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Estimating an individual's counterfactual outcomes under interventions is a challenging task for traditional causal inference and supervised learning approaches when the outcome is high-dimensional (e.g. gene expressions, facial images) and…

Machine Learning · Computer Science 2025-03-19 Yulun Wu , Louie McConnell , Claudia Iriondo

Tubular tree structures such as blood vessels and lung airways are central to many clinical tasks, including diagnosis, treatment planning, and surgical navigation. Accurate centerline extraction with correct topology is essential, as…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Roman Naeem , David Hagerman , Jennifer Alvén , Fredrik Kahl

Enzyme-reaction retrieval is a fundamental problem in computational biology, underpinning enzyme characterization, reaction mechanism elucidation, and the rational design of metabolic pathways and biocatalysts. As a bidirectional task, it…

Artificial Intelligence · Computer Science 2026-05-26 Yuhang Zhang , Keyan Ding , Peilin Chen , Han Liu , Can Lin , Ruixi Chen , Shiqi Wang , Qi Song

Reducing the requirement for densely annotated masks in medical image segmentation is important due to cost constraints. In this paper, we consider the problem of inferring pixel-level predictions of brain lesions by only using image-level…

Computer Vision and Pattern Recognition · Computer Science 2022-07-26 Pedro Sanchez , Antanas Kascenas , Xiao Liu , Alison Q. O'Neil , Sotirios A. Tsaftaris

Continuous electroencephalography (EEG) is routinely used in neurocritical care to monitor seizures and other harmful brain activity, including rhythmic and periodic patterns that are clinically significant. Although deep learning methods…

Human-Computer Interaction · Computer Science 2026-01-05 Argha Kamal Samanta , Deepak Mewada , Monalisa Sarma , Debasis Samanta

Boundary representation (B-rep) of geometric models is a fundamental format in Computer-Aided Design (CAD). However, automatically generating valid and high-quality B-rep models remains challenging due to the complex interdependence between…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Jing Li , Yihang Fu , Falai Chen

For decades, a variety of predictive approaches have been proposed and evaluated in terms of their prediction capability for Alzheimer's Disease (AD) and its precursor - mild cognitive impairment (MCI). Most of them focused on prediction or…

Neurons and Cognition · Quantitative Biology 2022-12-20 Lu Zhang , Li Wang , Tianming Liu , Dajiang Zhu

We propose a topological framework to study the evolution of Alzheimer's disease, the most common neurodegenerative disease. The modeling of this disease starts with the representation of the brain connectivity as a graph and the seeding of…

Neurons and Cognition · Quantitative Biology 2023-09-20 Christian Goodbrake , David Beers , Travis B. Thompson , Heather A. Harrington , Alain Goriely

Objective: To analyze the frequency and co-occurrence of dermoscopic patterns in BCC lesions and their relationship with histopathologic subtypes, using statistical analysis and Information Theory tools such as entropy, conditional entropy,…

Quantitative Methods · Quantitative Biology 2025-04-08 Iván Matas , Begoña Acha , Francisca Silva-Clavería , Amalia Serrano , Tomás Toledo-Pastrana , Carmen Serrano

Counterfactual explanation is a form of interpretable machine learning that generates perturbations on a sample to achieve the desired outcome. The generated samples can act as instructions to guide end users on how to observe the desired…

Machine Learning · Computer Science 2023-03-28 Tri Dung Duong , Qian Li , Guandong Xu

Retinal artery/vein (A/V) classification is a critical technique for diagnosing diabetes and cardiovascular diseases. Although deep learning based methods achieve impressive results in A/V classification, their performances usually degrade…

Computer Vision and Pattern Recognition · Computer Science 2021-06-21 Chenxin Li , Yunlong Zhang , Zhehan Liang , Wenao Ma , Yue Huang , Xinghao Ding

Retinal artery/vein (A/V) classification lays the foundation for the quantitative analysis of retinal vessels, which is associated with potential risks of various cardiovascular and cerebral diseases. The topological connection…

Image and Video Processing · Electrical Eng. & Systems 2020-07-30 Wenting Chen , Shuang Yu , Junde Wu , Kai Ma , Cheng Bian , Chunyan Chu , Linlin Shen , Yefeng Zheng

We present ENTED, a new framework for blind face restoration that aims to restore high-quality and realistic portrait images. Our method involves repairing a single degraded input image using a high-quality reference image. We utilize a…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Yuen-Fui Lau , Tianjia Zhang , Zhefan Rao , Qifeng Chen

Automated segmentation of retinal blood vessels in label-free fundus images entails a pivotal role in computed aided diagnosis of ophthalmic pathologies, viz., diabetic retinopathy, hypertensive disorders and cardiovascular diseases. The…

Computer Vision and Pattern Recognition · Computer Science 2016-11-17 Avisek Lahiri , Abhijit Guha Roy , Debdoot Sheet , Prabir Kumar Biswas

Background: Predicting the efficacy of combination therapies is a critical challenge in clinical decision-making, particularly for diseases requiring multi-drug regimens. Traditional evidence synthesis methods, such as component network…

Quantitative Methods · Quantitative Biology 2025-03-31 Dipayan Sengupta , Saumya Panda

The rapid progress of generative models has intensified the need for reliable and robust detection under real-world conditions. However, existing detectors often overfit to generator-specific artifacts and remain highly sensitive to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-25 Ruiqi Liu , Yi Han , Zhengbo Zhang , Liwei Yao , Zhiyuan Yan , Jialiang Shen , ZhiJin Chen , Boyi Sun , Lubin Weng , Jing Dong , Yan Wang , Shu Wu

Retinal vascular segmentation, a widely researched topic in biomedical image processing, aims to reduce the workload of ophthalmologists in treating and detecting retinal disorders. Segmenting retinal vessels presents unique challenges;…

Image and Video Processing · Electrical Eng. & Systems 2025-01-06 Melaku N. Getahun , Oleg Y. Rogov , Dmitry V. Dylov , Andrey Somov , Ahmed Bouridane , Rifat Hamoudi

Counterfactual estimation over time is important in various applications, such as personalized medicine. However, time-dependent confounding bias in observational data still poses a significant challenge in achieving accurate and efficient…

Machine Learning · Computer Science 2026-03-13 Nghia D. Nguyen , Pablo Robles-Granda , Lav R. Varshney

Anomaly detection in retinal image refers to the identification of abnormality caused by various retinal diseases/lesions, by only leveraging normal images in training phase. Normal images from healthy subjects often have regular structures…

Image and Video Processing · Electrical Eng. & Systems 2020-08-11 Kang Zhou , Yuting Xiao , Jianlong Yang , Jun Cheng , Wen Liu , Weixin Luo , Zaiwang Gu , Jiang Liu , Shenghua Gao

We present a fully automatic, graph-based technique for extracting the retinal vascular topology -- that is, how different vessels are connected to each other -- given a single color fundus image. Determining this connectivity is very…

Image and Video Processing · Electrical Eng. & Systems 2022-08-09 Aashis Khanal , Saeid Motevali , Rolando Estrada