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This experience report presents a model-driven approach to legacy system modernization that inserts an enriched, technology-agnostic intermediate model between the legacy codebase and the modern target platform, and reports on its…

Software Engineering · Computer Science 2026-02-05 Tobias Böhm , Jens Guan Su Tien , Mohini Nonnenmann , Tom Schoonbaert , Bart Carpels , Andreas Biesdorf

Duplicate records pose significant challenges in customer relationship management (CRM)and healthcare, often leading to inaccuracies in analytics, impaired user experiences, and compliance risks. Traditional deduplication methods rely…

Machine Learning · Computer Science 2026-03-27 Mohammed Omer Shakeel Ahmed

The rapid development of AI and LLMs has driven new methods of SDLC, in which a large portion of code, technical, and business documentation is generated automatically. However, since there is no single architectural framework that can…

Software Engineering · Computer Science 2026-04-02 Oleg Grynets , Vasyl Lyashkevych

Existing automated research systems operate as stateless, linear pipelines -- generating outputs without maintaining any persistent understanding of the research landscape they navigate. They process papers sequentially, propose ideas…

Artificial Intelligence · Computer Science 2026-03-27 Yunbo Long

Artificial Intelligence-assisted legacy modernization is essential in changing the stalwart mainframe systems of the past into flexible, scalable, and smart architecture. While mainframes are generally dependable, they can be difficult to…

Software Engineering · Computer Science 2025-12-08 Sunil Khemka , Arunava Majumdar

Artificial intelligence (AI) has the potential to transform healthcare by supporting more accurate diagnoses and personalized treatments. However, its adoption in practice remains constrained by fragmented data sources, strict privacy…

Software Engineering · Computer Science 2026-02-16 Mira Raheem , Amal Elgammal , Michael Papazoglou , Bernd Krämer , Neamat El-Tazi

Generative artificial intelligence (AI) is rapidly populating medical records with synthetic content, creating a feedback loop where future models are increasingly at risk of training on uncurated AI-generated data. However, the clinical…

Recent advances in artificial intelligence applied to biomedical text are opening exciting opportunities for improving pharmacovigilance activities currently burdened by the ever growing volumes of real world data. To fully realize these…

Information Retrieval · Computer Science 2022-01-04 Bruno Ohana , Jack Sullivan , Nicole Baker

Assurance for artificial intelligence (AI) systems remains fragmented across software supply-chain security, adversarial machine learning, and governance documentation. Existing transparency mechanisms - including Model Cards, Datasheets,…

Systematic literature review is essential for evidence-based medicine, requiring comprehensive analysis of clinical trial publications. However, the application of artificial intelligence (AI) models for medical literature mining has been…

The Artificial intelligence in critical sectors-healthcare, finance, and public safety-has made system integrity paramount for maintaining societal trust. Current verification methods for AI systems lack comprehensive lifecycle assurance,…

Cryptography and Security · Computer Science 2024-11-04 Mahesh Vaijainthymala Krishnamoorthy

Artificial intelligence (AI) holds great promise for supporting clinical trials, from patient recruitment and endpoint assessment to treatment response prediction. However, deploying AI without safeguards poses significant risks,…

Machine Learning · Computer Science 2025-10-09 Yao Chen , David Ohlssen , Aimee Readie , Gregory Ligozio , Ruvie Martin , Thibaud Coroller

Human-in-the-loop validation is essential in safety-critical clinical AI, yet the transition between initial model inference and expert correction is rarely analyzed as a structured signal. We introduce a diagnostic alignment framework in…

Artificial Intelligence · Computer Science 2026-02-27 Dimitrios P. Panagoulias , Evangelia-Aikaterini Tsichrintzi , Georgios Savvidis , Evridiki Tsoureli-Nikita

\textbf{Background:} Regulatory frameworks for AI in healthcare, including the EU AI Act and FDA guidance on AI/ML-based medical devices, require clinical decision support to demonstrate not only accuracy but auditability. Existing formal…

Artificial Intelligence · Computer Science 2026-04-24 Michael Bouzinier , Sergey Trifonov , Michael Chumack , Eugenia Lvova , Dmitry Etin

Electronic health record (EHR) systems present clinicians with vast repositories of clinical information, creating a significant cognitive burden where critical details are easily overlooked. While Large Language Models (LLMs) offer…

Computation and Language · Computer Science 2026-03-17 Samuel Thio , Matthew Lewis , Spiros Denaxas , Richard JB Dobson

Compound AI Systems (CAIS) are an emerging paradigm that integrates large language models (LLMs) with external components, including retrievers, agents, tools, and orchestrators, to overcome the limitations of standalone models in tasks…

Multiagent Systems · Computer Science 2026-05-11 Jiayi Chen , Junyi Ye , Guiling Wang

Background: As of 2026, Large Language Models (LLMs) demonstrate expert-level medical knowledge. However, deploying them as autonomous "Clinical Agents" remains limited. Current Electronic Medical Records (EMRs) and standards like FHIR are…

Artificial Intelligence · Computer Science 2026-05-26 Takahito Nakajima

The weaponization of LLMs for automated malware generation poses an existential threat to conventional detection paradigms. AI-generated malware exhibits polymorphic, metamorphic, and context-aware evasion capabilities that render…

Cryptography and Security · Computer Science 2026-03-11 George Edwards , Mahdi Eslamimehr

Unstructured text from legal, medical, and administrative sources offers a rich but underutilized resource for research in public health and the social sciences. However, large-scale analysis is hampered by two key challenges: the presence…

Computation and Language · Computer Science 2025-07-16 Anders Ledberg , Anna Thalén

Most existing approaches to AI in pharmacy collapse three epistemologically distinct operations into a single technical layer: document preservation, semantic interpretation, and contextual presentation. This conflation is a root cause of…

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