs)…

Genomics · Quantitative Biology 2024-12-24 Amr Salem , Anirban Mondal

Purpose; The purpose of this study is to classify glial tumors into grade II, III and IV categories noninvasively by application of machine learning to multi-modal MRI features in comparison with volumetric analysis. Methods; We…

Image and Video Processing · Electrical Eng. & Systems 2022-08-16 Sevcan Turk , Kaya Oguz , Mehmet Orman , Emre Caliskan , Yesim Ertan , Erkin Ozgiray , Taner Akalin , Ashok Srinivasan , Omer Kitis

Prostate cancer (PCa) poses a significant threat to men's health, with early diagnosis being crucial for improving prognosis and reducing mortality rates. Transrectal ultrasound (TRUS) plays a vital role in the diagnosis and image-guided…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Haiqiao Wang , Hong Wu , Zhuoyuan Wang , Peiyan Yue , Dong Ni , Pheng-Ann Heng , Yi Wang

Biosecurity risk material (BRM) presents a clear and significant threat to national and international environmental and economic assets. Intercepting BRM carried by non-compliant international passengers is a key priority of border…

Applications · Statistics 2017-02-15 Stephen E Lane , Richard Gao , Matthew Chisholm , Andrew P Robinson

Risk stratification (characterization) of tumors from radiology images can be more accurate and faster with computer-aided diagnosis (CAD) tools. Tumor characterization through such tools can also enable non-invasive cancer staging,…

Computer Vision and Pattern Recognition · Computer Science 2019-01-21 Sarfaraz Hussein , Pujan Kandel , Candice W. Bolan , Michael B. Wallace , Ulas Bagci

Intracerebral hemorrhage (ICH) is a life-risking condition characterized by bleeding within the brain parenchyma. ICU readmission in ICH patients is a critical outcome, reflecting both clinical severity and resource utilization. Accurate…

Machine Learning · Computer Science 2025-01-03 Shuheng Chen , Junyi Fan , Armin Abdollahi , Negin Ashrafi , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Background: The rapid advancement of Machine Learning (ML) represents novel opportunities to enhance public health research, surveillance, and decision-making. However, there is a lack of comprehensive understanding of algorithmic bias,…

Machine Learning · Computer Science 2024-09-04 Shaina Raza , Arash Shaban-Nejad , Elham Dolatabadi , Hiroshi Mamiya

Unsupervised patient stratification is essential for disease subtype discovery, yet, despite growing evidence of molecular heterogeneity of non-oncological diseases, popular methods are benchmarked primarily using cancers with mutually…

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