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Patients are increasingly turning to large language models (LLMs) with medical questions that are complex and difficult to articulate clearly. However, LLMs are sensitive to prompt phrasings and can be influenced by the way questions are…

Large language models (LLMs) show promise for supporting clinicians in diagnostic communication by generating explanations and guidance for patients. Yet their ability to produce outputs that are both understandable and empathetic remains…

The paper introduces a framework for the evaluation of the encoding of factual scientific knowledge, designed to streamline the manual evaluation process typically conducted by domain experts. Inferring over and extracting information from…

Large language models (LLMs) pose significant risks due to the potential for generating harmful content or users attempting to evade guardrails. Existing studies have developed LLM-based guard models designed to moderate the input and…

Although large language models (LLMs) store vast amount of knowledge in their parameters, they still have limitations in the memorization and utilization of certain knowledge, leading to undesired behaviors such as generating untruthful and…

While state-of-the-art large language models (LLMs) demonstrate advanced reasoning capabilities-achieving remarkable performance on challenging competitive math and coding benchmarks-they also frequently fail on tasks that are easy for…

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

Recent advances in Large Language Models (LLMs) highlight the need to align their behaviors with human values. A critical, yet understudied, issue is the potential divergence between an LLM's stated preferences (its reported alignment with…

Large language models (LLMs) are currently being used to answer medical questions across a variety of clinical domains. Recent top-performing commercial LLMs, in particular, are also capable of citing sources to support their responses. In…

Large language models (LLMs) are routinely used by physicians and patients for medical advice, yet their clinical safety profiles remain poorly characterized. We present NOHARM (Numerous Options Harm Assessment for Risk in Medicine), a…

The evaluation of Large Language Models (LLMs) in healthcare has been dominated by physician-centric, English-language benchmarks, creating a dangerous illusion of competence that ignores the interprofessional nature of patient care. To…

Multimodal large language models (MLLMs) have recently achieved state-of-the-art performance on tasks ranging from visual question answering to video understanding. However, existing studies have concentrated mainly on visual-textual…

Large Language Models (LLMs) are acquiring a wider range of capabilities, including understanding and responding in multiple languages. While they undergo safety training to prevent them from answering illegal questions, imbalances in…

Large Language Models (LLMs) are pretrained on textual data up to a specific temporal cutoff. This creates a strict knowledge boundary beyond which models cannot provide accurate information without querying external sources. More subtly,…

This study evaluates the capacity of large language models (LLMs) to generate structured clinical consultation templates for electronic consultation. Using 145 expert-crafted templates developed and routinely used by Stanford's eConsult…

Concerns with the safety and reliability of applying large-language models (LLMs) in unpredictable real-world applications motivate this study, which examines how task phrasing can lead to presumptions in LLMs, making it difficult for them…

In high-stakes domains like medicine, it may be generally desirable for models to faithfully adhere to the context provided. But what happens if the context does not align with model priors or safety protocols? In this paper, we investigate…

As qualitative researchers show growing interest in using automated tools to support interpretive analysis, a large language model (LLM) is often introduced into an analytic workflow as is, without systematic evaluation of interpretive…

Large Language Models (LLMs) show remarkable proficiency in natural language tasks, yet their frequent overconfidence-misalignment between predicted confidence and true correctness-poses significant risks in critical decision-making…

The application of large language models (LLMs) in healthcare holds significant promise for enhancing clinical decision-making, medical research, and patient care. However, their integration into real-world clinical settings raises critical…