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Medical imaging is essential in modern radiotherapy, supporting diagnosis, treatment planning, and monitoring. Synthetic imaging, particularly synthetic computed tomography (sCT), is gaining traction in radiotherapy. The SynthRAD2025…

Purpose: Medical imaging has become increasingly important in diagnosing and treating oncological patients, particularly in radiotherapy. Recent advances in synthetic computed tomography (sCT) generation have increased interest in public…

Image synthesis is used to generate synthetic CTs (sCTs) from on-treatment cone-beam CTs (CBCTs) with a view to improving image quality and enabling accurate dose computation to facilitate a CBCT-based adaptive radiotherapy workflow. As…

Image and Video Processing · Electrical Eng. & Systems 2023-12-05 Chelsea A. H. Sargeant , Edward G. A. Henderson , Dónal M. McSweeney , Aaron G. Rankin , Denis Page

Cone beam computed tomography (CBCT) images can be used for dose calculation in adaptive radiation therapy (ART). The main challenges are the large artefacts and inaccurate Hounsfield unit (HU) values. Currently, deformed planning CT images…

Medical Physics · Physics 2019-09-04 Xiao Liang , Liyuan Chen , Dan Nguyen , Zhiguo Zhou , Xuejun Gu , Ming Yang , Jing Wang , Steve Jiang

The generation of synthetic CT (sCT) images from cone-beam CT (CBCT) data using deep learning methodologies represents a significant advancement in radiation oncology. This systematic review, following PRISMA guidelines and using the PICO…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Alzahra Altalib , Scott McGregor , Chunhui Li , Alessandro Perelli

Purpose: This study assesses the effectiveness of Deep Learning (DL) for creating synthetic CT (sCT) images in MR-guided adaptive radiation therapy (MRgART). Methods: A Cycle-GAN model was trained with MRI and CT scan slices from MR-LINAC…

Accurate dose calculations in proton therapy rely on high-quality CT images. While planning CTs (pCTs) serve as a reference for dosimetric planning, Cone Beam CT (CBCT) is used throughout Adaptive Radiotherapy (ART) to generate sCTs for…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 David Vallmanya Poch , Yorick Estievenart , Elnura Zhalieva , Sukanya Patra , Mohammad Yaqub , Souhaib Ben Taieb

Background: Cone-beam computed tomography (CBCT) scans, performed fractionally (e.g., daily or weekly), are widely utilized for patient alignment in the image-guided radiotherapy (IGRT) process, thereby making it a potential imaging…

Cone Beam CT (CBCT) plays a crucial role in Adaptive Radiation Therapy (ART) by accurately providing radiation treatment when organ anatomy changes occur. However, CBCT images suffer from scatter noise and artifacts, making relying solely…

Image and Video Processing · Electrical Eng. & Systems 2023-08-08 Linjie Fu , Xia Li , Xiuding Cai , Dong Miao , Yu Yao , Yali Shen

Purpose: Organ-at-risk (OAR) delineation is a key step for cone-beam CT (CBCT) based adaptive radiotherapy planning that can be a time-consuming, labor-intensive, and subject-to-variability process. We aim to develop a fully automated…

Synthetic CT image generation from MRI scan is necessary to create radiotherapy plans without the need of co-registered MRI and CT scans. The chosen baseline adversarial model with cycle consistency permits unpaired image-to-image…

Image and Video Processing · Electrical Eng. & Systems 2023-08-16 Denis Prokopenko , Joël Valentin Stadelmann , Heinrich Schulz , Steffen Renisch , Dmitry V. Dylov

Cone-Beam Computed Tomography (CBCT) is widely used for real-time intraoperative imaging due to its low radiation dose and high acquisition speed. However, despite its high resolution, CBCT suffers from significant artifacts and thereby…

Image and Video Processing · Electrical Eng. & Systems 2025-06-11 Maximilian Tschuchnig , Lukas Lamminger , Philipp Steininger , Michael Gadermayr

Cone-Beam Computed Tomography (CBCT) is widely used for intraoperative imaging due to its rapid acquisition and low radiation dose. However, CBCT images typically suffer from artifacts and lower visual quality compared to conventional…

Image and Video Processing · Electrical Eng. & Systems 2025-07-09 Maximilian Tschuchnig , Lukas Lamminger , Philipp Steininger , Michael Gadermayr

Background: In MR-guided proton therapy planning, aligning MR and CT images is key for MR-based CT synthesis, especially in mobile regions like the head-and-neck. Misalignments here can lead to less accurate synthetic CT (sCT) images,…

Generating synthetic CT (sCT) from MRI or CBCT plays a crucial role in enabling MRI-only and CBCT-based adaptive radiotherapy, improving treatment precision while reducing patient radiation exposure. To address this task, we adopt a fully…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Arnela Hadzic , Simon Johannes Joham , Martin Urschler

In radiation therapy (RT), the reliance on pre-treatment computed tomography (CT) images encounter challenges due to anatomical changes, necessitating adaptive planning. Daily cone-beam CT (CBCT) imaging, pivotal for therapy adjustment,…

Computer Vision and Pattern Recognition · Computer Science 2024-09-20 Joonil Hwang , Sangjoon Park , NaHyeon Park , Seungryong Cho , Jin Sung Kim

Purpose: This study assessed the dosimetric accuracy of synthetic CT images generated from magnetic resonance imaging (MRI) data for focal brain radiation therapy, using a deep learning approach. Material and Methods: We conducted a study…

Magnetic resonance imaging (MRI)-based synthetic computed tomography (sCT) simplifies radiation therapy treatment planning by eliminating the need for CT simulation and error-prone image registration, ultimately reducing patient radiation…

Image and Video Processing · Electrical Eng. & Systems 2023-06-01 Shaoyan Pan , Elham Abouei , Jacob Wynne , Tonghe Wang , Richard L. J. Qiu , Yuheng Li , Chih-Wei Chang , Junbo Peng , Justin Roper , Pretesh Patel , David S. Yu , Hui Mao , Xiaofeng Yang

Purpose: Accurate dose calculation is essential in radiotherapy for precise tumor irradiation while sparing healthy tissue. With the growing adoption of MRI-guided and real-time adaptive radiotherapy, fast and accurate dose calculation on…

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