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The cerebrovascular tree is a complex anatomical structure that plays a crucial role in the brain irrigation. A precise identification of the bifurcations in the vascular network is essential for understanding various cerebral pathologies.…

Image and Video Processing · Electrical Eng. & Systems 2023-08-25 Ibtissam Essadik , Anass Nouri , Raja Touahni , Florent Autrusseau

Topological and geometrical analysis of retinal blood vessel is a cost-effective way for early detection of many common diseases. Meanwhile, automated vessel segmentation and vascular tree analysis are still lacking in terms of…

Image and Video Processing · Electrical Eng. & Systems 2021-11-24 Xingzheng Lyu , Li Cheng , Sanyuan Zhang

Counterfactual explanations (CEs) aim to enhance the interpretability of machine learning models by illustrating how alterations in input features would affect the resulting predictions. Common CE approaches require an additional model and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-02 Matan Atad , David Schinz , Hendrik Moeller , Robert Graf , Benedikt Wiestler , Daniel Rueckert , Nassir Navab , Jan S. Kirschke , Matthias Keicher

Current continuous generative models (e.g., Diffusion Models, Flow Matching) implicitly assume that locally consistent causal mechanisms naturally yield globally coherent counterfactuals. In this paper, we prove that this assumption fails…

Machine Learning · Computer Science 2026-03-19 Rui Wu , Hong Xie , Yongjun Li

Structural changes in retinal blood vessels are critical biomarkers for the onset and progression of glaucoma and other ocular diseases. However, current vessel segmentation approaches largely rely on supervised learning and extensive…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Cheng Huang , Weizheng Xie , Fan Gao , Yutong Liu , Ruoling Wu , Zeyu Han , Jingxi Qiu , Xiangxiang Wang , Zhenglin Yang , Hao Wang , Yongbin Yu

Diseases such as diabetic retinopathy and age-related macular degeneration pose a significant risk to vision, highlighting the importance of precise segmentation of retinal vessels for the tracking and diagnosis of progression. However,…

Image and Video Processing · Electrical Eng. & Systems 2023-09-08 Tariq M. Khan , Muhammad Arsalan , Shahzaib Iqbal , Imran Razzak , Erik Meijering

We introduce a novel framework for learning vector representations of tree-structured geometric data focusing on 3D vascular networks. Our approach employs two sequentially trained Transformer-based autoencoders. In the first stage, the…

Image and Video Processing · Electrical Eng. & Systems 2025-06-16 James Batten , Michiel Schaap , Matthew Sinclair , Ying Bai , Ben Glocker

As AI models grow more complex, explainability is essential for building trust, yet concept-based counterfactual methods still face a trade-off between expressivity and efficiency. Representing underlying concepts as atomic sets is fast but…

Artificial Intelligence · Computer Science 2026-05-22 Angeliki Dimitriou , Nikolaos Chaidos , Maria Lymperaiou , Giorgos Filandrianos , Giorgos Stamou

Precise segmentation of retinal arteries and veins carries the diagnosis of systemic cardiovascular conditions. However, standard convolutional architectures often yield topologically disjointed segmentations, characterized by gaps and…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Iftekhar Ahmed , Shakib Absar , Aftar Ahmad Sami , Shadman Sakib , Debojyoti Biswas , Seraj Al Mahmud Mostafa

Blood vessel segmentation is crucial for many diagnostic and research applications. In recent years, CNN-based models have leaded to breakthroughs in the task of segmentation, however, such methods usually lose high-frequency information…

Image and Video Processing · Electrical Eng. & Systems 2021-04-09 Mo Zhang , Fei Yu , Jie Zhao , Li Zhang , Quanzheng Li

We introduce GENomic Encoding REpresentation with Language Model (GENEREL), a framework designed to bridge genetic and biomedical knowledge bases. What sets GENEREL apart is its ability to fine-tune language models to infuse biological…

Machine Learning · Computer Science 2024-10-15 Hongyi Yuan , Suqi Liu , Kelly Cho , Katherine Liao , Alexandre Pereira , Tianxi Cai

Purpose: To demonstrate that retinal microvasculature per se is a reliable biomarker for Diabetic Retinopathy (DR) and, by extension, cardiovascular diseases. Methods: Deep Learning Convolutional Neural Networks (CNN) applied to color…

Image and Video Processing · Electrical Eng. & Systems 2021-07-29 Anusua Trivedi , Jocelyn Desbiens , Ron Gross , Sunil Gupta , Rahul Dodhia , Juan Lavista Ferres

Counterfactual explanations offer an intuitive way to interpret graph neural networks (GNNs) by identifying minimal changes that alter a model's prediction, thereby answering "what must differ for a different outcome?". In this work, we…

Machine Learning · Computer Science 2026-02-09 Yu Zhang , Sean Bin Yang , Arijit Khan , Cuneyt Gurcan Akcora

Systemic diseases such as diabetes, hypertension, atherosclerosis are among the leading causes of annual human mortality rate. It is suggested that retinal and conjunctival vascular tortuosity is a potential biomarker for such systemic…

Image and Video Processing · Electrical Eng. & Systems 2021-01-05 Ashwin De Silva , Malsha V. Perera , Navodini Wijethilake , Saroj Jayasinghe , Nuwan D. Nanayakkara , Anjula De Silva

Retinal blood vessels are considered to be the reliable diagnostic biomarkers of ophthalmologic and diabetic retinopathy. Monitoring and diagnosis totally depends on expert analysis of both thin and thick retinal vessels which has recently…

Image and Video Processing · Electrical Eng. & Systems 2019-12-24 Waseem Abbas , Muhammad Haroon Shakeel , Numan Khurshid , Murtaza Taj

Retinal images provide early signs of diabetic retinopathy, glaucoma, and hypertension. These signs can be investigated based on microaneurysms or smaller vessels. The diagnostic biomarkers are the change of vessel widths and angles…

Computer Vision and Pattern Recognition · Computer Science 2016-05-24 Marta Favali , Samaneh Abbasi-Sureshjani , Bart ter Haar Romeny , Alessandro Sarti

Brain connectivity analysis based on magnetic resonance imaging is crucial for understanding neurological mechanisms. However, edge-based connectivity inference faces significant challenges, particularly the curse of dimensionality when…

Methodology · Statistics 2025-12-23 Zijing Li , Chenhao Zeng , Shufei Ge

Scientific diagrams convey explicit structural information, yet modern text-to-image models often produce visually plausible but structurally incorrect results. Existing benchmarks either rely on image-centric or subjective metrics…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Tong Zhang , Honglin Lin , Zhou Liu , Chong Chen , Wentao Zhang

Variational autoencoders (VAEs) and other generative methods have garnered growing interest not just for their generative properties but also for the ability to dis-entangle a low-dimensional latent variable space. However, few existing…

Machine Learning · Computer Science 2023-02-14 Sunay Bhat , Jeffrey Jiang , Omead Pooladzandi , Gregory Pottie

Anatomical trees are critical for clinical diagnosis and treatment planning, yet their complex and diverse geometry make accurate representation a significant challenge. Motivated by the latest advances in large language models, we…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Paula Feldman , Martin Sinnona , Claudio Delrieux , Viviana Siless , Emmanuel Iarussi
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