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Generative machine learning models can use data generated by scientific modeling to create large quantities of novel material structures. Here, we assess how one state-of-the-art generative model, the physics-guided crystal generation model…

De novo molecular generation is an essential task for science discovery. Recently, fragment-based deep generative models have attracted much research attention due to their flexibility in generating novel molecules based on existing…

Machine Learning · Computer Science 2023-02-28 Zijie Geng , Shufang Xie , Yingce Xia , Lijun Wu , Tao Qin , Jie Wang , Yongdong Zhang , Feng Wu , Tie-Yan Liu

The emergence of deep learning has brought the long-standing goal of comprehensively understanding and exploring crystalline materials closer to reality. Yet, universal exploration across all elements remains hindered by the combinatorial…

Materials Science · Physics 2025-11-18 Fengyu Xie , Ruoyu Wang , Taoyuze Lv , Yuxiang Gao , Hongyu Wu , Zhicheng Zhong

A wide range of synthesized crystalline inorganic materials exhibit compositional disorder, where multiple atomic species partially occupy the same crystallographic site. As a result, the physical and chemical properties of such materials…

Exploring the vast composition space of multi-component alloys presents a challenging task for both \textit{ab initio} (first principles) and experimental methods due to the time-consuming procedures involved. This ultimately impedes the…

Creative visual concept generation often draws inspiration from specific concepts in a reference image to produce relevant outcomes. However, existing methods are typically constrained to single-aspect concept generation or are easily…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Yangyang Li , Daqing Liu , Wu Liu , Allen He , Xinchen Liu , Yongdong Zhang , Guoqing Jin

Humans interpret complex visual stimuli using abstract concepts that facilitate decision-making tasks such as food selection and risk avoidance. Similarity judgment tasks are effective for exploring these concepts. However, methods for…

Neurons and Cognition · Quantitative Biology 2024-07-23 Chen Wei , Jiachen Zou , Dietmar Heinke , Quanying Liu

The constant demand for new functional materials calls for efficient strategies to accelerate the materials design and discovery. In addressing this challenge, machine learning generative models can offer promising opportunities since they…

Materials Science · Physics 2020-06-24 Sungwon Kim , Juhwan Noh , Geun Ho Gu , Alán Aspuru-Guzik , Yousung Jung

Co-crystallization is an accessible way to control physicochemical characteristics of organic crystals, which finds many biomedical applications. In this work, we present Generative Method for Co-crystal Design (GEMCODE), a novel pipeline…

The discovery of new materials is essential for enabling technological advancements. Computational approaches for predicting novel materials must effectively learn the manifold of stable crystal structures within an infinite design space.…

The design of functional materials with desired properties is essential in driving technological advances in areas like energy storage, catalysis, and carbon capture. Generative models provide a new paradigm for materials design by directly…

Machine learning has the potential to accelerate materials discovery by accurately predicting materials properties at a low computational cost. However, the model inputs remain a key stumbling block. Current methods typically use…

Computational Physics · Physics 2021-01-07 Rhys E. A. Goodall , Alpha A. Lee

We present a materials generation framework that couples a symmetry-conditioned variational autoencoder (CVAE) with a differentiable SO(3) power spectrum objective to steer candidates toward a specified local environment under the…

Materials Science · Physics 2026-01-13 Osman Goni Ridwan , Gilles Frapper , Hongfei Xue , Qiang Zhu

We propose Composition Sampling, a simple but effective method to generate diverse outputs for conditional generation of higher quality compared to previous stochastic decoding strategies. It builds on recently proposed plan-based neural…

Computation and Language · Computer Science 2022-03-30 Shashi Narayan , Gonçalo Simões , Yao Zhao , Joshua Maynez , Dipanjan Das , Michael Collins , Mirella Lapata

Recent large-scale generative models learned on big data are capable of synthesizing incredible images yet suffer from limited controllability. This work offers a new generation paradigm that allows flexible control of the output image,…

Computer Vision and Pattern Recognition · Computer Science 2023-02-23 Lianghua Huang , Di Chen , Yu Liu , Yujun Shen , Deli Zhao , Jingren Zhou

How do we measure genuine understanding in artificial cognitive systems? Current approaches face a measurement gap: probabilistic systems refine confidence gradually, practice-based systems compile knowledge through repeated execution, and…

Neurons and Cognition · Quantitative Biology 2026-05-05 Igor Balaz

Generative models have achieved impressive results in many domains including image and text generation. In the natural sciences, generative models have led to rapid progress in automated drug discovery. Many of the current methods focus on…

Machine Learning · Computer Science 2019-09-04 Jordan Hoffmann , Louis Maestrati , Yoshihide Sawada , Jian Tang , Jean Michel Sellier , Yoshua Bengio

Compositional generalization requires models to produce novel configurations from familiar parts. In diffusion models, prior compositional generation methods typically assume that the relevant concepts or conditioning signals are already…

Machine Learning · Computer Science 2026-05-11 Zekun Wang , Anant Gupta , Tianyi Zhu , Christopher J. MacLellan

Computational methods that automatically extract knowledge from data are critical for enabling data-driven materials science. A reliable identification of lattice symmetry is a crucial first step for materials characterization and…

Materials Science · Physics 2018-07-19 A. Ziletti , D. Kumar , M. Scheffler , L. M. Ghiringhelli

Due to the subtle balance of intermolecular interactions that govern structure-property relations, predicting the stability of crystal structures formed from molecular building blocks is a highly non-trivial scientific problem. A…

Chemical Physics · Physics 2022-12-26 Rose K. Cersonsky , Maria Pakhnova , Edgar A. Engel , Michele Ceriotti
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