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As the global population grows and climate change intensifies, sustainable food production is critical. Marine aquaculture offers a viable solution, providing a sustainable protein source. However, the industry's expansion requires novel…

Machine Learning · Computer Science 2024-06-11 Eirini Katsidoniotaki , Biao Su , Eleni Kelasidi , Themistoklis P. Sapsis

The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be…

Quantitative Methods · Quantitative Biology 2024-03-22 Lucas Böttcher , Luis L. Fonseca , Reinhard C. Laubenbacher

The human insulin-glucose metabolism is a time-varying process, which is partly caused by the changing insulin sensitivity of the body. This insulin sensitivity follows a circadian rhythm and its effects should be anticipated by any…

Systems and Control · Electrical Eng. & Systems 2021-01-29 Lukas Ortmann , Dawei Shi , Eyal Dassau , Francis J. Doyle , Berno J. E. Misgeld , Steffen Leonhardt

Foundation models are trained on a large amount of data to learn generic patterns. Consequently, these models can be used and fine-tuned for various purposes. Naturally, studying such models' use in the context of digital twins for…

Software Engineering · Computer Science 2025-07-03 Shaukat Ali , Paolo Arcaini , Aitor Arrieta

Stochastic simulation is widely used to study complex systems composed of various interconnected subprocesses, such as input processes, routing and control logic, optimization routines, and data-driven decision modules. In practice, these…

Computation · Statistics 2026-02-19 Mohammadmahdi Ghasemloo , David J. Eckman , Yaxian Li

Digital twins, integral to cloud platforms, bridge physical and virtual worlds, fostering collaboration among stakeholders in manufacturing and processing. However, the cloud platforms face challenges like service outages, vulnerabilities,…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-05 Deepika Saxena , Ashutosh Kumar Singh

The adoption of Digital Twin technologies is rapidly expanding in diverse industrial, economic, and societal domains. Over the past decade, a multitude of studies, surveys, and investigations have been conducted, examining the nature,…

Software Engineering · Computer Science 2026-03-09 Philipp Zech , Yanis Mair , Michael Vierhauser , Pablo Oliveira Antonino , Frank Schnicke , Tony Clark

AI procedures joined with wearable gadgets can convey exact transient blood glucose level forecast models. Also, such models can learn customized glucose-insulin elements dependent on the sensor information gathered by observing a few parts…

Machine Learning · Computer Science 2021-01-22 Ignacio Rodriguez

Precise and timely forecasting of blood glucose levels is essential for effective diabetes management. While extensive research has been conducted on Type 1 diabetes mellitus, Type 2 diabetes mellitus (T2DM) presents unique challenges due…

Computational Engineering, Finance, and Science · Computer Science 2024-09-12 Yuyang Sun , Panagiotis Kosmas

Neurodevelopmental disorders (NDDs) cover a variety of conditions, including autism spectrum disorder, attention-deficit/hyperactivity disorder, and epilepsy, which impair the central and peripheral nervous systems. Their high comorbidity…

Neurons and Cognition · Quantitative Biology 2025-01-16 Kuanren Qian , Genesis Omana Suarez , Toshihiko Nambara , Takahisa Kanekiyo , Yongjie Jessica Zhang

The concept of Digital Twin (DT) is increasingly applied to systems on different levels of abstraction across domains, to support monitoring, analysis, diagnosis, decision making and automated control. Whilst the interest in applying DT is…

Software Engineering · Computer Science 2024-06-05 Ran Wei , Ruizhe Yang , Shijun Liu , Chongsheng Fan , Rong Zhou , Zekun Wu , Haochi Wang , Yifan Cai , Zhe Jiang

With the accelerating availability of multimodal surgical data and real-time computation, Surgical Digital Twins (SDTs) have emerged as virtual counterparts that mirror, predict, and inform decisions across pre-, intra-, and postoperative…

Brain digital twins aim to provide faithful, individualized computational representations of brains as dynamical systems, enabling mechanistic understanding and supporting prediction of clinical interventions. Yet current approaches remain…

Computational Engineering, Finance, and Science · Computer Science 2026-04-16 Alexandre Muzy

Deep learning models have achieved strong performance in medical image analysis, but their internal decision processes remain difficult to interpret. Concept Bottleneck Models (CBMs) partially address this limitation by structuring…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Getamesay Dagnaw , Xuefei Yin , Muhammad Hassan Maqsood , Yanming Zhu , Alan Wee-Chung Liew

Objective: Modern medicine needs to shift from a wait and react, curative discipline to a preventative, interdisciplinary science aiming at providing personalised, systemic and precise treatment plans to patients. The aim of this work is to…

Machine Learning · Statistics 2020-09-18 Pietro Barbiero , Ramon Viñas Torné , Pietro Lió

Digital twins offer a promising solution to the lack of sufficient labeled data in deep learning-based fault diagnosis by generating simulated data for model training. However, discrepancies between simulation and real-world systems can…

Machine Learning · Computer Science 2025-09-05 Zhenling Chen , Haiwei Fu , Zhiguo Zeng

Synthetic clinical data are increasingly important for advancing AI in healthcare, given strict privacy constraints on real-world EHRs, limited availability of annotated rare-condition data, and systemic biases in observational datasets.…

Machine Learning · Computer Science 2025-09-16 Rumeng Li , Xun Wang , Hong Yu

We live in a world of exploding complexity driven by technical evolution as well as highly volatile socio-economic environments. Managing complexity is a key issue in everyday decision making such as providing safe, sustainable, and…

Computers and Society · Computer Science 2023-11-28 Dirk Hartmann

Diabetes is currently one of the most common, dangerous, and costly diseases in the world that is caused by an increase in blood sugar or a decrease in insulin in the body. Diabetes can have detrimental effects on people's health if…

Machine Learning · Computer Science 2021-03-16 Jafar Abdollahi , Babak Nouri-Moghaddam

Cardiac arrest is one of the biggest global health problems, and early identification and management are key to enhancing the patient's prognosis. In this paper, we propose a novel framework that combines an EfficientNet-based deep learning…

Machine Learning · Computer Science 2025-09-10 Qasim Zia , Avais Jan , Zafar Iqbal , Muhammad Mumtaz Ali , Mukarram Ali , Murray Patterson
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