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Molecular property prediction (MPP) is a cornerstone of drug discovery and materials science, yet conventional deep learning approaches depend on large labeled datasets that are often unavailable. Few-shot Molecular property prediction…

Machine Learning · Computer Science 2025-10-27 Xiangyang Xu , Hongyang Gao

Molecular property prediction (MPP) is integral to drug discovery and material science, but often faces the challenge of data scarcity in real-world scenarios. Addressing this, few-shot molecular property prediction (FSMPP) has been…

Machine Learning · Computer Science 2024-11-05 Liang Wang , Qiang Liu , Shaozhen Liu , Xin Sun , Shu Wu , Liang Wang

Recently, few-shot molecular property prediction (FSMPP) has garnered increasing attention. Despite impressive breakthroughs achieved by existing methods, they often overlook the inherent many-to-many relationships between molecules and…

Quantitative Methods · Quantitative Biology 2024-05-27 Zeyu Wang , Tianyi Jiang , Yao Lu , Xiaoze Bao , Shanqing Yu , Bin Wei , Qi Xuan

Molecular property prediction is becoming one of the major applications of graph learning in Web-based services, e.g., online protein structure prediction and drug discovery. A key challenge arises in few-shot scenarios, where only a few…

Machine Learning · Computer Science 2026-01-19 Van Thuy Hoang , O-Joun Lee

AI-assisted molecular property prediction has become a promising technique in early-stage drug discovery and materials design in recent years. However, due to high-cost and complex wet-lab experiments, real-world molecules usually…

Computational Engineering, Finance, and Science · Computer Science 2025-10-13 Zeyu Wang , Tianyi Jiang , Huanchang Ma , Yao Lu , Xiaoze Bao , Shanqing Yu , Qi Xuan , Shirui Pan , Xin Zheng

In-context learning has become an important approach for few-shot learning in Large Language Models because of its ability to rapidly adapt to new tasks without fine-tuning model parameters. However, it is restricted to applications in…

Machine Learning · Computer Science 2023-10-16 Christopher Fifty , Jure Leskovec , Sebastian Thrun

Molecular property prediction (MPP) is a fundamental and crucial task in drug discovery. However, prior methods are limited by the requirement for a large number of labeled molecules and their restricted ability to generalize for unseen and…

Quantitative Methods · Quantitative Biology 2024-10-21 Yuyan Liu , Sirui Ding , Sheng Zhou , Wenqi Fan , Qiaoyu Tan

Molecular property is usually observed with a limited number of samples, and researchers have considered property prediction as a few-shot problem. One important fact that has been ignored by prior works is that each molecule can be…

Machine Learning · Computer Science 2023-06-30 Xiang Zhuang , Qiang Zhang , Bin Wu , Keyan Ding , Yin Fang , Huajun Chen

The recent success of graph neural networks has significantly boosted molecular property prediction, advancing activities such as drug discovery. The existing deep neural network methods usually require large training dataset for each…

Machine Learning · Computer Science 2021-02-17 Zhichun Guo , Chuxu Zhang , Wenhao Yu , John Herr , Olaf Wiest , Meng Jiang , Nitesh V. Chawla

Few-shot Learning (FSL) aims to classify new concepts from a small number of examples. While there have been an increasing amount of work on few-shot object classification in the last few years, most current approaches are limited to images…

Computer Vision and Pattern Recognition · Computer Science 2021-01-05 Mathieu Pagé Fortin , Brahim Chaib-draa

Few-shot learning is a promising approach to molecular property prediction as supervised data is often very limited. However, many important molecular properties depend on complex molecular characteristics -- such as the various 3D…

Machine Learning · Computer Science 2023-10-10 Christopher Fifty , Joseph M. Paggi , Ehsan Amid , Jure Leskovec , Ron Dror

Few-shot semantic segmentation is the task of learning to locate each pixel of the novel class in the query image with only a few annotated support images. The current correlation-based methods construct pair-wise feature correlations to…

Computer Vision and Pattern Recognition · Computer Science 2023-01-20 Huafeng Liu , Pai Peng , Tao Chen , Qiong Wang , Yazhou Yao , Xian-Sheng Hua

Predicting the activities of compounds against protein-based or phenotypic assays using only a few known compounds and their activities is a common task in target-free drug discovery. Existing few-shot learning approaches are limited to…

Machine Learning · Computer Science 2023-11-29 Peter Eckmann , Jake Anderson , Michael K. Gilson , Rose Yu

Recent years have witnessed increasing interest in few-shot knowledge graph completion (FKGC), which aims to infer unseen query triples for a few-shot relation using a few reference triples about the relation. The primary focus of existing…

Computation and Language · Computer Science 2022-09-28 Yuling Li , Kui Yu , Yuhong Zhang , Xindong Wu

Few-shot semantic segmentation (FSS) aims to achieve novel objects segmentation with only a few annotated samples and has made great progress recently. Most of the existing FSS models focus on the feature matching between support and query…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Jie Liu , Yanqi Bao , Wenzhe Yin , Haochen Wang , Yang Gao , Jan-Jakob Sonke , Efstratios Gavves

A central task in computational drug discovery is to construct models from known active molecules to find further promising molecules for subsequent screening. However, typically only very few active molecules are known. Therefore, few-shot…

Few-shot segmentation is a task to segment objects or regions of novel classes within an image given only a few annotated examples. In the generalized setting, the task extends to segment both the base and the novel classes. The main…

Computer Vision and Pattern Recognition · Computer Science 2024-04-17 Steve Andreas Immanuel , Hagai Raja Sinulingga

Molecular property prediction (MPP) is a fundamental but challenging task in the computer-aided drug discovery process. More and more recent works employ different graph-based models for MPP, which have made considerable progress in…

Machine Learning · Computer Science 2023-12-29 Bangyi Zhao , Weixia Xu , Jihong Guan , Shuigeng Zhou

Few-shot Knowledge Graph Completion (FKGC) infers missing triples from limited support samples, tackling long-tail distribution challenges. Existing methods, however, struggle to capture complex relational patterns and mitigate data…

Computation and Language · Computer Science 2026-01-22 Zilong Wang , Qingtian Zeng , Hua Duan , Cheng Cheng , Minghao Zou , Ziyang Wang

Few-shot relational learning on knowledge graph (KGs) aims to perform reasoning over relations with only a few training examples. While current methods have focused primarily on leveraging specific relational information, rich semantics…

Artificial Intelligence · Computer Science 2025-11-06 Han Wu , Jie Yin
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