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Safety alignment in Large Language Models is critical for healthcare; however, reliance on binary refusal boundaries often results in \emph{over-refusal} of benign queries or \emph{unsafe compliance} with harmful ones. While existing…

Artificial Intelligence · Computer Science 2026-01-27 Zhihao Zhang , Liting Huang , Guanghao Wu , Preslav Nakov , Heng Ji , Usman Naseem

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge…

The evaluation and improvement of medical large language models (LLMs) are critical for their real-world deployment, particularly in ensuring accuracy, safety, and ethical alignment. Existing frameworks inadequately dissect domain-specific…

Computation and Language · Computer Science 2025-03-11 Luyi Jiang , Jiayuan Chen , Lu Lu , Xinwei Peng , Lihao Liu , Junjun He , Jie Xu

People increasingly turn to large language models (LLMs) to interpret ambiguous social situations: a delayed text reply, an unusually cold supervisor, a teacher's mixed signals, or a boundary-crossing friend. Yet in many such cases, no…

Human-Computer Interaction · Computer Science 2026-04-28 Qiming Yuan , Linyi Han , Nam Ling , Cihan Ruan

Large language models (LLMs) often match or exceed clinician-level performance on medical benchmarks, yet very few are evaluated on real clinical data or examined beyond headline metrics. We present, to our knowledge, the first evaluation…

Large Language Models (LLMs) have attained human-level accuracy on medical question-answer (QA) benchmarks. However, their limitations in navigating open-ended clinical scenarios have recently been shown, raising concerns about the…

Computation and Language · Computer Science 2025-11-13 Jonathan Kim , Anna Podlasek , Kie Shidara , Feng Liu , Ahmed Alaa , Danilo Bernardo

Background: Recent advancements in large language models (LLMs) offer potential benefits in healthcare, particularly in processing extensive patient records. However, existing benchmarks do not fully assess LLMs' capability in handling…

Large language models (LLMs) are increasingly deployed in settings where the available context is incomplete or degraded. We argue that an LLM generating answers under incomplete context can be viewed as an implicit imputer, and evaluated…

Machine Learning · Statistics 2026-05-14 Stef van Buuren

Large Language Models (LLMs) have demonstrated remarkable adaptability, showcasing their capacity to excel in tasks for which they were not explicitly trained. However, despite their impressive natural language processing (NLP)…

Computation and Language · Computer Science 2023-09-08 Supun Manathunga , Isuru Hettigoda

Large Language Models (LLMs) are increasingly consulted for high-stakes life advice, yet they lack standard safeguards against providing confident but misguided responses. This creates risks of sycophancy and over-confidence. This paper…

Artificial Intelligence · Computer Science 2025-07-30 Joshua Adrian Cahyono , Saran Subramanian

Language models (LMs) are increasingly used to build agents that can act autonomously to achieve goals. During this automatic process, agents need to take a series of actions, some of which might lead to severe consequences if incorrect…

Computation and Language · Computer Science 2025-10-01 Cheng-Kuang Wu , Zhi Rui Tam , Chieh-Yen Lin , Yun-Nung Chen , Hung-yi Lee

Large language models (LLMs) are widely used in decision-making, but their reliability, especially in critical tasks like healthcare, is not well-established. Therefore, understanding how LLMs reason and make decisions is crucial for their…

Machine Learning · Computer Science 2025-02-25 Ze Yu Zhang , Arun Verma , Finale Doshi-Velez , Bryan Kian Hsiang Low

The deployment of Large Language Models in Medical Question Answering is severely hampered by ambiguous user queries, a significant safety risk that demonstrably reduces answer accuracy in high-stakes healthcare settings. In this paper, we…

Computation and Language · Computer Science 2026-01-27 Yaokun Liu , Yifan Liu , Phoebe Mbuvi , Zelin Li , Ruichen Yao , Gawon Lim , Dong Wang

Large Language Models (LLMs) are increasingly deployed in high-stakes domains such as clinical decision support and medical documentation. However, the robustness of these models against subtle linguistic variations, specifically…

Computation and Language · Computer Science 2026-05-19 Jen-tse Huang , Didi Zhou , Faith Kamau , Amy Oh , Anne R. Links , Mark Dredze , Mary Catherine Beach , Somnath Saha

One of the most widely used tasks for evaluating Large Language Models (LLMs) is Multiple-Choice Question Answering (MCQA). While open-ended question answering tasks are more challenging to evaluate, MCQA tasks are, in principle, easier to…

Computation and Language · Computer Science 2025-06-10 Francesco Maria Molfese , Luca Moroni , Luca Gioffré , Alessandro Scirè , Simone Conia , Roberto Navigli

The existing methods for evaluating the medical knowledge of Large Language Models (LLMs) are largely based on atemporal examination-style benchmarks, while in reality, medical knowledge is inherently dynamic and continuously evolves as new…

Machine Learning · Computer Science 2026-05-14 Zihan Guan , Qiao Jin , Guangzhi Xiong , Fangyuan Chen , Mengxuan Hu , Qingyu Chen , Yifan Peng , Zhiyong Lu , Anil Vullikanti

The growing awareness of safety concerns in large language models (LLMs) has sparked considerable interest in the evaluation of safety. This study investigates an under-explored issue about the evaluation of LLMs, namely the substantial…

Computation and Language · Computer Science 2024-04-02 Yixu Wang , Yan Teng , Kexin Huang , Chengqi Lyu , Songyang Zhang , Wenwei Zhang , Xingjun Ma , Yu-Gang Jiang , Yu Qiao , Yingchun Wang

As LLMs grow more powerful, their most profound achievement may be recognising when to say "I don't know". Existing studies on LLM self-knowledge have been largely constrained by human-defined notions of feasibility, often neglecting the…

Computation and Language · Computer Science 2025-09-16 Sahil Kale , Vijaykant Nadadur

Self-correction is an approach to improving responses from large language models (LLMs) by refining the responses using LLMs during inference. Prior work has proposed various self-correction frameworks using different sources of feedback,…

Computation and Language · Computer Science 2024-12-05 Ryo Kamoi , Yusen Zhang , Nan Zhang , Jiawei Han , Rui Zhang

Large language models (LLMs) have delivered significant breakthroughs across diverse domains but can still produce unreliable or misleading outputs, posing critical challenges for real-world applications. While many recent studies focus on…

Computation and Language · Computer Science 2025-09-08 Yang Nan , Pengfei He , Ravi Tandon , Han Xu