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Drug resistance presents a major challenge in cancer therapy. Single cell profiling offers insights into cellular heterogeneity, yet the application of large-scale foundation models for predicting drug response in single cell data remains…

Artificial Intelligence · Computer Science 2025-05-12 Qing Wang , Yining Pan , Minghao Zhou , Zijia Tang , Yanfei Wang , Guangyu Wang , Qianqian Song

Can the rapid advances in code generation, function calling, and data analysis using large language models (LLMs) help automate the search and verification of hypotheses purely from a set of provided datasets? To evaluate this question, we…

There is an increasing need in our society to achieve faster advances in Science to tackle urgent problems, such as climate changes, environmental hazards, sustainable energy systems, pandemics, among others. In certain domains like…

Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from…

Machine Learning · Computer Science 2022-09-15 Hang Chen , Keqing Du , Xinyu Yang , Chenguang Li

Creating high-quality figures and visualizations for scientific papers is a time-consuming task that requires both deep domain knowledge and professional design skills. Despite over 2.5 million scientific papers published annually, the…

Artificial Intelligence · Computer Science 2026-01-09 Siyuan Huang , Yutong Gao , Juyang Bai , Yifan Zhou , Zi Yin , Xinxin Liu , Rama Chellappa , Chun Pong Lau , Sayan Nag , Cheng Peng , Shraman Pramanick

AI for Mathematics (AI4Math) has emerged as a distinct field that leverages machine learning to navigate mathematical landscapes historically intractable for early symbolic systems. While mid-20th-century symbolic approaches successfully…

History and Overview · Mathematics 2026-05-05 Haocheng Ju , Bin Dong

Main path analysis has long been used to trace knowledge trajectories in citation networks, yet it lacks solid theoretical foundations. To understand when and why this approach succeeds, we analyse directed acyclic graphs created from two…

Physics and Society · Physics 2025-12-16 H. C. W. Price , T. S. Evans

Large language models have achieved near-expert performance in structured reasoning domains like mathematics and programming, yet their ability to perform compositional multi-hop reasoning in specialized scientific fields remains limited.…

Artificial Intelligence · Computer Science 2026-03-09 Yuval Kansal , Niraj K. Jha

How do large language models solve spatial navigation tasks? We investigate this by training GPT-2 models on three spatial learning paradigms in grid environments: passive exploration (Foraging Model- predicting steps in random walks),…

Artificial Intelligence · Computer Science 2025-11-18 Caroline Baumgartner , Eleanor Spens , Neil Burgess , Petru Manescu

Large Language Models (LLMs) are catalyzing a paradigm shift in scientific discovery, evolving from task-specific automation tools into increasingly autonomous agents and fundamentally redefining research processes and human-AI…

Computation and Language · Computer Science 2025-09-18 Tianshi Zheng , Zheye Deng , Hong Ting Tsang , Weiqi Wang , Jiaxin Bai , Zihao Wang , Yangqiu Song

Most of the existing Large Language Model (LLM) benchmarks on scientific problem reasoning focus on problems grounded in high-school subjects and are confined to elementary algebraic operations. To systematically examine the reasoning…

Computation and Language · Computer Science 2024-07-01 Xiaoxuan Wang , Ziniu Hu , Pan Lu , Yanqiao Zhu , Jieyu Zhang , Satyen Subramaniam , Arjun R. Loomba , Shichang Zhang , Yizhou Sun , Wei Wang

Ensuring fairness in machine learning requires understanding how sensitive attributes like race or gender causally influence outcomes. Existing causal discovery (CD) methods often struggle to recover fairness-relevant pathways in the…

Machine Learning · Computer Science 2026-01-08 Khadija Zanna , Akane Sano

Humans can interpret geospatial information through natural language, while the geospatial cognition capabilities of Large Language Models (LLMs) remain underexplored. Prior research in this domain has been constrained by non-quantifiable…

OpenAI o1 represents a significant milestone in Artificial Inteiligence, which achieves expert-level performances on many challanging tasks that require strong reasoning ability.OpenAI has claimed that the main techinique behinds o1 is the…

Artificial Intelligence · Computer Science 2024-12-19 Zhiyuan Zeng , Qinyuan Cheng , Zhangyue Yin , Bo Wang , Shimin Li , Yunhua Zhou , Qipeng Guo , Xuanjing Huang , Xipeng Qiu

Understanding the qualitative patterns of research endeavor of scientific authors in terms of publication count and their impact (citation) is important in order to quantify success trajectories. Here, we examine the career profile of…

Digital Libraries · Computer Science 2016-02-08 Dinesh Pradhan , Tanmoy Chakraborty , Saswata Pandit , Subrata Nandi

Identifying and predicting the factors that contribute to the success of interdisciplinary research is crucial for advancing scientific discovery. However, there is a lack of methods to quantify the integration of new ideas and…

Instrumentation and Methods for Astrophysics · Physics 2024-06-18 Zechang Sun , Yuan-Sen Ting , Yaobo Liang , Nan Duan , Song Huang , Zheng Cai

Traditional fact checking by experts and analysts cannot keep pace with the volume of newly created information. It is important and necessary, therefore, to enhance our ability to computationally determine whether some statement of fact is…

Databases · Computer Science 2016-04-21 Baoxu Shi , Tim Weninger

Development in Artificial Intelligence (AI) has accelerated scientific discovery. Alongside recent AI-oriented Nobel prizes, these trends establish the role of AI tools in science. This advancement raises questions about the potential…

Computers and Society · Computer Science 2025-12-02 Qianyue Hao , Fengli Xu , Yong Li , James Evans

Existing reasoning datasets saturate and fail to test abstract, multi-step problems, especially pathfinding and complex rule constraint satisfaction. We introduce SPaRC (Spatial Pathfinding Reasoning Challenge), a dataset of 1,000 2D grid…

Artificial Intelligence · Computer Science 2025-09-22 Lars Benedikt Kaesberg , Jan Philip Wahle , Terry Ruas , Bela Gipp

While previous AI Scientist systems can generate novel findings, they often lack the focus to produce scientifically valuable contributions that address pressing human-defined challenges. We introduce DeepScientist, a system designed to…

Computation and Language · Computer Science 2025-10-01 Yixuan Weng , Minjun Zhu , Qiujie Xie , Qiyao Sun , Zhen Lin , Sifan Liu , Yue Zhang
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